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Biomimetic hydroxylapatite powder/gelatin/sodium alginate composite 3D print bracket and preparation method thereof

A technology of hydroxyapatite and sodium alginate, which is applied in prosthetics, tissue regeneration, medical science, etc., can solve problems such as unfavorable stem cell growth, promote protein adsorption and nutrient exchange, and induce tissue and blood vessel growth. Intake, promote the effect of regeneration and repair

Active Publication Date: 2020-05-05
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] D.Mao,Q.Li,D.Li,Y.Tan,Q.Che,3D porous poly(epsilon-caprolactone) / 58S bioactive glass-sodium alginate / gelatin hybrid scaffold prepared by a modified melt molding method for bone tissue engineering ,Materials&Design 160 (2018) 1-8. This study used sodium alginate and gelatin as printing ink to promote the repair of bone tissue by loading bioglass, but the alkaline environment generated by the degradation process of bioglass is not conducive to the growth of stem cells

Method used

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  • Biomimetic hydroxylapatite powder/gelatin/sodium alginate composite 3D print bracket and preparation method thereof
  • Biomimetic hydroxylapatite powder/gelatin/sodium alginate composite 3D print bracket and preparation method thereof
  • Biomimetic hydroxylapatite powder/gelatin/sodium alginate composite 3D print bracket and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Preparation of hydroxyapatite powder with hierarchical structure:

[0067] Configured with 24mM (NH4) 2 PO 4 solution, adjust the pH to 6.0 to obtain solution a. 40mmol of Ca(NO 3 ) 2 4H 2 O was added to solution a, fully dissolved, and stirred evenly to obtain solution b. Then add 6mmol of sodium citrate into solution b and stir vigorously to obtain a mixed solution. The mixture was transferred to a polytetrafluoroethylene-lined autoclave, and reacted at 180° C. for 3 h. After centrifugal washing and freeze-drying, the hydroxyapatite powder (ie HA particles) with hierarchical structure was obtained. Under the observation of scanning electron microscope, its appearance was as follows: figure 1 shown. The HA particles have a surface micro-nano hierarchical structure and a hollow structure, and the specific surface area is as high as 106.7m 2 / g.

Embodiment 2

[0069] The preparation of hydroxyapatite powder / gelatin / sodium alginate composite 3D printing scaffold includes the following steps:

[0070] (1) Preparation of hydroxyapatite powder / gelatin / sodium alginate composite slurry: take 5g of gelatin particles, add to 50mL of deionized water, fully magnetically stir, stir evenly, and obtain a concentration of 0.1g / mL gelatin solution; then add 5 g of the HA particles obtained in Example 1, and stir until the HA particles are evenly dispersed in the gelatin solution; add 2.2 g of sodium alginate to the above solution, stir well, and ultrasonically remove air bubbles to obtain printing paste;

[0071] (2) Preparation of biomimetic 3D printing scaffold: put the composite slurry of hydroxyapatite particles / gelatin / sodium alginate (that is, the printing slurry) into the barrel, the diameter of the needle is 0.4mm, and the external dimensions of the scaffold material are designed It is a circle with a diameter of 10mm and a height of 2mm....

Embodiment 3

[0073] The preparation of hydroxyapatite powder / gelatin / sodium alginate composite 3D printing scaffold includes the following steps:

[0074] (1) Preparation of hydroxyapatite powder / gelatin / sodium alginate composite slurry: take 5g of gelatin particles, add them to 50mL of deionized water, and fully magnetically stir to obtain a gelatin solution with a concentration of 0.1g / mL Then add 7.5g of the HA particles obtained in Example 1, and stir until the HA particles are evenly dispersed in the gelatin solution; add 1.8g of sodium alginate to the above solution, stir well, and ultrasonically remove air bubbles, and the printing paste is prepared material;

[0075] (2) Preparation of biomimetic 3D printing scaffold: put the composite slurry of hydroxyapatite particles / gelatin / sodium alginate (that is, the printing slurry) into the barrel, the diameter of the needle is 0.4mm, and the external dimensions of the scaffold material are designed It is a circle with a diameter of 10mm ...

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Abstract

The invention discloses a biomimetic hydroxylapatite powder / gelatin / sodium alginate composite 3D print bracket and a preparation method thereof. The preparation method of the biomimetic 3D bracket comprises the steps of (1) preparing hydroxylapatite powder having a biomimetic classified structure; (2) preparing hydroxylapatite powder / gelatin / sodium alginate composite pulp; and (3) preparing the biomimetic 3D print bracket. According to the biomimetic hydroxylapatite powder / gelatin / sodium alginate composite 3D print bracket and the preparation method thereof disclosed by the invention, a 3D printing technique is utilized, the prepared organic / inorganic composite three-dimensional print bracket is controllable in outside size and good in biocompatibility, components and a multi-level structure of natural bone tissue are sufficiently simulated, and controlled mechanical strength is given to materials; and the micro-nano multi-level structure of the composite bracket has higher osteogenesis activity and osteoinductive, a multi-level pore structure can effectively induce ingrowth of tissue and blood vessels, and regeneration and repair of the bone tissue are promoted.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a bionic apatite powder / gelatin / sodium alginate composite 3D printing bracket and a preparation method thereof. Background technique [0002] With the improvement of living standards and the aggravation of population aging, people's demand for repairing bone defects caused by trauma, bone tumor resection and bone tissue lesions has increased dramatically. Autologous bone grafting is considered to be the gold standard for the treatment of bone defects, but its source is limited, the graft body is difficult to shape, and the implantation site is prone to lesions. Allograft bone is easy to obtain, but its clinical use is greatly limited due to the spread of disease, inactivation during material processing, and ethical disputes. The development of new bone tissue repair materials has brought new hope for the repair of bone defects. [0003] Natural bone is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/22A61L27/20A61L27/50A61L27/56B33Y70/10B33Y80/00B33Y10/00
CPCA61L27/12A61L27/20A61L27/222A61L27/50A61L27/56A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L5/04
Inventor 王迎军徐东杜昶
Owner SOUTH CHINA UNIV OF TECH
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