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Doxycycline hydrochloride-containing medicine for treating animal hysteritis and preparation method thereof

A technology of doxycycline hydrochloride and doxycycline, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve problems such as easy sticking, short duration of action, and poor therapeutic effect. To achieve long-lasting effect and good effect

Inactive Publication Date: 2020-07-10
河南官渡生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a large amount of manpower and material resources have been invested in prevention and treatment in various places, the incidence rate is still increasing, especially the long-term use of a large number of antibiotics and disinfectants, which has led to the enhancement of drug resistance of pathogenic bacteria, and because multiple excessive washings affect the recovery of uterine volume, so Clinically unsatisfactory therapeutic effects
[0005] Through above-mentioned analysis, the problem that prior art exists and defective are: (1) the medicine treatment effect of the treatment animal metritis containing doxycycline hydrochloride provided by prior art is poor, and the duration of action is short, easily rebounds in the healing effect
Moreover, the ebullient tablet medicine provided by the prior art is easy to swell the bag, and is easy to be sticky.
[0006] The difficulty in solving the above problems and defects is: Western medicine alone cannot guarantee a long-lasting curative effect, or the formula is unreasonable, or the way of medication is wrong

Method used

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  • Doxycycline hydrochloride-containing medicine for treating animal hysteritis and preparation method thereof
  • Doxycycline hydrochloride-containing medicine for treating animal hysteritis and preparation method thereof
  • Doxycycline hydrochloride-containing medicine for treating animal hysteritis and preparation method thereof

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preparation example Construction

[0046] Such as figure 1 Shown, the preparation method of the medicine that contains doxycycline hydrochloride treatment animal metritis provided by the invention comprises:

[0047] S101, drying the granulated acid-base granules in an oven at 60--65°C for 3-5 hours. Control the water content of the granules to 3-4%, and make 12 mesh whole granules.

[0048] S102, the acid-base granules are added together with the excipients magnesium stearate, borneol, and sodium starch glycolate and mixed with a two-dimensional mixer for 30 minutes, and the semi-finished product is determined to be qualified and then compressed into tablets.

Embodiment 1

[0051] The medicine containing doxycycline hydrochloride for treating animal metritis provided by the embodiments of the present invention consists of 2.4kg of doxycycline hydrochloride, 0.6kg of lactic acid TMP, 1.5kg of Houttuynia cordata extract, 0.6kg of Angelica sinensis extract, Patrinia extract 1.5kg, Astragalus polysaccharide 1.5kg, Scutellaria baicalensis extract 1.2kg, tartaric acid 10kg, sodium lauryl sulfate 1.2kg, lactose 8kg, corn starch 12kg, absolute ethanol 4kg, sodium bicarbonate mixture 22kg, hard Composition of magnesium fatty acid mixture 0.8kg and sodium starch glycolate 2.4kg.

Embodiment 2

[0053] The medicine containing doxycycline hydrochloride for the treatment of animal metritis provided by the embodiments of the present invention consists of 4 kg of doxycycline hydrochloride, 1.0 kg of lactic acid TMP, 2.5 kg of Houttuynia cordata extract, 1.0 kg of Angelica sinensis extract, Salmonella extract 2.5kg, astragalus polysaccharide 2.5kg, scutellaria baicalensis extract 2.0kg, tartaric acid 14kg, sodium lauryl sulfate 2.4kg, lactose 12kg, corn starch 20kg, absolute ethanol 4kg, sodium bicarbonate mixture 30kg, stearin Composition of 1.2kg of magnesium acid mixture and 2.4kg of sodium starch glycolate.

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Abstract

The invention belongs to the technical field of veterinary drugs, and discloses a doxycycline hydrochloride-containing medicine for treating animal hysteritis and a preparation method thereof. The doxycycline hydrochloride-containing medicine for treating animal hysteritis consists of the following components by mass: 3.2 kg of doxycycline hydrochloride, 0.8 kg of lactic acid TMP, 2kg of houttuynia cordata extract, 0.8 kg of an angelica sinensis extract, 2 kg of a dahurian patrinia herb extract, 2kg of astragalus polysaccharide, 1.6 kg of scutellaria baicalensis extract, 12kg of tartaric acid,2.4 kg of lauryl sodium sulfate, 10kg of lactose, 16kg of corn starch, 4kg of absolute ethyl alcohol, 24.15 kg of sodium bicarbonate mixture, 1.020 kg of a magnesium stearate mixture and 2.4 kg of carboxymethyl starch sodium. The medicine provided by the invention has a good effect on treating hysteritis of large animals such as pigs, cows and donkeys, has a lasting effect, and does not relapse after cure once. The prescription of the invention does not expand bags, and is not sticky in tabletting.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, in particular to a medicine containing doxycycline hydrochloride for treating metritis in animals and a preparation method thereof. Background technique [0002] At present, the metritis of cattle, pigs, donkeys and other domestic animals is mainly the inflammation of the endometrium, so it is also called endometritis. Uterine myositis, uterine serositis, may occur only in postpartum acute metritis, but rarely. Endometritis is common in cattle, which is usually inflammation or purulent inflammation of the uterine mucosa. It is the most common reproductive organ disease after childbirth and abortion. Metritis is secondary to pathogenic bacteria infection during dystocia, prolapse of the uterus, or retained placenta, or is infected by breeding. It is a common disease in dairy cows. In recent years, with the increase in dairy cow production and the expansion of the herd, the incidence ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/84A61P15/00A61P31/04A61K9/46A61K47/36A61K47/32A61K47/26A61K31/045A61K31/65A61K31/715
CPCA61K9/0007A61K9/2018A61K9/2027A61K9/2059A61K9/2095A61K31/045A61K31/65A61K31/715A61K36/232A61K36/236A61K36/533A61K36/539A61K36/78A61K36/84A61P15/00A61P31/04A61K2300/00
Inventor 隗存珠徐超军寨鸿瑞王亚丹董炎超闫虎峰
Owner 河南官渡生物工程有限公司
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