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Nuclear magnetic resonance imaging-guided photo-thermal and photodynamic diagnosis and treatment integrated reagent and preparation method thereof

A nuclear magnetic resonance imaging and photothermal technology, which is applied in the fields of material science and biomedicine, can solve the problems that the treatment methods are difficult to achieve the ideal therapeutic effect, and achieve the effect of improving the photothermal performance

Active Publication Date: 2019-12-13
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the specificity and recurrence of tumor cells, it is difficult to achieve the ideal therapeutic effect with a single treatment method. Therefore, combining PDT and PTT to treat tumors can achieve a more ideal tumor clearance effect

Method used

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  • Nuclear magnetic resonance imaging-guided photo-thermal and photodynamic diagnosis and treatment integrated reagent and preparation method thereof
  • Nuclear magnetic resonance imaging-guided photo-thermal and photodynamic diagnosis and treatment integrated reagent and preparation method thereof
  • Nuclear magnetic resonance imaging-guided photo-thermal and photodynamic diagnosis and treatment integrated reagent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] 1) Synthesis of gold nanoparticles (GNS): 250 μL of 20 mg / mL HAuCl 4 The solution was added dropwise to 25 mL of 100 mg / mL 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid semi-sodium salt (HEPES) buffer solution, allowed to stand at room temperature, solid-liquid separation, and frozen After freeze-drying in a dryer, GNS solid powder is obtained;

[0039] 2) Synthesis of MoS 2 -PVP-coated Au: Completely disperse 5mg of gold nanoparticles in step 1) into 5mL of deionized water to form a gold nanoparticle solution, and then add it to 1mL of Na 2 MoO 4 (170mg / mL) and 0.5mL of L-cysteine ​​(L-cys) (245mg / mL) mixed solution, then add 5mL 0.02mg / mL polyvinylpyrrolidone (PVP) dropwise, after mixing well, Carry out the reaction, wash alternately with ethanol and deionized water, and finally disperse in 10mL deionized water for later use;

[0040] 3) Synthesis of MoS 2 -chitosan coated Gd-Au (GGMC): 1mLGdCl 3 solution (5mg / mL) was added to the 10mL MoS described in step...

Embodiment 2

[0042] 1) Synthesis of gold nanoparticles (GNS): 250 μL of 20 mg / mL HAuCl 4 The solution was added dropwise to 25 mL of 100 mg / mL 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid semi-sodium salt (HEPES) buffer solution, allowed to stand at room temperature, solid-liquid separation, and frozen After freeze-drying in a dryer, GNS solid powder is obtained;

[0043] 2) Synthesis of MoS 2 -PVP-coated Au: Completely disperse 5mg of gold nanoparticles in step 1) into 5mL of deionized water to form a gold nanoparticle solution, and then add it to 1mL of Na 2 MoO 4 (170mg / mL) and 0.5mL of L-cysteine ​​(L-cys) (245mg / mL) mixed solution, then add 5mL 0.02mg / mL polyvinylpyrrolidone (PVP) dropwise, after mixing well, Carry out the reaction, wash alternately with ethanol and deionized water, and finally disperse in 10mL deionized water for later use;

[0044] 3) Synthesis of MoS 2 -chitosan coated Gd-Au (GGMC): 1mLGdCl 3 solution (5mg / mL) was added to the 10mL MoS described in step...

Embodiment 3

[0046] 1) Synthesis of gold nanoparticles (GNS): 250 μL of 20 mg / mL HAuCl 4 The solution was added dropwise to 25 mL of 100 mg / mL 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid semi-sodium salt (HEPES) buffer solution, allowed to stand at room temperature, solid-liquid separation, and frozen After freeze-drying in a dryer, GNS solid powder is obtained;

[0047] 2) Synthesis of MoS 2 -PVP-coated Au: Completely disperse 5mg of gold nanoparticles in step 1) into 5mL of deionized water to form a gold nanoparticle solution, and then add it to 1mL of Na 2 MoO 4 (170mg / mL) and 0.5mL of L-cysteine ​​(L-cys) (245mg / mL) mixed solution, then add 5mL 0.02mg / mL polyvinylpyrrolidone (PVP) dropwise, after mixing well, Carry out the reaction, wash alternately with ethanol and deionized water, and finally disperse in 10mL deionized water for later use;

[0048] 3) Synthesis of MoS 2 -chitosan coated Gd-Au (GGMC): 1mLGdCl 3 solution (5mg / mL) was added to the 10mL MoS described in step...

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Abstract

The invention provides a nuclear magnetic resonance imaging-guided photo-thermal and photodynamic diagnosis and treatment integrated reagent and a preparation method thereof. The two-dimensional lamellar molybdenum sulfide grows on the surfaces of the nano-gold particles, and the nano-gold particles and the molybdenum sulfide lamellar layer are compounded, so that the nano-particles can promote decomposition of hydrogen peroxide and generate reactive oxygen species (ROS) with cytotoxicity, and a PDT and PTT combined treatment effect is achieved. Then, the surface of molybdenum sulfide is modified with Gd <3+>, the nanoparticle is endowed with a magnetic resonance imaging (MRI) radiography function, and the purpose of diagnosis and treatment integration is achieved. Finally, the chitosan isused for coating the nano particles, so that the nano particles not only have good dispersity, but also have excellent biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of material science and biomedicine, and in particular relates to an integrated reagent for photothermal and photodynamic diagnosis and treatment guided by nuclear magnetic resonance imaging and a preparation method thereof. Background technique [0002] In recent years, nanomaterials integrating diagnosis and treatment have a significant therapeutic effect on cancer. How to realize the integration of diagnosis and treatment of nanomaterials has very high requirements for the design and synthesis of materials. The rise of imaging technology has greatly promoted the treatment of tumors. For example, technologies such as MRI, CT, photoacoustic imaging, and fluorescence imaging all play an important role in the field of tumor visualization imaging. [0003] Photodynamic therapy (PDT) and photothermal therapy (PTT) are two promising treatments for tumors. Transition metal dichalcogenides (TMDCs), such as MoS ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/36A61K49/18A61P35/00
CPCA61K9/5161A61K41/0052A61K41/0057A61K49/1863A61P35/00A61K2300/00
Inventor 徐祖顺刘豪杰
Owner HUBEI UNIV
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