Application of beta-glucan as adhesive in preparation of tablets or granules
A technology of glucan and granules, applied in the field of β-glucan tablets and its preparation, can solve the problems of poor compressibility, uneven mixing, inability to fully absorb, etc., to improve uniformity and consistency, prescription Simple composition, enhanced dissolution effect
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[0033] Example 1-3:
[0034]
[0035] Preparation:
[0036] 1) Disperse β-glucan in ethanol at a weight-to-volume ratio of 50% (w / v) and stir at 3500 rpm for 2 hours to form a β-glucan-ethanol mixture.
[0037] 2) Add the surfactant sodium lauryl sulfate to the above mixture, stir thoroughly, boil and dry at 70°C for 2 hours, determine the loss on drying to be 1.0%, and obtain β-glucan-sodium lauryl sulfate powder .
[0038] 3) Airflow pulverization of β-glucan-sodium lauryl sulfate powder to obtain β-glucan-sodium lauryl sulfate modified powder.
[0039] 4) The above-mentioned β-glucan-sodium lauryl sulfate modified powder is mixed with lactose, starch and croscarmellose sodium and then dry granulated,
[0040] 5) After mixing the above-mentioned particles and lubricant, the tableting speed is 20-60 rpm, and the tablet core hardness is 4-9kp.
Example Embodiment
[0041] Example 4-6:
[0042]
[0043] Preparation:
[0044] 1) Disperse β-glucan in acetone with a weight-volume ratio of 40% (w / v) and stir at 3500 rpm for 2 hours to form a β-glucan-acetone mixture.
[0045] 2) Add the surfactant sodium lauryl sulfate to the above mixture, stir thoroughly, boil and dry at 70°C for 2 hours, determine the loss on drying to be 1.0%, and obtain β-glucan-sodium lauryl sulfate powder .
[0046] 3) Airflow pulverization of β-glucan-sodium lauryl sulfate powder to obtain β-glucan-sodium lauryl sulfate modified powder.
[0047] 4) The above-mentioned β-glucan-sodium lauryl sulfate modified powder is mixed with lactose, crospovidone, and low-substituted hydroxypropyl cellulose, and then dry granulated.
[0048] 5) After mixing the above-mentioned particles and lubricant, the tableting speed is 20-60 rpm, and the tablet core hardness is 4-9kp.
Example Embodiment
[0049] Example 7-9:
[0050]
[0051]
[0052] Preparation:
[0053] 1) Disperse β-glucan in ethanol at a weight-to-volume ratio of 50% (w / v) and stir at 3500 rpm for 2 hours to form a β-glucan-ethanol mixture.
[0054] 2) Add the surfactant sodium lauryl sulfate to the above mixture, stir thoroughly, boil and dry at 70°C for 2 hours, determine the loss on drying to be 1.0%, and obtain β-glucan-sodium lauryl sulfate powder .
[0055] 3) Airflow pulverization of β-glucan-sodium lauryl sulfate powder to obtain β-glucan-sodium lauryl sulfate modified powder.
[0056] 4) The above-mentioned β-glucan-sodium lauryl sulfate modified powder is mixed with lactose, microcrystalline cellulose and croscarmellose sodium and then dry granulated,
[0057] 5) The above particles are mixed with magnesium stearate and compressed into tablets at a tableting speed of 20-60 rpm and a tablet core hardness of 4-9 kp.
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