Drug-loaded microspheres with synergistic sensitization effect of tumor radiotherapy and chemotherapy and preparation method thereof

Abstract

The invention provides a drug-loaded microsphere with a synergistic sensitization effect of tumor radiotherapy and chemotherapy and a preparation method thereof. The method includes: polyacrylic acid PAA and polyethylene glycol PEG aminated at both ends, under the action of the first activator, carry out amide reaction to obtain a block polymer of PAA‑PEG; the block polymer of PAA‑PEG Segment polymer and 1-hydroxyethyl-2-methyl-5-nitroimidazole MN, under the effect of the second activator, carry out esterification reaction, obtain MN-PAA-PEG polymer microsphere; Said MN ‑PAA‑PEG polymer and doxorubicin DOX are self-assembled to obtain doxorubicin-loaded DOX / MN‑PAA‑PEG microspheres, because the preparation method only needs to go through three steps of acylation reaction, esterification reaction and self-assembly The drug-loaded microspheres of the present application can be obtained in just one step, so the method has the characteristics of simple process, mild reaction conditions, and easy operation.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a drug-loaded microsphere with a synergistic sensitization effect of tumor radiotherapy and chemotherapy and a preparation method thereof. Background technique [0002] Cancer is one of the most lethal diseases in the world, and the global cancer incidence and mortality are increasing rapidly. According to the 2018 Global Cancer Annual Report, liver cancer is expected to become the sixth most common cancer and the fourth leading cause of cancer death worldwide in 2018. In 2018, there were 78,300 deaths from liver cancer worldwide, accounting for 8.2%. The mortality rate of liver cancer ranks fourth in the world and fifth in China. [0003] At present, the methods for clinical treatment of liver cancer mainly include surgical resection, radiotherapy and chemotherapy. Among them, systemic chemical drug therapy: For patients with advanced primary liver cancer, not only the p...

AI Technical Summary

Problems solved by technology

However, the drug-loaded nanoparticles still encounter many obstacles in the process of delivery to tumor cells, such as deep penetration into the tumor, drug transport, intracellular release, etc., resulting in a greatly limited anti-tumor effect of the drug. The effect of treatment often requires the injection of a large amount of drug-loaded nanoparticles, and the drug is released early and interacts with normal tissues before reaching the tumor tissue, resulting in premature drug failure

[0005] Therefore, the clinically used drugs for the treatment of liver cancer in related technologies still have problems such as large drug dosage, poor tissue compatibility, and failure of drugs due to early release.

Images