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A kind of multifunctional hemostatic sponge and its preparation method and application

A hemostatic sponge and multi-functional technology, applied in applications, medical formulas, bandages, etc., can solve the problems of increased pain and mortality of the injured, increased difficulty of wound treatment, increased difficulty of surgery, etc., to avoid secondary bleeding, Effect of improving hemostasis safety and rapid hemostasis performance

Active Publication Date: 2021-07-13
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Improperly worn materials can increase the difficulty of wound management and cause secondary trauma, resulting in significantly increased suffering and mortality for the injured
As for the hemostatic material, the spongy hemostatic dressing has its particularity, and auxiliary physical compression and postoperative dressing removal are often necessary, which brings challenges that need to be solved urgently: before the formation of a blood clot, a large number of Blood loss and adhesion of blood clots to the hemostatic dressing may lead to pain during subsequent procedures, secondary bleeding, and possibly even excipient residue during wound dressing removal, making surgery more difficult

Method used

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  • A kind of multifunctional hemostatic sponge and its preparation method and application
  • A kind of multifunctional hemostatic sponge and its preparation method and application
  • A kind of multifunctional hemostatic sponge and its preparation method and application

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Experimental program
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Embodiment approach

[0043]As mentioned above, there is an urgent need to prepare polymer materials for hemostasis that are safe, effective, environmentally friendly, and have high antibacterial properties. Based on this, the present inventors have conducted a lot of research on hemostatic polymer materials. The present inventors noticed that graphene oxide (GO), as a two-dimensional nano-carbon material, has the properties of hydrophilicity, electronegativity and easy modification. And GO nanosheets can activate Src kinase and release calcium ions from cells to trigger platelet aggregation and promote blood coagulation. The Chinese patent application number 201410262747.4 discloses a preparation method of a cross-linked graphene sponge and its application in trauma hemostasis, which is prepared by reacting graphene oxide with an amino cross-linking agent. The cross-linked graphene sponge has ultra-fast water absorption performance, can quickly enrich blood components, and achieve the effect of h...

Embodiment 1

[0082] (1) Preparation of methacryloyl chitosan MAC

[0083] Weigh 1.2g chitosan raw material (Mw=20000, the degree of deacetylation of chitosan is between 85%-99.9%) and dissolve it in 20mL of acetic acid solution (1%), add each chitosan repeatedly Unit 0.1 molar equivalent of methacrylic anhydride, and the mixture was reacted at room temperature for 1 hour under continuous shaking. The methacryloyl chitosan (DM=23%) was obtained by dialysis and freeze-drying.

[0084] (2) Preparation of cross-linked chitosan sponge CMS and multifunctional GO@CMS composite hemostatic sponge

[0085] Take the MAC prepared in step (1) and redissolve to obtain a 20mg / mL MAC solution, and then add graphene oxide solution, polyethylene glycol diacrylate (Mw=400) and MAC solution in a mass ratio of 4.5:2:1, It is guaranteed that graphene oxide accounts for 60% of the total system mass percentage. Add 1.5 mg / mL initiator to the system and react at 80°C for 2 hours to obtain a cross-linked product...

Embodiment 2

[0088] (1) Preparation of methacryloyl chitosan MAC

[0089] Weigh 1.2g chitosan raw material (Mw=50000, the degree of deacetylation of chitosan is between 85%-99.9%) and dissolve in 20mL of acetic acid solution (5%), add each chitosan repeatedly Unit 1 molar equivalent of methacrylic anhydride, the mixture was reacted at room temperature for 5 hours under continuous shaking. The methacryloyl chitosan (DM=35%) was obtained by dialysis and freeze-drying.

[0090] (2) Preparation of cross-linked chitosan sponge CMS and multifunctional GO@CMS composite hemostatic sponge

[0091] Take the MAC prepared in step (1) and redissolve to obtain a 30mg / mL MAC solution, and then add graphene oxide solution, polyethylene glycol diacrylate (Mw=800) and MAC solution in a mass ratio of 7:2:1, It is guaranteed that graphene oxide accounts for 70% of the total system mass percentage. Add 2mg / mL initiator to the system and react at 70°C for 4 hours to obtain a cross-linked product. After wash...

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Abstract

The invention relates to a multifunctional hemostatic sponge and its preparation method and application. The multi-functional hemostatic sponge is a compressible, portable, porous and multi-functional hemostatic sponge made from a composite solution of methacryloyl chitosan, polyethylene glycol diacrylate and graphene oxide through hydrothermal synthesis reaction and freeze-drying. sponge. The hemostatic sponge obtained by the invention has strong mechanical strength, fast liquid absorption capacity (<120ms) and certain antibacterial capacity, can rapidly enrich blood components, accelerate coagulation and inhibit microbial infection during treatment. The unique selective adhesion properties of the hemostatic sponge can seal the wound during emergency hemostasis to prevent blood loss and reduce the chance of secondary bleeding when removing materials. The sponge has the characteristics of good biocompatibility, non-toxicity, simple preparation, convenient portability, etc., and can be used in fields such as rapid hemostasis and wound healing of various wounds and cavities.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and relates to a multifunctional hemostatic sponge and its preparation method and application. Background technique [0002] Uncontrolled bleeding on the battlefield and during medical treatment can lead to serious complications such as hemorrhagic shock, microbial infection and multi-organ failure, even life-threatening. Improperly worn materials can increase the difficulty of wound management and cause secondary trauma, resulting in significantly increased suffering and mortality for the injured. As for the hemostatic material, the spongy hemostatic dressing has its particularity, and auxiliary physical compression and postoperative dressing removal are often necessary, which brings challenges that need to be solved urgently: before the formation of a blood clot, a large number of Blood loss and adhesion of blood clots to the hemostatic dressing may cause subsequent pain during th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/00A61L24/02A61L15/42A61L15/18A61L15/20A61L15/28A61L15/26A61L15/46C08B37/08C08F299/02
CPCA61L15/18A61L15/20A61L15/26A61L15/28A61L15/42A61L15/425A61L15/46A61L24/001A61L24/0015A61L24/0036A61L24/02A61L24/046A61L24/08A61L2300/108A61L2300/236A61L2300/406A61L2300/418A61L2400/04C08B37/003C08F299/026C08L5/08C08L71/02
Inventor 王兴徐聪聪
Owner BEIJING UNIV OF CHEM TECH