Preparation method of p-chlorophenylglycine
A technology of p-chlorophenylglycine and p-chlorobenzaldehyde is applied in the preparation of organic compounds, the preparation of cyanide reaction, chemical instruments and methods, etc. Low, avoids hazardous reagents, requires low-intensity effects on equipment
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0029] This embodiment provides a method for preparing p-chlorophenylglycine, which includes the following steps:
[0030] Step 1: Add the catalyst and p-chlorobenzaldehyde to the chloroform solution, and accelerate the dissolution of the catalyst and p-chloroformaldehyde in chloroform by shaking to make a mixed solution;
[0031] Step 2: Add the mixed solution made in step 1 to the sodium hydroxide solution and mix, and add liquid ammonia dropwise under stirring, and the time for the dropwise addition of liquid ammonia is 2h;
[0032] Step 3: After the dropwise addition of liquid ammonia is finished, add ammonium bicarbonate solution and react at room temperature for 8 hours;
[0033] Step 4. After the reaction, the reaction solution is concentrated by distillation and decolorization and filtration with activated carbon. The filtrate is adjusted to pH 6.0 with inorganic acid, and then cooled and filtered to obtain a crude product and mother liquor. The crude product is then subjected ...
Embodiment 2
[0039] This embodiment provides a method for preparing p-chlorophenylglycine, which includes the following steps:
[0040] Step 1: Add the catalyst and p-chlorobenzaldehyde to the chloroform solution, and accelerate the dissolution of the catalyst and p-chloroformaldehyde in chloroform by shaking to make a mixed solution;
[0041] Step two, add the mixed solution made in step one to the sodium hydroxide solution and mix, and add liquid ammonia dropwise under stirring, and the time for the dropwise addition of liquid ammonia is 4h;
[0042] Step 3: After the dropwise addition of liquid ammonia is finished, add ammonium bicarbonate solution and react at room temperature for 6 hours;
[0043] Step 4. After the reaction, the reaction solution is concentrated by distillation and decolorization and filtration with activated carbon. The filtrate is adjusted to pH 6.0 with inorganic acid, and then cooled and filtered to obtain a crude product and mother liquor. The crude product is then subjec...
Embodiment 3
[0049] This embodiment provides a method for preparing p-chlorophenylglycine, which includes the following steps:
[0050] Step 1: Add the catalyst and p-chlorobenzaldehyde to the chloroform solution, and accelerate the dissolution of the catalyst and p-chloroformaldehyde in chloroform by shaking to make a mixed solution;
[0051] Step two, add the mixed solution made in step one to the sodium hydroxide solution and mix, and add liquid ammonia dropwise under stirring, and the time for the dropwise addition of liquid ammonia is 4h;
[0052] Step 3: After the dropwise addition of liquid ammonia is completed, add ammonium bicarbonate solution and react at room temperature for 8 hours;
[0053] Step 4. After the reaction, the reaction solution is concentrated by distillation, and decolorized and filtered with activated carbon. The filtrate is adjusted to pH 6.0 with inorganic acid, and then cooled and filtered to obtain a crude product and mother liquor. The crude product is then subjected...
PUM
Property | Measurement | Unit |
---|---|---|
melting point | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com