Acne-removing composition and preparation method thereof

A composition and acne technology, applied in the direction of drug combination, skin care preparations, medical preparations containing active ingredients, etc., can solve the problem that alcohol-soluble components cannot be effectively extracted, 5α-reductase is not considered, and cannot be effective The components are fully extracted to achieve the effect of inhibiting Propionibacterium acnes, improving the utilization rate of medicinal materials, and increasing the specific surface area

Active Publication Date: 2020-02-14
广州伽能生物科技有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

This method uses water as the extraction solvent, and cannot achieve the so-called "full component extraction", that is, the effective components in the medicinal materials cannot be fully extracted
Traditional Chinese medicine extraction is based on the principle of similarity and compatibility. Water extraction can extract most of the water-soluble components, but there are still many alcohol-soluble components that cannot be effectively extracted, and these components also have obvious effects in antibacterial, anti-inflammatory, and oil control. ; At the same time, the patent only carried out the proportional deployment of medicinal materials, extraction, membrane separation and concentration for the prescription, but did not carry out quality control
As we all know, the various ingredients in traditional Chinese medicine will cause great differences due to the origin of the medicinal materials, harvest season, storage time, processing methods, etc. If the quality of the product is not controlled, that is, the content of active ingredients, the product will not work properly. The expected effect is more likely to increase the cost of impurity removal due to the subsequent extraction of a large amount of impurities due to the wall-breaking treatment in the pretreatment method
[0006] CN108210446 and other patents use Yiwan Company’s “Acne Buster” as an effective ingredient for acne-removing cosmetics. The “Acne Buster” contains 5.6% glycolic acid, 1% ethylhexylglycerin, 1% caprylic acid, and barkberry 0.125% extract, and several other components can inhibit Propionibacterium acnes and Staphylococcus aureus, and inhibit inflammatory factors. Failure to consider the effect of 5α-reductase on oil secretion is one of the main factors affecting acne

Method used

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  • Acne-removing composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Put 20 parts of Cortex Phellodendron into a pulverizer, crush it to a size of 80 mesh or less (sieve); put in pure water 6 times the weight of the medicinal material, and stir to suspend and disperse the particles;

[0045] 2. Jet cooking the material liquid in 1, the material is in the middle, steam is injected from both sides, the steam outlets on both sides are at an angle of 120°, the steam temperature is 140°C, the material flow rate is 15L / min, and the steam flow rate on both sides is 20L / min min;

[0046] 3. Pour the material liquid in 2 into the colloid mill, the grinding gap gradually decreases from the maximum (the gap finally reaches 1 micron), heat the material liquid to 40°C, add cellulase according to 0.8% of the weight of the medicinal material (enzyme activity unit 10000 U / g), adjust the pH to 4.5, stir for enzymolysis and grind for 60 minutes;

[0047] 4. Add butanediol which is 6 times the weight of Phellodendron cortex in 1, and 20 parts of thyme...

Embodiment 2

[0053] 1. Put 15 parts of Cortex Phellodendron into a pulverizer, crush it to less than or equal to 80 mesh (sieve); put in pure water 4 times the weight of the medicinal material, and stir to suspend and disperse the particles;

[0054] 2. Put the material liquid in 1 into the steam injection device for jet cooking, the steam temperature is 120°C, the material flow rate is 20L / min, and the steam flow rate on both sides is 25L / min;

[0055] 3. Pour the material liquid in 2 into the colloid mill, the grinding gap gradually decreases from the maximum (the gap finally reaches 1 micron), heat the material liquid to 30°C, add cellulase according to 0.1% of the weight of the medicinal material (enzyme activity unit 10000 U / g), adjust the pH to 5.5, stir and grind for 60 minutes;

[0056] 4. Add butanediol which is 4 times the weight of Phellodendron cortex in 1, and 15 parts of thyme, mix well, continue grinding and extracting at 55°C for 0.5h;

[0057] 5. Use qualitative filter p...

Embodiment 3

[0060] 1. Put 17.5 parts of Cortex Phellodendron into a pulverizer, crush to a size of 80 mesh or less (sieve); put in pure water 5 times the weight of the medicinal material, and stir to suspend and disperse the particles;

[0061] 2. Put the material liquid in 1 into the steam injection device for jet cooking, the steam temperature is 130°C, the material flow rate is 18L / min, and the steam flow rate on both sides is 22L / min;

[0062] 3. Pour the material liquid in 2 into the colloid mill, the grinding gap gradually decreases from the maximum (the gap finally reaches 1 micron), heat the material liquid to 50°C, add cellulase according to 0.5% of the weight of the medicinal material (enzyme activity unit 10000 U / g), adjust the pH to 4.0, stir for enzymolysis and grind for 60 minutes;

[0063] 4. Add butanediol which is 4 times the weight of Phellodendron cortex in 1, and 17.5 parts of thyme, mix well, continue grinding and extracting at 30°C for 0.5h;

[0064] 5. Use qualita...

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Abstract

The present invention discloses an acne-removing composition and a preparation method thereof. The composition comprises a compound traditional Chinese medicine extract, 10-25 parts by mass of glycolic acid, 0.1-0.9 part by mass of glyceryl monocaprylate and 0.1-0.9 part by mass of ethylhexyl glycerol, and the compound traditional Chinese medicine extract is a phellodendron amurense bark extract and a thyme extract. Through specific spraying and cooking pretreatment, grinding and enzymolysis, a cellulose structure of phellodendron amurense is efficiently and fully destroyed, active substance activity is better retained, and middle and low-temperature grinding and extracting of active ingredients of the compound traditional Chinese medicines are conducted, so that the traditional Chinese medicine extract is relatively better in drug activity under a relatively low dose. By compounding the glycolic acid, glyceryl monocaprylate, and ethylhexyl glycerol, the acne-removing composition can reduce use amount of the extract, can also accelerate the time of onset, completely eliminates cause of diseases and also helps the skin to restore a healthy state.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a composition for removing acne and a preparation method thereof. Background technique [0002] Acne, also known as acne vulgaris, is a chronic inflammation of the pilosebaceous glands that usually occurs on the face, chest and shoulder blades. Mild acne is a characteristic of most young people's skin during puberty. More than 80% of teenagers have suffered from acne. Acne varies from person to person. Some people have mild symptoms during puberty, and the symptoms gradually subside after puberty. However, there are also a large number of people who suffer from acne due to improper treatment of acne in the early stage or other physiological and environmental reasons. It will aggravate the symptoms, even after puberty, it will continue to recur for a long time. Severe acne can develop into pustules and cysts, and also leave scars after subsiding, which brings great physical and mental ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61K8/36A61K8/37A61Q19/00A61P17/10
CPCA61K8/9789A61K8/345A61K8/36A61K8/375A61Q19/00A61P17/10A61K2800/805A61K2800/5922A61K2800/592
Inventor 陈贤
Owner 广州伽能生物科技有限公司
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