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Antibacterial alginate dressing and preparation method thereof

A technology of alginate and antibacterial rate, which is applied in the field of biomedical materials, can solve the problems of difficulty in endowing biological materials with long-lasting antibacterial ability, lack of chemical activity, and weak combination, etc., achieve excellent hemostatic performance, increase microscopic roughness, and promote The effect of wound healing

Active Publication Date: 2020-09-15
JIANGYIN BENXIANG BIOTECHOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chitosan quaternary ammonium salt lacks chemically active reactive groups, and it is difficult to form a strong covalent bond with the biological material. At the same time, the chitosan quaternary ammonium salt added by physical blending is easy to migrate from the biological material. , loss, it is difficult to endow biomaterials with long-lasting antibacterial ability
[0008] Most of the current antibacterial alginate dressings are silver-loaded dressings, but the natural antibacterial materials with excellent biocompatibility limit their application due to the shortcomings of weak combination with materials.

Method used

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  • Antibacterial alginate dressing and preparation method thereof
  • Antibacterial alginate dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Preparation of aqueous ethanol solution: Weigh 40g of absolute ethanol and 60g of distilled water, and add them to a three-necked bottle.

[0049] 2. Preparation of ethanol aqueous solution of chitosan quaternary ammonium salt: weigh 1 g of chitosan, add it into a three-necked bottle, and stir evenly.

[0050] 3. Weigh 2g of calcium alginate dressing and add it to the plasma treatment apparatus;

[0051] 4. Set the processing power to 60W, pass in argon gas, take it out immediately after processing for 120 seconds, place it in a pre-configured 100 parts by weight of chitosan quaternary ammonium salt ethanol solution, shake it at 37°C for 60 minutes, pour off the reaction liquid.

[0052] 5. Add 200 parts by weight of ethanol solution with a mass fraction of 60%, wash for 60 minutes, and pour off the waste liquid.

[0053] Add 200 parts by weight of absolute ethanol, wash for 30 minutes, pour off the waste liquid, and freeze-dry to obtain the antibacterial calcium a...

Embodiment 2

[0055] 1. Preparation of aqueous ethanol solution: Weigh 60g of absolute ethanol and 40g of distilled water, and add them to a three-necked bottle.

[0056] 2. Preparation of ethanol aqueous solution of chitosan quaternary ammonium salt: weigh 2 g of chitosan, add it into a three-necked bottle, and stir evenly.

[0057] 3. Weigh 2g of sodium alginate dressing and add it to the plasma treatment apparatus;

[0058] 4. Set the processing power to 60W, feed in oxygen, take it out immediately after processing for 120 seconds, place it in the pre-configured 100 parts by weight of chitosan quaternary ammonium salt ethanol solution, shake at 37°C for 60 minutes, and pour out the reaction solution .

[0059] 5. Add 200 parts by weight of ethanol solution with a mass fraction of 60%, wash for 60 minutes, and pour off the waste liquid.

[0060] Add 200 parts by weight of absolute ethanol, wash for 30 minutes, pour off the waste liquid, and freeze-dry to obtain the antibacterial sodium ...

Embodiment 3

[0069] 1. Preparation of aqueous ethanol solution: Weigh 40g of absolute ethanol and 60g of distilled water, and add them to a three-necked bottle.

[0070] 2. Preparation of ethanol aqueous solution of chitosan quaternary ammonium salt: weigh 4 g of chitosan, add it into a three-necked bottle, and stir evenly.

[0071] 3. Weigh 2g of calcium alginate dressing and add it to the plasma treatment apparatus;

[0072] 4. Set the processing power to 90W, feed ammonia gas, take it out immediately after processing for 60 seconds, place it in the pre-configured 100 parts by weight of chitosan quaternary ammonium salt ethanol solution, shake at 37°C for 60 minutes, pour off the reaction liquid.

[0073] 5. Add 200 parts by weight of ethanol solution with a mass fraction of 40%, wash for 60 minutes, and pour off the waste liquid.

[0074] Add 200 parts by weight of absolute ethanol, wash for 30 minutes, pour off the waste liquid, and freeze-dry to obtain the antibacterial alginate dre...

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Abstract

The invention discloses an antibacterial alginate dressing and a preparation method thereof. The antibacterial alginate dressing is prepared by taking an alginate dressing as a raw material, performing plasma treatment and then performing soaking in a chitosan quaternary ammonium salt solution for graft modification, and carrying out a reaction for a period of time. Due to the fact that an adoptedantibacterial agent is a chitosan quaternary ammonium salt, the potential biological safety risks of silver ions and nano-silver in a traditional silver-containing alginic acid dressing are avoided.At the same time, the alginate dressing is pretreated by adopting the plasma treatment technology, so that no adverse effects are generated on the material itself. The obtained antibacterial alginatedressing has good moisturizing, hemostatic, antibacterial and bacteriostatic functions, is a multifunctional body surface dressing, and can be widely applied to the biomedicine field.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an antibacterial alginate dressing and a preparation method thereof. Background technique [0002] Microorganisms are present in all chronic wounds, including those without clinically apparent signs of infection. Wound contamination may involve the presence of low levels of microorganisms that are able to persist in the wound environment. In contrast, wound colonization involves the presence of multiplying bacteria, although an associated host response may not be observed. Sometimes, the presence of microorganisms (such as infection, etc.) in the wound is considered to be one of the important factors leading to delayed wound healing. [0003] Alginate dressing refers to a fibrous mesh dressing prepared from seaweed polysaccharides extracted from seaweeds through spinning, web forming and other processes. As a wound dressing, it can promote wound healing by maintaining the m...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/46A61L24/00A61L24/08
CPCA61L15/28A61L15/46A61L15/44A61L24/0015A61L24/08A61L2300/232A61L2300/404A61L2300/418A61L2400/04C08L5/08C08L5/04
Inventor 但年华余国飞但卫华丛亮亮
Owner JIANGYIN BENXIANG BIOTECHOLOGY
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