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Budesonide-loaded chitosan sponge

A technology of chitosan and sponge, which is applied in the field of chitosan sponge loaded with budesonide, can solve the problems of reducing drug efficacy and dependence on drug efficacy, and achieve the effect of promoting blood coagulation, preventing syneresis, and promoting wound healing

Inactive Publication Date: 2020-09-22
宁波旸曜医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most nasal spray medicines cannot stay in the nasal cavity and sinus mucosa for a long time due to the function of the nasal mucociliary transmission system, thereby reducing the efficacy of the medicine, and the efficacy of the medicine depends on the patient's compliance with the treatment.

Method used

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  • Budesonide-loaded chitosan sponge
  • Budesonide-loaded chitosan sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1 preparation and performance detection of budesonide-loaded chitosan sponge

[0044] 1. Preparation method

[0045] Dilute 1g of budesonide spray to 20mL with distilled water, add 1g of F127 and stir until dissolved, and configure solution A. Dissolve 10 g of chitosan in 400 mL of distilled water (1% acetic acid) to prepare solution B, then add 5 g of glycerol, 0.5 g of genipin, and solution A, and continue stirring for 60 minutes. The above solution was poured into a silica gel mold, and freeze-dried for storage.

[0046] 2. Scanning electron microscope observation

[0047] S-4800 (Hitachi, Japan) scanning electron microscope was used to observe the microstructure of chitosan hemostatic sponge. All samples were first fully dried at 60°C under vacuum conditions, and sprayed with gold before observation. It can be seen from electron microscope observation that the pore size distribution of the prepared chitosan porous sponge is uniform, about 200 μm. By ...

Embodiment 2

[0048] Embodiment 2 carries the clinical application of budesonide chitosan sponge

[0049] 1 Materials and methods

[0050] 1.1 Clinical data

[0051] This study adopts a double-blind, prospective experimental design, and takes CRS patients who received ESS from July 2019 to December 2019 in the Department of Otorhinolaryngology, Affiliated Hospital of Ningbo University School of Medicine as the research object. This research protocol has been approved and filed by the Ethics Committee of Ningbo University School of Medicine. All patients signed informed consent. The diagnostic criteria of CRS refer to the "Guidelines for the Diagnosis and Treatment of Chronic Rhinosinusitis in China (2018)". A total of 49 cases were included in this group of data, including 30 males and 19 females, aged 16-65 years.

[0052] 1.2 Treatment plan

[0053]All patients underwent sinus CT scan and nasal endoscopy before operation. One week before operation, oral antibiotics and budesonide nas...

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Abstract

The invention discloses a budesonide-loaded chitosan sponge. The prepared sponge is uniform in pore size distribution, and the pore size is about 200 microns. A porous material is prepared by combining a freeze drying technology and applying high-speed stirring of a surfactant and polysaccharide, so that the product is uniform in structure and high in porosity, the mechanical strength of the product is better enhanced, hemostasis acceleration is facilitated, and the budesonide anti-inflammatory effect can be degraded and slowly released during filling of an operation cavity.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a chitosan sponge loaded with budesonide. Background technique [0002] CRS is a clinical syndrome associated with persistent inflammation of the nasal mucosa and sinuses. Clinically, it can be divided into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without polyps (chronic sinusitis with nasal polyps). rhinosinusitis without nasal polyps, CRSsNP) two phenotypes. Endoscopic sinus surgery (ESS) is widely regarded as the standard approach for the treatment of CRS, but the success of ESS in patients with CRSwNP largely depends on the reduction of postoperative scarring, edema, and scabs, which would Inhibits natural ciliary function and sinus drainage. Post-endoscopic sinonasal adhesions, sinus stenosis, infection, and recurrence of inflammation complicate the treatment strategy for CRS, and drug-eluting stents, fillings, or implants are considere...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/20A61L15/26A61L15/42A61L15/44A61L15/46
CPCA61L15/20A61L15/26A61L15/28A61L15/425A61L15/44A61L15/46A61L2300/236A61L2300/404A61L2300/41A61L2300/412A61L2300/418A61L2300/43A61L2400/04C08L5/08C08L71/02
Inventor 徐明
Owner 宁波旸曜医疗科技有限公司
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