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Compositions containing cationic compound, preparation method of skin external preparation, skin external preparation and application of compositions

A technology of cationic compounds and anionic polymers, applied in the field of compositions containing cationic compounds, can solve problems such as limiting the application of cationic compounds

Inactive Publication Date: 2020-02-21
上海尤文化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is to overcome the defects in the prior art that cationic compounds, such as cetylpyridinium chloride, etc., are easy to produce insoluble precipitates after mixing with anionic surfactants or anionic polymers, which limits the application of cationic compounds, and provides Composition containing cationic compound, preparation method, skin external preparation and application

Method used

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  • Compositions containing cationic compound, preparation method of skin external preparation, skin external preparation and application of compositions
  • Compositions containing cationic compound, preparation method of skin external preparation, skin external preparation and application of compositions
  • Compositions containing cationic compound, preparation method of skin external preparation, skin external preparation and application of compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] After mixing the cetylpyridinium chloride, surfactant and water of each group according to the mass ratio shown in Table 1, the pH was adjusted to 7.0 with citric acid or sodium hydroxide. Take 100mL of liquid from each group, add 0.1g xanthan gum powder, stir at room temperature for 1 hour, place in a 48°C incubator, observe the system and detect its turbidity after 24 hours. The results can be seen in Table 1.

[0145] Table 1

[0146] w / w% Example 1-1 Example 1-2 Example 1-3 Example 1-4 Cetyl pyridinium chloride 0.1 0.1 0.1 0.1 PPG-5-Ceteth-10 Phosphate 0.5 / / / Oleth-5 Phosphate / 0.5 / / Laureth-7 Citrate / / 0.5 / Sodium Laureth-2 Sulfate / / / 10 Dosage of citric acid / / / 0.24 Dosage of sodium hydroxide 0.02 0.03 0.03 / xanthan gum 0.1 0.1 0.1 0.1 water to 100% to 100% to 100% to 100% system state Transparent liquid Transparent liquid Transparent li...

Embodiment 2

[0151] The compositions of each group shown in Table 2 were mixed and prepared by the method in Example 1, and the system conditions, Brookfield viscosity and turbidity are shown in Table 2.

[0152] Table 2

[0153]

[0154] As can be seen from Table 2, comparing Example 2-1 with matched group 1, Example 2-2 with matched group 2, and Example 2-3 with matched group 3, cetylpyridinium chloride and oleth-5 The composition of the phosphate ester salt has almost no effect on the viscosity and turbidity of different types of anionic polymers, and can maintain a transparent state in different types of anionic polymer systems.

Embodiment 3

[0156] The compositions of each group shown in Table 3 were mixed and prepared by the method in Example 1, and the system state, pH and turbidity are shown in Table 3.

[0157] table 3

[0158]

[0159] It can be seen from Table 3 that the highest mass ratio of cetylpyridinium chloride: laureth-7 citrate salt is 12:35, and the system containing cationic compounds and anionic polymers can remain transparent. Different types of bases have no effect on the transparency of the system. The pH range of the system is 5-9.5, which is the usual range of skin care products.

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Abstract

The invention discloses compositions containing a cationic compound, a preparation method of a skin external preparation, the skin external preparation and an application of the compositions. One composition includes the following components: the cationic compound and a surfactant I; and a structural general formula of the surfactant I is R1-(M1)m-(N1)n-A1, wherein R1 is C10-C18 alkyl, M1 is a polyethylene glycol chain, N1 is a polypropylene glycol chain, m is any integer of 2 to 10, n is any integer of 0 to 10, and A1 is a dibasic acid ester salt or a polybasic acid salt. After the compositions containing the cationic compound provided by the invention are added to an anionic system, especially an anionic polymer system, a transparent and non-precipitating system can be obtained; and theprepared skin external preparation is still transparent and stable after being left for 3 months under accelerated test conditions, can meet the requirements of skin external preparations, has good antiseptic ability and no irritation to skin, and is safe to use.

Description

technical field [0001] The invention relates to a composition containing a cationic compound, a preparation method, an external skin preparation and application. Background technique [0002] According to the "Safety and Technical Specifications for Cosmetics", the restricted preservatives in cosmetics include 51 compounds, mainly divided into organic acids, aromatic alcohols, halogens, formaldehyde releasers, isothiazolinones, and paraben esters and cations. Among them, halogens, formaldehyde releasers, isothiazolinones and paraben esters have certain safety problems, and their usage has been gradually restricted or included in the prohibited list in the revision of regulations in recent years, which makes it safe to use There are fewer and fewer preservatives. [0003] Cetylpyridinium chloride is a quaternary ammonium cationic surfactant that can interact with negatively charged groups on the cell wall to increase cell permeability and kill bacteria. Because it is non-i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/86A61K8/41A61K8/42A61K8/49A61K8/55A61Q19/00A61K47/22A61K47/24A61K47/18
CPCA61K8/416A61K8/42A61K8/4926A61K8/556A61K8/86A61K47/186A61K47/22A61K47/24A61K2800/10A61K2800/524A61K2800/596A61Q19/00
Inventor 任昌昊朱汉超顾卫兵
Owner 上海尤文化工有限公司
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