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Sticky antibacterial repair material and preparation method and application thereof

A repair material and a sticky technology, which are applied in the field of sticky antibacterial repair materials and their preparation, can solve the problems of drug rubbing off, difficulty in sticking to the affected area, etc., and achieve accelerated healing, good tissue compatibility, and convenient use. Effect

Pending Publication Date: 2020-03-27
四川艾医生医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult for these antibacterial repair materials to stick to the affected area and achieve continuous antibacterial repair. At the same time, the phenomenon of drug rubbing will inevitably occur, which brings a lot of inconvenience to patients.

Method used

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  • Sticky antibacterial repair material and preparation method and application thereof
  • Sticky antibacterial repair material and preparation method and application thereof
  • Sticky antibacterial repair material and preparation method and application thereof

Examples

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Comparison scheme
Effect test

preparation example Construction

[0035] The invention also provides a preparation method of an adhesive antibacterial restoration material, and the preparation method includes the following steps.

[0036] Step A:

[0037] Under sterile conditions, mix purified water, humectant and D-panthenol evenly, add modified chitosan and forming agent and mix evenly, then add bioactive glass, preservatives and functional additives and mix evenly to obtain a mixed solution, Use a pH regulator to adjust the pH value of the mixture to 3.5-5.5, sterilize it at 120-125°C and cool it for later use; or, under sterile conditions, add a forming agent to purified water and heat, mix and dissolve, After cooling, add humectant and D-panthenol and mix evenly, then add modified chitosan and mix evenly, then add bioactive glass, preservatives and functional additives and mix evenly to obtain a mixed solution, and use a pH regulator to adjust the pH of the mixed solution. Adjust the pH value to 3.5-5.5, sterilize at 120-125°C and cool...

Embodiment 1

[0048] In this example, an adhesive antibacterial repair film for the treatment of oral ulcers was obtained, which was prepared according to the following mass percentages: mussel mucin 0.18%, D-panthenol 0.2%, modified chitosan 10%, bioactive glass 0.5%, 10% forming agent, 30% moisturizing agent, 0.5% preservative, 4% protein protecting agent, 5% pH regulator, 13% functional auxiliary agent and the balance of purified water.

[0049] The molding agent is polyvinyl alcohol, the humectant is glycerin and dodecyl, the preservative is dehydroacetic acid, the protein protection agent is human serum albumin, the pH regulator is ethyl acetate, and the modified chitosan is chitosan quaternary Ammonium salt, functional additives are a mixture of trace element solutions including zinc, iron, selenium, copper, etc., hyaluronic acid and urea sac.

[0050] The preparation of this embodiment comprises the following steps:

[0051] (1) Sterilize all instruments;

[0052] (2) Dissolve poly...

Embodiment 2

[0056] In this example, the sticky antibacterial repair film for the treatment of oral ulcers was prepared according to the following mass percentages: mussel mucin 0.16%, D-panthenol 2%, modified chitosan 5%, bioactive glass 5%, 6% forming agent, 25% moisturizing agent, 0.7% preservative, 3% protein protecting agent, 2.6% pH regulator, 20% functional additive and the balance of purified water.

[0057] The forming agent is polyvinyl alcohol, the moisturizing agent is sorbitol and dodecyl, the preservative is dehydroacetic acid, the protein protection agent is human serum albumin, the pH regulator is acetic acid, and the modified chitosan is carboxymethyl chitosan , The functional aid is a mixture of trace element solutions including zinc, iron, selenium, copper, etc., hyaluronic acid and urea capsules.

[0058] The preparation of this embodiment comprises the following steps:

[0059] (1) Sterilize all instruments;

[0060] (2) Dissolve polyvinyl alcohol in purified water, ...

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Abstract

The invention discloses a sticky antibacterial repair material and a preparation method and application thereof. The sticky antibacterial repair material comprises, in percent by mass, 0.15-0.2% of mussel mucin, 0.2-2% of D-panthenol, 0.5-10% of modified chitosan, 0.5-10% of bioactive glass, 0.5-10% of a molding agent, 20-50% of a humectant, 0.3-1% of a preservative, 1-5% of a protein protection agent, 0.5-5% of a pH regulator, 13-30% of a functional auxiliary agent, and the balance purified water. The preparation method comprises the step of sequentially mixing the raw materials under asepticconditions. The sticky antibacterial repair material is directly applied to an affected part in a natural orifice with secretions on the human or animal body to realize functions of antibiosis, repair and healing promotion. The sticky antibacterial repair material can not only realize the antibacterial and repair functions to achieve the purpose of healing, but also is convenient for patients andmedical personnel to use, is small in odor or odorless, is not easy to be wiped off, and is more easily favored by the majority of patients.

Description

technical field [0001] The invention belongs to the technical field of biological antibacterial repair materials, and more specifically relates to an adhesive antibacterial repair material and its preparation method and application. Background technique [0002] Antibacterial repair materials have attracted widespread attention as a material that can not only be antibacterial on the surface but also promote wound healing and achieve repair functions. There are various antibacterial repair liquids, antibacterial repair gels, antibacterial repair creams and other products on the market. However, although these antibacterial repair products can achieve the effect of antibacterial repair to a certain extent, patients often have disadvantages such as inconvenient application of medicine, easy to be wiped off, or strong smell during use. The pharmacological effects of antimicrobial ingredients lead to the emergence of resistance in bacteria, which limits the use of these products...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K47/32A61K47/36A61K38/17A61P31/04A61K31/164A61K31/722A61K33/42
CPCA61K9/006A61K9/06A61K9/0031A61K47/32A61K47/36A61K38/17A61K31/164A61K31/722A61K33/42A61P31/04A61K2300/00
Inventor 黄敏唐迎波
Owner 四川艾医生医疗科技有限公司
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