4-chlorophenol molecular imprinting electrochemical sensor and preparation method thereof

A chlorophenol molecular and electrochemical technology, applied in the field of electrochemical sensing, can solve the problems of deep imprinted holes, affecting the mass transfer process, and complicated construction process of molecularly imprinted electrochemical sensors, etc., and achieves good electrical conductivity and Catalytic performance, the effect of sensitive and specific recognition

Active Publication Date: 2020-06-09
禾美思(山东)植物保护有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When preparing molecularly imprinted polymers by precipitation polymerization, it is often necessary to add cross-linking agents and initiators, but too much cross-linking agents and initiators will embed the imprinted holes too deeply, affecting the mass transfer process, which is not conducive to the target. The rapid response of the substance; the electropolymerization method is a method of directly forming a film on the electrode, and the preparation process is relatively simple, but it needs an electrical signal as the initiation and driving force to initiate the polymerization reaction
In addition, the molecularly imprinted polymers prepared by these two methods have poor conductivity. When combined with electrochemical sensors, in order to improve the detection sensitivity, it is necessary to introduce nanomaterials with better conductivity on the electrode surface, such as graphene. , carbon nanotubes, etc., making the construction process of molecularly imprinted electrochemical sensors cumbersome

Method used

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  • 4-chlorophenol molecular imprinting electrochemical sensor and preparation method thereof
  • 4-chlorophenol molecular imprinting electrochemical sensor and preparation method thereof
  • 4-chlorophenol molecular imprinting electrochemical sensor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Pass Al first 2 o 3 Polish the glassy carbon electrode with polishing powder (0.05 μm), then ultrasonically clean it in absolute ethanol and secondary water for 20 s, take it out and blow it dry with nitrogen, and then dry it with 1 mmol L -1 K 3 [Fe(CN) 6 ] and 0.1mol L -1 In the KCl solution, the cyclic voltammetry scan was carried out in the potential range of -0.2 ~ 0.6V until a stable redox peak appeared, that is, the polishing of the glassy carbon electrode was considered to be completed.

[0027] (2) 200ul, 0.13mol L -1 4-Chlorophenol was added to 20ml of Tris-HCl buffer solution with pH = 8.3, ultrasonically mixed evenly, then 20mg of dopamine hydrochloride was added, and reacted for 3 hours at room temperature under stirring conditions to obtain a molecularly imprinted polymer solution containing 4-chlorophenol ; 300ul, 0.023mol L -1 The cupric chloride solution was added to the above-mentioned molecularly imprinted polymer solution containing 4-chlo...

Embodiment 2

[0030] (1) The electrode polishing process is the same as in Example 1.

[0031] (2) 200ul, 0.13mol L -1 4-Chlorophenol was added to 20ml of Tris-HCl buffer solution with pH = 8.2, ultrasonically mixed evenly, then 15mg of dopamine hydrochloride was added, and reacted at room temperature for 3.3h under stirring conditions to obtain a molecularly imprinted polymer containing 4-chlorophenol Solution; 300ul, 0.02mol L -1 Add the copper chloride solution to the molecularly imprinted polymer solution containing 4-chlorophenol, and add 500ul, 0.02mol L dropwise while stirring. -1Sodium hypophosphite solution, stirred and reacted at 43°C for 1.7h, then heated up to 83°C at a rate of 3°C / min, continued to react for 27min, then centrifuged, washed, and 4-chlorophenol was removed with absolute ethanol to obtain Loaded with Cu@Cu 2 4-Chlorophenol molecularly imprinted polymers for O-composite nanoporous materials.

[0032] (3) The loaded Cu@Cu 2 The 4-chlorophenol molecularly impri...

Embodiment 3

[0034] (1) The electrode polishing process is the same as in Example 1.

[0035] (2) 200ul, 0.13mol L -1 4-Chlorophenol was added to 20ml of Tris-HCl buffer solution with pH = 8.4, ultrasonically mixed evenly, then 25mg of dopamine hydrochloride was added, and reacted at room temperature for 2.8h under stirring conditions to obtain a molecularly imprinted polymer containing 4-chlorophenol Solution; 300ul, 0.025mol L -1 Add the copper chloride solution to the molecularly imprinted polymer solution containing 4-chlorophenol, and add 500ul, 0.02mol L dropwise while stirring. -1 Sodium hypophosphite solution, stirred and reacted at 47°C for 1.3h, then heated up to 87°C at a rate of 2°C / min, continued to react for 23min, then centrifuged, washed, and 4-chlorophenol was removed with absolute ethanol to obtain Loaded with Cu@Cu 2 4-Chlorophenol molecularly imprinted polymers for O-composite nanoporous materials.

[0036] (3) The loaded Cu@Cu 2 The 4-chlorophenol molecularly imp...

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PUM

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Abstract

The invention relates to the technical field of electrochemical sensing, and discloses a 4-chlorophenol molecularly imprinting electrochemical sensor and a preparation method thereof. According to thepreparation method, 4-chlorophenol is taken as a template molecule, dopamine hydrochloride is taken as a functional monomer, and the 4-chlorophenol molecularly imprinted polymer loaded with the Cu@Cu2O composite nano porous material is prepared through adoption of a simple one-pot method. The 4-chlorophenol molecularly imprinted polymer loaded with the Cu@Cu2O composite nano porous material is combined with an electrochemical sensor in a dispensing manner to construct the 4-chlorophenol molecularly imprinted electrochemical sensor, and the sensor realizes rapid and sensitive specific recognition of 4-chlorophenol and can be used for detection of an actual water sample.

Description

technical field [0001] The invention relates to the technical field of electrochemical sensing, in particular to a 4-chlorophenol molecularly imprinted electrochemical sensor and a preparation method thereof. Background technique [0002] As one of the important raw materials in chemical production, 4-chlorophenol is widely used in the production and preparation of dyes, herbicides, and insecticides. However, 4-chlorophenol has high biological toxicity and refractory property, and the discharge of pollutants containing 4-chlorophenol into the environment without proper treatment will cause serious negative effects on the environment and human health. Therefore, it is of great significance to establish a simple and efficient detection method for the monitoring of 4-chlorophenol in the environment. The currently reported detection methods for 4-chlorophenol include immunoassay, capillary electrophoresis, chromatography, electrochemical analysis, and molecular imprinting elect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278Y02A50/30
Inventor 褚美洁
Owner 禾美思(山东)植物保护有限公司
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