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Preparation of bitteridone and its application in personal care products

A kind of technology of sophorone and weight, applied in the field of preparation of high-purity sophorone, can solve problems such as difficult to control quality, unsuitable for large-scale production, complicated operation and the like

Active Publication Date: 2020-07-28
YUN BAI YAO ZHENG WU TECH SHANGHAI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above three patent applications all use column chromatography method, which is not only not suitable for large-scale production, but also complicated to operate and difficult to control quality

Method used

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  • Preparation of bitteridone and its application in personal care products
  • Preparation of bitteridone and its application in personal care products
  • Preparation of bitteridone and its application in personal care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: the preparation of bitter soybean ketone

[0048] This embodiment illustrates the specific operation steps of the present invention for the preparation of Kududanone.

[0049] The origin of the bitter bean rhizome medicinal material is Ningxia Hui Autonomous Region.

[0050] 500 grams of rhizomes of Sophora sophora are first crushed into fragments or powders with an average diameter of 0.1-5 mm, and soaked in 5 liters of 95% ethanol at room temperature for 3 days. This extraction process was repeated 2 times. The combined extracts were filtered and concentrated to remove solvent. Obtained 45 grams of brown-black oil. The oil and 200 grams (about 4 times the weight) of 200-300 mesh silica gel were mixed and stirred to form a solid. The solid was placed on a Soxhlet extractor and extracted with 500 mL of butyl acetate. Continue the extraction until the refluxed droplet is colorless. The extract was discarded, and the extraction solvent was changed to 5...

Embodiment 2

[0054] Example 2: Preparation of personal care and cosmetic compositions within the scope of the present invention.

[0055] According to the basic formula in Table 1 and Table 2, heat component A to 70-85℃ under stirring. In a separate vessel, heat component B to 70-85°C as well. Add component A to component B with stirring, and stir the mixture at 70-85°C for 30 minutes, then cool.

[0056] Table 1: Component A Formulation

[0057] Element weight% Stearyl Palmitate 6 Octanoic Acid C12-C15 Alkyl Ester 3 PEG-100 stearate 2 Glyceryl Hydroxystearate 1.5 stearyl alcohol 1.5 stearic acid 3 Dimethicone 1 Sorbitan monostearate 1 Vitamin E 0.1

[0058] Table 2: Part B Formulation

[0059] Element weight% Magnesium Aluminum Silicate 0.5 Simethicone 0.01 xanthan gum 0.2 Hydroxyethyl cellulose 1 Propylparaben 0.2 Disodium EDTA 0.05 Butylated hydroxytoluene 0.05 ...

Embodiment 3-10

[0061] According to the basic recipe in Table 3, heat component A to 70-85°C under stirring. In a separate vessel, heat component B to 70-85°C as well. Part A was added to Part B with stirring, and the mixture was stirred at 70-85°C for 30 minutes, then cooled.

[0062] table 3:

[0063]

[0064]

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PUM

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Abstract

The invention discloses a method for industrialized preparing of high-purity Alopecurones from Sophora alopecuroide as a raw material, the preparation of the Alopecurones by the method avoids acid-base treatment and chromatographic separation, thereby avoiding degradation and isomerization of the Alopecurones during the acid-base treatment. The compound purity and yield are increased. The possibletoxicity and skin irritation are reduced. The Alopecurones obtained by the method has better skin brightening activity compared with known skin brightening agents.

Description

technical field [0001] The present invention relates to a preparation method of high-purity bitter soybean ketone, and it is used as a skin lightening agent for personal care in combination with other active compounds and excipients. Background technique [0002] Skin lightening is what many people desire. In order to meet these needs, many manufacturers try to develop products to reduce the production of human skin pigment. However, few high-efficiency and low-toxic chemicals can play such an effect at present. The use of heavy metal ions such as lead or mercury can produce toxicity or skin irritation. Therefore, personal care products or cosmetics that utilize natural chemical ingredients to achieve whitening effects are the pursuit of many consumers. [0003] Japanese patent application JP07-188245A (Mukenazu) relates to compounds contained in "Kukanzo", which can be used as MRSA (anti-methicillin Staphylococcus aureus) antibacterial agent, anticancer active agent, ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04A61K8/49A61Q19/02
CPCA61K8/498A61Q19/02C07D493/04
Inventor 沈征武
Owner YUN BAI YAO ZHENG WU TECH SHANGHAI CO LTD