Preparation method of mesoporous silica long-acting antibacterial nano-materials with high selenium loading amount

A technology of mesoporous silica and nanomaterials, which is applied in the fields of botanical equipment and methods, chemicals for biological control, plant growth regulators, etc., can solve the problem that selenium cannot be uniformly loaded in large quantities, and achieve good bactericidal effect. , Enlarged aperture, the effect of controllable size

Active Publication Date: 2020-02-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a preparation method of mesoporous silica long-acting antibacterial nanomaterials with h

Method used

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  • Preparation method of mesoporous silica long-acting antibacterial nano-materials with high selenium loading amount
  • Preparation method of mesoporous silica long-acting antibacterial nano-materials with high selenium loading amount
  • Preparation method of mesoporous silica long-acting antibacterial nano-materials with high selenium loading amount

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Select analytically pure sodium selenite, ascorbic acid, cetyltrimethylammonium bromide (CTAB, Sinopharm Group Industry Co., Ltd.), ammonium fluoride (NH 4 F, Sinopharm Group Industry Co., Ltd.), tetraethyl orthosilicate (TEOS, Sinopharm Group Industry Co., Ltd.), and Se-MSNs with a Se loading of 30wt.% were synthesized by this preparation method. The specific steps are:

[0044] Weigh 0.90g CTAB, 1.50g NH 4 F, then add 250mL of deionized water, the reaction temperature is 80°C, stir well for 1h, the rotor speed is controlled at 200-300rpm; after 1h of reaction, add 1.8mL of TEOS dropwise to the reaction system, continue the reaction for 1h, then cool to room temperature The sample was centrifuged, and the white powder obtained by freeze-drying the precipitate was calcined in a muffle furnace at 600°C for 5 hours to remove CTAB in MSNs; 1.59g of anhydrous sodium carbonate was dissolved in 50mL of deionized water to obtain a concentration of 0.3mol / L under stirring con...

Embodiment 2

[0047] Se-MSNs with a selenium loading of 20wt.% were synthesized by this preparation method. The specific steps are:

[0048] The preparation method of the expanded MSNs is the same as in Example 1.

[0049] According to Example 1, the amount of sodium selenite was changed to 0.25g, the amount of ascorbic acid was changed to 0.75g, and the rest were the same as in Example 1 to obtain red powder 20wt.%Se-MSNs.

[0050] After testing, the results of its antibacterial properties are similar to those of Example 1.

Embodiment 3

[0052] Se-MSNs with a selenium loading of 35wt.% were synthesized by this preparation method. The specific steps are:

[0053] The preparation method of the expanded MSNs is the same as in Example 1.

[0054] According to Example 1, the amount of sodium selenite was changed to 0.437g, the amount of ascorbic acid was changed to 1.29g, and the rest were the same as in Example 1 to obtain a red powder of 35wt.% Se-MSNs.

[0055] After testing, the results of its antibacterial properties are similar to those of Example 1.

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Abstract

The invention relates to a preparation method of mesoporous silica long-acting antibacterial nano-materials with the high selenium loading amount. The preparation method comprises the steps: preparation of pore-expanded mesoporous silica, preparation of a selenium source and ascorbic acid mixed solution, and preparation of the selenium-loading mesoporous silica antibacterial nano-materials. The Se-MSNs obtained through the method are high in selenium loading amount, high in adjustability and controllability and good in dispersity, particles are uniform, pore passages of the Se-MSNs can be fully filled with Se, compared with pure Se, particles of the Se-MSNs have the obvious advantage in the aspect of dispersity, and thus the Se-MSNs have the characteristics of long-acting release, durablebacterium resistance and the like and are expected to serve as a novel non-toxic and harmless long-acting antibacterial material.

Description

technical field [0001] The invention belongs to the field of preparation of antibacterial materials, in particular to a preparation method of mesoporous silicon dioxide long-acting antibacterial nanometer material with high selenium loading. Background technique [0002] As one of the essential trace elements for the human body, selenium is a component of various enzymes in the human body. For a long time, it has played an important role in anti-cancer, antagonizing heavy metals, and enhancing human immune function. Studies have shown that selenium nanoparticles combined with acetylcholine chloride and quercetin have high antibacterial and bactericidal activity against superbugs, and will not produce drug resistance. In addition, studies have found that nano-selenium coatings on hydroxyapatite have good antibacterial properties against Pseudomonas aeruginosa and Staphylococcus aureus. From the perspective of biological safety, the endogenous selenium element has more relia...

Claims

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Application Information

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IPC IPC(8): A01N59/02A01N59/00A01P1/00
CPCA01N59/00A01N59/02
Inventor 倪似愚陈晶晶魏媛媛杨雪霞金熙江浩
Owner DONGHUA UNIV
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