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Application of tricholoma matsutake extract

A kind of matsutake extract and technology of matsutake, which can be applied in the direction of drug combination, cosmetic preparations, skin care preparations, etc., and can solve the problems of enhancer reporting and so on

Inactive Publication Date: 2020-05-29
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, few enhancers with the effect of increasing G6PD expression have been reported in the literature

Method used

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  • Application of tricholoma matsutake extract
  • Application of tricholoma matsutake extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: extract matsutake extract

[0028] After crushing matsutake, weigh 50g powder and add 70% ethanol aqueous solution at a weight ratio of 1:10, extract by soaking and heating for 240 minutes at 20°C-60°C, collect the filtrate once after conventional filtration; pass through a 1-5μm filter membrane after cooling Filtrate to obtain a secondary filtrate; filter the secondary filtrate through a 0.1-0.65 μm filter membrane to obtain a third filtrate; concentrate and freeze-dry the third filtrate to obtain 3.68 g of matsutake extract freeze-dried powder.

Embodiment 2

[0029] Embodiment 2: G6PD enhancement test

[0030] Take matsutake extract 1.25g, add to 28.25g cream base (comprising following components by mass percentage: stearic acid 20.0%, potassium hydroxide (80%w / w) 1.25%, glycerin 10.0%, remove deionized water (68.75%), mix well, and prepare the cream of 4.2% w / w matsutake extract, take part of it, and use the cream base to prepare a paste with matsutake extract content of 0.42% w / w; 125 mg of vitamin C, added to 29.38 g of cream base, prepared into 0.42% w / w, for later use.

[0031] SPF grade Kunming mice, 24 females aged 6-7 weeks (Guangdong University of Traditional Chinese Medicine, 18-22g), 5 mice in a group, divided into normal group, UVB irradiation group, vitamin C group, matsutake extract high-dose protection group and Low-dose protection group of matsutake extract, 5 groups in total. The back skin of mice in each group was depilated, and the fluff was removed with 6% w / w sodium sulfide aqueous solution. The normal group ...

Embodiment 3

[0036] Embodiment 3: ROS scavenging test

[0037] Weigh 1.25g of matsutake extract, add 12.5mL glycerin and 12.5mL water, mix well, and prepare 4.2% w / w glycerol aqueous solution of matsutake extract, take part of the solution, and dilute to 0.42% w / w with glycerin aqueous solution, Then weigh 125 mg of vitamin C, add 12.5 mL of glycerin and 12.5 mL of water, mix well, and prepare 0.42% w / w for later use.

[0038] SPF grade Kunming mice, 25 females aged 6-7 weeks (Guangdong University of Traditional Chinese Medicine, 18-22g), 5 mice in a group, divided into normal group, UVB group, vitamin C group, matsutake extract high-dose protection group and matsutake Extract low-dose protection group, a total of 5 groups. The back skin of mice in each group was depilated, and the fluff was removed with 6% w / w sodium sulfide aqueous solution. The normal group only used glycerin aqueous solution to smear the back skin every day. Except the normal group, the rest of the groups were irradia...

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Abstract

The invention relates to the technical field of medicines and cosmetics, and discloses application of a tricholoma matsutake extract. The invention provides the application of the tricholoma matsutakeextract for improving the capacity of an endogenous antioxidant system in vivo, which can repair the damage of skin after photodamage / photoaging and treat diseases, tissue aging and tissue function reduction caused by G6PD deficiency, and can be applied to the preparation of G6PD enhancer or antioxidant.

Description

technical field [0001] The invention relates to the technical field of medicine and cosmetics, in particular to the application of matsutake extract. Background technique [0002] Glucose-6-phosphate dehydrogenase (G6PD) widely exists in animals and is distributed in the cytoplasm of all cells in the human body, including skin cells. G6PD is a key enzyme in the pentose phosphate pathway, which catalyzes the oxidation of 6-glucose phosphate to 6-phosphogluconolactone, and at the same time reduces NADP+ to NADPH for biosynthesis and maintenance of the reduced state in cells. Studies have shown that G6PD plays an important role in the process of oxidative stress. It will be activated and catalyzed to generate NADPH, which is mainly used in many biochemical reactions, such as reductive biosynthesis, glutathione reduction, detoxification and oxidase-mediated superoxide generation, etc., thereby maintaining the redox state in cells balance. Therefore, the level of glucose 6-pho...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P39/06A61P17/18A61K8/9728A61Q19/08A61Q19/00
CPCA61K36/07A61Q19/004A61Q19/08A61K8/9728A61P17/18A61P39/06
Inventor 邓黎丽太美灵
Owner INFINITUS (CHINA) CO LTD
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