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Novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels, and extraction method and usage thereof

A technology of stilbene compounds and compounds, applied in the field of new oligomeric stilbene compounds and their extraction, can solve problems such as side effects of patients, and achieve the effects of expanding clinical applications, inhibiting lipid production, and inhibiting lipid droplet accumulation

Active Publication Date: 2019-12-20
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Lipid metabolism disorders such as obesity, high blood pressure, high blood fat, and cardiovascular disease are gradually infringing on people's health, and long-term use of traditional therapeutic drugs will have side effects on the patient's body. Therefore, it is urgent to develop safer and more effective natural plants source of drug

Method used

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  • Novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels, and extraction method and usage thereof
  • Novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels, and extraction method and usage thereof
  • Novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels, and extraction method and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The preparation of embodiment 1 oligomeric stilbene class novel compound

[0084] (1) washing the seeds of Rhizoma rhizome after removing impurities with pure water, drying in the shade, peeling, and pulverizing to 30 orders to obtain the raw material of seed kernels of Rhizoma rhizome;

[0085] (2) 22kg of Sizum officinalis seeds were soaked and extracted at room temperature for 12h with 5% NaOH, wherein the 5% NaOH solution was 3kgNaOH dissolved in 60L of ultrapure water, and the extract was collected by filtration;

[0086] (3) Add dilute H to the extract obtained in step (2) 2 SO 4 solution, adjusted to PH=3, and allowed to stand at room temperature for 1 hour to cause precipitation;

[0087] (4) Collect the precipitate produced in step (3) and centrifuge at room temperature, the centrifugation condition is: 4500rpm, 10min, collect the precipitate obtained;

[0088] (5) Dissolve the acid precipitate collected in step (4) with 12L of 95% ethanol to fully dissolve ...

Embodiment 2

[0100] The preparation of embodiment 2 oligomeric stilbene class novel compounds

[0101] (1) washing the seeds of Rhizoma rhizome after removing impurities with pure water, drying in the shade, peeling, and pulverizing to 30 orders to obtain the raw material of seed kernels of Rhizoma rhizome;

[0102] (2) Soak 22kg of Sizum officinalis seed kernels in 10% NaOH at a normal temperature for 8 hours, wherein the 10% NaOH solution is 6kg NaOH dissolved in 60L of ultrapure water, and the extract is collected by filtration;

[0103] (3) Add hydrochloric acid dropwise to the extract obtained in step (2), adjust the pH to 3, and let it stand at room temperature for 1 hour to cause precipitation;

[0104] (4) Collect the precipitate produced in step (3) and centrifuge at room temperature, the centrifugation condition is: 4500rpm, 10min, collect the precipitate obtained;

[0105] (5) Dissolve the acid precipitate collected in step (4) with 12L of methanol to fully dissolve it;

[010...

Embodiment 3

[0111] The preparation of embodiment 3 oligomeric stilbene class novel compounds

[0112] (1) washing the seeds of Rhizoma rhizome after removing impurities with pure water, drying in the shade, peeling, and pulverizing to 30 orders to obtain the raw material of seed kernels of Rhizoma rhizome;

[0113] (2) 22kg of Sizum officinalis seeds were soaked and extracted at room temperature with 1% NaOH for 18h, wherein the 1% NaOH solution was 0.6kgNaOH dissolved in 60L of ultrapure water, and the extract was collected by filtration;

[0114] (3) Add dilute H to the extract obtained in step (2) 2 SO 4 solution, adjusted to PH=3, and allowed to stand at room temperature for 1 hour to cause precipitation;

[0115] (4) Collect the precipitate produced in step (3) and centrifuge at room temperature, the centrifugation condition is: 4500rpm, 10min, collect the precipitate obtained;

[0116] (5) Dissolve the acid precipitate collected in step (4) with 12L of 95% ethanol to fully dissol...

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Abstract

The invention discloses novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels as well as an extraction method and usage thereof. The extraction method of the novel stilbene compound oligomers in the sword iris seed kernels comprises the following steps: performing amplified preparation on an alkali extracted and acid precipitated product of sword iris seed kernels; and then, carrying out two times of preparation by adopting an aqueous cetonitrile solution as mobile phase so as to obtain the novel stilbene compound oligomers S11 in thesword iris seed kernels, namely VitisinA-13b-o-glucoside. The invention further provides application of the new compound S11 in preparation of medicines used for preventing and / or treating lipid metabolism disorder. And moreover, inhibition of cell lipogenic differentiation and lipogenesis by the novel stilbene compound oligomers S11 is verified by studying activity of the novel stilbene compoundoligomers S11; so that, the novel stilbene compound oligomers S11 can be used for preparing medicines which are capable of preventing or treating metabolic disorders, such as obesity, hyperlipidemia and the like.

Description

technical field [0001] The invention relates to the field of oligomeric stilbene compounds in the seed kernels of Scutellaria japonicus and the field of their medical applications, in particular to new oligostilbene compounds in the kernels of Scutellaria japonicus and their extraction method and application. Background technique [0002] Stilbene compounds are a general term for a class of compounds having a 1,2-stilbene skeleton and polymers composed of it. It mainly exists in the xylem of plants, and was first discovered from the Polygonaceae plant Rhubarb, including stilbene, diphenylethyl, phenanthrene monomers and their polymers. Oligomeric stilbene compounds belong to non-flavonoid polyphenolic compounds, which are found in Gentianaceae, Paeoniaceae, Materiaceae, Rosaceae, Cyperaceae, Fabaceae, Moraceae, Papilionaceae, Iridaceae, Grapes, etc. In recent years, studies have reported that stilbene compounds have a variety of biological activities, such as neuroprotecti...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08A61P3/04A61P9/12A61P9/00A61P3/06A61P3/00
CPCC07H17/04C07H1/08A61P3/04A61P9/12A61P9/00A61P3/06A61P3/00Y02A50/30
Inventor 王洪伦铁芳芳
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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