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Efficient broad-spectrum antibacterial nano-emulsion and preparation method thereof

A high-efficiency broad-spectrum, nanoemulsion technology, applied in the field of antibacterial nanoemulsion, can solve the problems of peppermint oil being volatile, difficult to sterilize, and unable to obtain broad-spectrum antibacterial effect

Pending Publication Date: 2020-05-08
苏国霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Using colistin alone has a single effect and cannot obtain a more ideal broad-spectrum antibacterial effect, and colistin is difficult to dissolve in common solvents
On the other hand, peppermint oil is volatile and difficult to sterilize for a long time

Method used

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  • Efficient broad-spectrum antibacterial nano-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An antibacterial nanoemulsion, composed by weight: 5 parts of peppermint oil, 20 parts of nonionic surfactant (polyoxyethylene vegetable oil), 20 parts of cosurfactant (1,2-propylene glycol), 5 parts of colistin, oil (isopropyl myristate) 5 parts, water 50 parts.

[0026] The HLB value of the surfactant is 13-16; the mass ratio of the surfactant to the co-surfactant is 1 to 2:1; the mass ratio of the peppermint oil, oil, colistin to the surfactant Preferably, it is 1:0.5-1:0.5-2:1-4.

[0027] Its preparation method is as follows:

[0028] 1) Weigh the raw materials in the above ratio;

[0029] 2) Stir mint oil, colistin, polyoxyethylene vegetable oil, isopropyl myristate and ethanol at room temperature to obtain an oil phase solution;

[0030] 3) Under appropriate magnetic stirring conditions, add the water phase to the oil phase drop by drop to form colostrum, after ultrasonic cleaning for 10 minutes, centrifuge at 10000r / min for 10 minutes, and the supernatant is t...

Embodiment 2

[0032] Same as Example 1 except the amount of co-surfactant is 10 parts.

Embodiment 3

[0034] Same as Example 1, except the amount of oil is 2.5 parts.

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Abstract

The invention relates to a high-efficiency broad-spectrum antibacterial nano-emulsion. The nano-emulsion is characterized by comprising the following components in parts by weight: 1-10 parts of peppermint oil, 10-40 parts of a nonionic surfactant, 1-20 parts of a cosurfactant, 1-10 parts of colistin, 1-5 parts of oil and 20-50 parts of water. The HLB value of the surfactant is 13 to 16; the massratio of the surfactant to the cosurfactant is (1-2):1; and the mass ratio of the peppermint oil to the oil to the colistin to the surfactant is preferably 1:(0.5-1):(0.5-2):(1-4). The antibacterial nano-emulsion has a strong, broad-spectrum, natural and slow-release sterilization effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antibacterial nanoemulsion containing peppermint oil and colistin. Background technique [0002] Colistin, also known as colistin, colistin, polymyxin E (Polymyxin E), anti-enemy, etc., is an alkaline cyclic polypeptide (polypeptide) obtained from the culture medium of polymyxin bacteria. system) antibiotics, a mixture of polymyxins E1 and E2. It is white crystal or crystalline powder, slightly soluble in water, not easy to deliquescence. Its sulfate, colistin sulfate, is very stable and is a white powder, easily soluble in water, slightly soluble in methanol and ethanol, and insoluble in acetone and ether. It is more stable in the pH range of 3-7.5. Heat-resistant, difficult to absorb in the digestive tract, rapid excretion, low toxicity, no side effects, not easy to produce drug-resistant strains, but the antibacterial spectrum of colistin is narrow, mainly h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/44A61K47/10A61K36/534A61K38/12A61P31/02
CPCA61K9/1075A61K47/44A61K47/10A61K36/534A61K38/12A61P31/02A61K2300/00
Inventor 苏国霞
Owner 苏国霞
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