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Blood transfusion bag material with blood stabilization function and preparation method of blood transfusion bag material

A blood transfusion bag and stable technology are applied in the field of materials for blood transfusion bags with blood stabilization function and their preparation, which can solve the problems that blood compatibility and comprehensive performance need to be further improved, short storage time of whole blood and red blood cells, and temperature resistance. It needs to be further improved to achieve the effect of improving blood stability, reducing blood toxicity and improving plasticity

Inactive Publication Date: 2019-12-10
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As an improvement, literature and patents have reported some other non-PVC blood bag materials, such as linear low-density polyethylene / styrene-ethylene-butadiene-styrene copolymer blends, etc., but these materials are due to blood compatibility And the comprehensive performance needs to be further improved and other reasons have not been commercialized
The infusion bag materials in the prior art are more or less unfavorable to blood stability, the storage time of whole blood and red blood cells in it is short, the potential harm to human health is relatively large, the production process is complicated, the production cost is high, and the durability The temperature needs to be further improved, and it cannot be used in an environment with mold, and there are very large uncertainties in the safety of blood transfusion.

Method used

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  • Blood transfusion bag material with blood stabilization function and preparation method of blood transfusion bag material
  • Blood transfusion bag material with blood stabilization function and preparation method of blood transfusion bag material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A blood transfusion bag material with blood stabilizing function, made of the following raw materials in parts by weight: 45 parts of tris(trimethylsilyl)amine ionized modified PVC, bis(β-D-xylose)amine modified 40 parts of PVC, 3 parts of L-dierucoyl lecithin, 1 part of azobisisobutyronitrile, 5 parts of vinyl silicone oil, and 2 parts of epoxy soybean oil.

[0030] The preparation method of the two (β-D-xylose) amine modified PVC comprises the steps of: dissolving 100 g of polyvinyl chloride (PVC) in 1800 g of dimethyl sulfoxide to form a solution, and then adding two (β -D-xylose)amine 450g and sodium carbonate 40g, stirred and reacted at 60°C for 5 hours, filtered to remove insoluble matter after the reaction, then precipitated in water, washed the product 3 times with ethanol, and placed in a vacuum drying oven 85 Dry to constant weight at ℃ to obtain di(β-D-xylose)amine modified PVC.

[0031] The preparation method of described three (trimethylsilyl) amine ioniza...

Embodiment 2

[0036] A blood transfusion bag material with blood stabilizing function, made of the following raw materials in parts by weight: 50 parts of tris(trimethylsilyl) amine ionized modified PVC, bis(β-D-xylose) amine modified 42 parts of PVC, 4 parts of L-dierucoyl lecithin, 1.5 parts of azobisisoheptanonitrile, 6 parts of vinyl silicone oil, and 2.5 parts of tributyl citrate.

[0037] The preparation method of described two (beta-D-xylose) amine modified PVC comprises the steps of: dissolving polyvinyl chloride (PVC) 100g in N,N-dimethylformamide 1900g to form a solution, and then adding to the solution Add 450 g of di(β-D-xylose) amine and 50 g of potassium carbonate, stir and react at 65° C. for 6 hours, remove the insoluble matter by filtration after the reaction is completed, then precipitate in water, wash the product 4 times with ethanol, and place Dry in a vacuum oven at 87°C until constant weight to obtain di(β-D-xylose)amine-modified PVC.

[0038] The preparation method ...

Embodiment 3

[0043] A blood transfusion bag material with blood stabilizing function, made of the following raw materials in parts by weight: 53 parts of tris(trimethylsilyl) amine ionized modified PVC, bis(β-D-xylose) amine modified 45 parts of PVC, 5 parts of L-dierucoyl lecithin, 2 parts of cyclohexanone peroxide, 6.5 parts of vinyl silicone oil, and 3 parts of epoxy linseed oil.

[0044] The preparation method of described two (beta-D-xylose) amine-modified PVC comprises the steps of: dissolving polyvinyl chloride (PVC) 100g in N, N-dimethylacetamide 2100g to form a solution, and then adding to the solution Add 450 g of di(β-D-xylose) amine and 55 g of sodium hydroxide to the mixture, stir and react at 70° C. for 6.5 hours, remove the insoluble matter by filtration after the reaction is completed, then precipitate in water, wash the product 4 times with ethanol, and then Place in a vacuum oven at 89°C and dry to constant weight to obtain di(β-D-xylose)amine modified PVC.

[0045] The ...

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PUM

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Abstract

The invention discloses a blood transfusion bag material with a blood stabilization function. The blood transfusion bag material is characterized by being prepared from the following raw materials inparts by weight: 45-60 parts of tri(trimethyl silicon) amine ionization modified PVC (polyvinyl chloride), 40-50 parts of di(beta-D-xylose) amine modified PVC, 3-7 parts of L-dierucoyl phosphatidylcholine, 1-3 parts of an initiator, 5-8 parts of vinyl silicon oil and 2-4 parts of a plasticizer. The invention further provides a preparation method of the blood transfusion bag material with the bloodstabilization function. The blood transfusion bag material with the blood stabilization function, which is disclosed by the invention, is good in blood compatibility, capable of effectively improvingblood stability, prolonging the storage time of whole blood and red blood cells, excellent in mechanical property, high in light permeability, good in weather resistance and chemical reagent resistance and safe and reliable in blood transfusion.

Description

technical field [0001] The invention relates to the technical field of materials for blood transfusion bags, in particular to a material for blood transfusion bags with blood stabilizing function and a preparation method thereof. Background technique [0002] When rescuing patients, especially when operating or rescuing trauma patients, blood transfusion is a common treatment. Ensuring blood safety is the key to determining the rescue effect and reducing mortality. The performance of the materials used in blood transfusion bags directly affects the safety of blood. It can be seen that it is extremely urgent to develop materials for blood transfusion bags with excellent performance, which is of great significance to promote blood transfusion safety and prevent blood from being polluted. [0003] The current common medical blood transfusion bags are disposable plastic blood bags, which have always been the most important container for storing blood components. The material ...

Claims

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Application Information

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IPC IPC(8): C08L27/22C08L83/07C08L91/00C08K5/521C08F8/00C08F8/42C08F14/06A61J1/10
CPCA61J1/10C08F8/00C08F8/42C08L27/22C08L2203/02C08L2205/035C08L83/04C08L91/00C08K5/521C08F14/06
Inventor 万迎春苏秦
Owner 湖南博隽生物医药有限公司