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Self-cleaning intraocular lens and preparation method thereof

An intraocular lens and self-cleaning technology, applied in intraocular lenses, prostheses, medical science, etc., can solve problems such as easy adhesion of proteins and cells, aggravate the proliferation of inflammatory reactions, affect the visual quality of patients, and achieve enhanced adhesion , prevention of complications, and maintenance of optical clarity

Inactive Publication Date: 2020-05-08
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, protein molecules adsorbed on the surface of the intraocular lens can also cause monocytes to invade, adhere and differentiate into foreign body macrophages, which in turn aggravate the inflammatory response and drive the proliferation and migration of the surrounding residual lens epithelial cells to form posterior capsule opacity (also called posterior cataract), which affects the optical clarity of an intraocular lens implanted in the eye
[0003] At present, the commonly used intraocular lens materials in clinical practice cannot effectively prevent the occurrence of inflammatory reactions after implantation of the intraocular lens due to the surface is easy to adhere to proteins and cells, or has poor adhesion to the posterior capsule. (also known as post-cataract) and other related complications, which affect the visual quality of patients after surgery

Method used

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  • Self-cleaning intraocular lens and preparation method thereof
  • Self-cleaning intraocular lens and preparation method thereof
  • Self-cleaning intraocular lens and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of preparation method of self-cleaning intraocular lens, its concrete steps are:

[0040] (1) Soak the hydrophobic acrylate intraocular lens in sterile double-distilled water and ultrasonically clean it for 5-10 minutes, and then wash it with N 2 Stream dry.

[0041] (2) Put the intraocular lens into the chemical vapor deposition reaction chamber, vaporize the PDMS stock solution into the reaction chamber under vacuum conditions, and heat to 100° C. for 24 hours to react.

[0042] (3) After the reaction, the PDMS-modified intraocular lens was taken out and cooled to room temperature.

[0043] (4) The intraocular lens is sterilized with ethylene oxide and sealed for storage.

[0044] Such as Figure 1 to Figure 4 As shown, the intraocular lens prepared by this method has a surface roughness value of 1.316nm detected by an atomic force microscope; the static contact angle value of deionized water on the surface of the intraocular lens detected by a static contact ...

Embodiment 2

[0046] A kind of preparation method of self-cleaning intraocular lens, its concrete steps are:

[0047] (1) Soak the hydrophobic acrylate intraocular lens in sterile double-distilled water for 5-10 minutes and ultrasonically clean it, and then dry it with N2 flow;

[0048] (2) The intraocular lens is fixed on the sample stage of the plasma cleaning machine, and O 2 The oxygen ion beam is formed to impact the surface of the intraocular lens to generate free radicals, the power is 60W, and the action time is 30s; the intraocular lens is placed in the chemical vapor deposition reaction chamber, and the PDMS stock solution is vaporized and sent into the reaction chamber under vacuum conditions. Heating to 100°C for 24 hours;

[0049] (3) After the reaction, the PDMS-modified intraocular lens was taken out and cooled to room temperature;

[0050] (4) The intraocular lens is sterilized with ethylene oxide and sealed for storage.

[0051] The intraocular lens prepared by this meth...

Embodiment 3

[0054] A kind of preparation method of self-cleaning intraocular lens, its concrete steps are:

[0055] (1) Soak the hydrophobic acrylate intraocular lens in sterile double-distilled water for 5-10 minutes and ultrasonically clean it, and then dry it with N2 flow;

[0056] (2) The intraocular lens is fixed on the sample stage of the plasma cleaning machine, and O 2 Form an oxygen ion beam to impact the surface of the intraocular lens to generate free radicals, the power is 60W, and the action time is 120s; then the intraocular lens is placed in the chemical vapor deposition reaction chamber, and the PDMS stock solution is vaporized and sent into the reaction chamber under vacuum conditions , heated to 100°C for 24 hours;

[0057] (3) After the reaction, the PDMS-modified intraocular lens was taken out and cooled to room temperature;

[0058] (4) The intraocular lens is sterilized with ethylene oxide and sealed for storage.

[0059] The intraocular lens prepared by this meth...

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Abstract

The invention belongs to the technical field of a medical intraocular lens, and particularly relates to a self-cleaning intraocular lens and a preparation method thereof. The preparation method comprises the specific steps of: (1) flushing the surface of an intraocular lens material with sterile double-distilled water, and blow-drying the surface of the intraocular lens material with nitrogen flow; (2) carrying out modification on the surface of the intraocular lens material by utilizing a plasma beam, and filling in O2 to form an oxygen ion beam to impact the surface of the intraocular lens to generate free radicals, so that a certain convex micro-nano structure is formed on the surface of the intraocular lens; (3) grafting the surface of the intraocular lens material, which is subjectedto plasma beam processing, with a PDMS (Polydimethylsiloxane) molecular chain by utilizing a chemical vapor deposition method; and (4) carrying out ethylene oxide sterilization packaging on the grafted self-cleaning intraocular lens. According to the preparation method of the intraocular lens, a coating based on self-cleaning ''similar liquid'' is formed on the surface; and according to the method, optical transparency of the intraocular lens can be kept for the post-cataract surgery, related complications such as posterior capsular opacity and the like can be prevented and treated, and guarantee can be provided for health of cataract patients.

Description

technical field [0001] The invention belongs to the technical field of medical intraocular lenses, in particular to a self-cleaning intraocular lens and a preparation method thereof. Background technique [0002] In the prior art, cataract is the main blinding disease in the world. With the aging of the global population, its incidence and the total number of patients are constantly increasing. Among the total 45 million blind people in the world, cataract blindness accounts for about 46%. %. At present, phacoemulsification is one of the main means of treating cataract diseases, and intraocular lens implantation is the most commonly used and most effective surgical method after cataract extraction. When the intraocular lens is implanted in the eye, the proteins and cells in the aqueous humor can adhere to its surface to activate the complement cascade reaction and promote the chemotaxis of neutrophils, and an intraocular inflammatory reaction occurs, which further produces ...

Claims

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Application Information

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IPC IPC(8): A61F2/16A61L27/34A61L27/50
CPCA61L27/34A61L27/50A61L2420/02A61F2/16015C08L83/04
Inventor 谢曦陈伟蓉刘冬吴倩妮
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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