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Application of beta-glucan as adhesive in preparation of tablets or granules

A technology of glucan and granules, applied in the field of β-glucan tablets and its preparation, can solve the problems of poor compressibility, uneven mixing, inability to fully absorb, etc., to improve uniformity and consistency, prescription Simple composition, enhanced dissolution effect

Active Publication Date: 2020-09-01
YICHUN WANSHEN PHARMA MACHINERY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, oat β-glucan is usually brewed with water and taken directly. This method prevents some active ingredients from being fully swollen, unable to exert the maximum efficacy of the drug, and cannot be fully absorbed after entering the body.
[0006] (2) The dispersibility of oat β-glucan is poor, resulting in uneven mixing with other excipients, poor compressibility, and the problem of uneven content in the subsequent preparation of granules or tableting

Method used

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  • Application of beta-glucan as adhesive in preparation of tablets or granules
  • Application of beta-glucan as adhesive in preparation of tablets or granules
  • Application of beta-glucan as adhesive in preparation of tablets or granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0034]

[0035] Preparation:

[0036] 1) Disperse β-glucan in ethanol with a weight to volume ratio of 50% (w / v), and stir at 3500rmp for 2 hours to form a β-glucan-ethanol mixture.

[0037] 2) Add the surfactant sodium lauryl sulfate to the above mixture, stir thoroughly, boil and dry at 70°C for 2 hours, measure the loss on drying to 1.0%, and obtain β-glucan-sodium lauryl sulfate powder .

[0038] 3) Jet milling the β-glucan-sodium dodecyl sulfate powder to obtain a modified powder of β-glucan-sodium dodecyl sulfate.

[0039] 4) dry granulate after mixing the above-mentioned β-glucan-sodium lauryl sulfate modified powder with lactose, starch, and cross-linked carmellose sodium,

[0040] 5) The above particles are mixed with a lubricant and then compressed into tablets, the tableting speed is 20-60rmp, and the tablet core hardness is 4-9kp.

Embodiment 4-6

[0042]

[0043] Preparation:

[0044] 1) Disperse β-glucan in acetone with a weight to volume ratio of 40% (w / v), and stir at 3500rmp for 2 hours to form a β-glucan-acetone mixture.

[0045] 2) Add the surfactant sodium lauryl sulfate to the above mixture, stir thoroughly, boil and dry at 70°C for 2 hours, measure the loss on drying to 1.0%, and obtain β-glucan-sodium lauryl sulfate powder .

[0046] 3) Jet milling the β-glucan-sodium dodecyl sulfate powder to obtain a modified powder of β-glucan-sodium dodecyl sulfate.

[0047] 4) Dry granulate the above-mentioned β-glucan-sodium lauryl sulfate modified powder with lactose, crospovidone and low-substituted hydroxypropyl cellulose,

[0048] 5) The above particles are mixed with a lubricant and then compressed into tablets, the tableting speed is 20-60rmp, and the tablet core hardness is 4-9kp.

Embodiment 7-9

[0050]

[0051]

[0052] Preparation:

[0053] 1) Disperse β-glucan in ethanol with a weight to volume ratio of 50% (w / v), and stir at 3500rmp for 2 hours to form a β-glucan-ethanol mixture.

[0054] 2) Add the surfactant sodium lauryl sulfate to the above mixture, stir thoroughly, boil and dry at 70°C for 2 hours, measure the loss on drying to 1.0%, and obtain β-glucan-sodium lauryl sulfate powder .

[0055] 3) Jet milling the β-glucan-sodium dodecyl sulfate powder to obtain a modified powder of β-glucan-sodium dodecyl sulfate.

[0056] 4) dry granulate after mixing the above-mentioned β-glucan-sodium lauryl sulfate modified powder with lactose, microcrystalline cellulose, and cross-linked carmellose sodium,

[0057] 5) The above particles are mixed with magnesium stearate and then compressed into tablets, the tablet compression speed is 20-60rmp, and the tablet core hardness is 4-9kp.

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Abstract

The invention relates to the field of pharmaceutical preparations, and provides an application of beta-glucan as an adhesive in the preparation of tablets or granules. Beta-glucan has certain viscosity, can play a certain role in adhesion in the tablet forming process, and can also ensure the dissolution of medicines. The invention further provides a pharmaceutical composition containing beta-glucan. Beta-glucan and a surfactant namely sodium dodecyl sulfate are jointly dispersed in an organic solvent, drying is carried out after sufficient stirring, airflow crushing is further carried out toobtain beta-glucan-sodium dodecyl sulfate modified powder, the dispersity of beta-glucan and the content uniformity of a preparation are effectively improved, and the medicine bioavailability is improved.

Description

Technical field: [0001] The invention relates to the field of pharmaceutical preparations, and relates to the application of beta-glucan as a binder in the preparation of tablets, in particular to a beta-glucan tablet and a preparation method thereof. Background technique: [0002] The β-(1→3, 1→4) glucan in oats is referred to as oat β-glucan, which is a short-chain glucan with a relatively small molecular weight, and the relative molecular weight varies from 5300 to 257200 , present in oat endosperm and aleurone cell wall. Its constituent monomers are β-D-glucopyranose, and the connection types are β-(1→3) and β-(1→4) glycosidic bonds. [0003] Oat β-glucan has a variety of therapeutic effects, such as anti-tumor, anti-oxidative stress, anti-tissue fibrosis, prevention and treatment of viral infection, prevention and treatment of pathogenic bacteria infection, prevention and treatment of neurodegenerative diseases, reduction of myocardial infarction or stroke or Risks ca...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/16A61K47/36A61K47/20
CPCA61K9/205A61K9/2013A61K9/1652A61K9/1617
Inventor 李琎杰熊洪峰杨春艳
Owner YICHUN WANSHEN PHARMA MACHINERY
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