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Preparation method of bio-based medical auxiliary material

A bio-based, manufacturing method technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of low elongation at break, poor thermal stability, difficult processing, etc. Good sex, no inflammatory effect

Pending Publication Date: 2020-10-02
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of its biodegradability and biosynthesis, it is an environmentally friendly material that has been widely studied by the public. At present, more than 90 kinds of PHA with different structures and properties have been discovered. However, due to its high brittleness, low elongation at break, thermal Poor stability, difficult to process, has not been taken seriously

Method used

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  • Preparation method of bio-based medical auxiliary material
  • Preparation method of bio-based medical auxiliary material
  • Preparation method of bio-based medical auxiliary material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of the film is as follows: the polyester material is dissolved in chloroform at room temperature to obtain a 20wt% polyester-chloroform polymer mixture, and the mixture is stirred overnight on a magnetic stirrer to obtain a uniform and transparent high-molecular mixture. Molecular solution; place the polymer solution in the feeding syringe of the electrospinning equipment, and feed it at a feeding rate of 10 μl / min; adjust the distance between the needle tip of the syringe and the static grounding plate to 20 cm; adjust the spinning ambient temperature 30°C; turn on the high-voltage power supply and the feeding syringe pump, adjust the voltage to 20kV, adjust the air flow rate of the environment to 0-5m2 / min, cover the tin platinum paper on the static ground plate, and then obtain the electrospun fiber film, the film thickness 100-300μm.

[0026] Carefully remove the electrospun fiber film from the tinfoil, place it in a vacuum oven for annealing and dry...

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Abstract

The invention relates to a preparation method of a medical auxiliary material. The method comprises the following steps: by using polyhydroxybutyrate as a raw material and chloroform as a solvent, preparing the medical auxiliary material for surgical adhesion preventing film, artificial skin, artificial dura mater, absorbable surgical suture and the like under certain reaction conditions. The product has excellent histocompatibility with a human body, foreign matters causing inflammatory response do not exist, the auxiliary materials such as the film and the like prepared by the method are high in biological activity, the growth of epidermal tissues can be promoted, scar tissue hyperplasia can be reduced, and the anti-traction performance and flexibility of the film can meet the requirements of medical auxiliary materials. The medical fiber is long in degradation time and can be well used for manufacturing surgical sutures and medical auxiliary materials for treatment of wounds which are difficult to heal. The raw material used in the invention is a bio-based raw material, is a safe and environment-friendly green raw material, and has a wide production prospect.

Description

technical field [0001] The present invention relates to a manufacturing method of medical auxiliary materials, more specifically, the present invention relates to a manufacturing method of medical auxiliary materials such as films for preventing surgical adhesions, artificial skin, artificial dura mater, and absorbable surgical sutures. Background technique [0002] Medical dressings refer to protective coverings that cover wounds. Their functions are to help control hemostasis, protect wounds, reduce infection, absorb secretions, maintain body temperature, and promote wound healing. Wounds are prone to infection and difficult to heal. This is due to the fact that there is generally a warm and humid environment on the surface of the wound, and pathogens such as Staphylococcus aureus, Candida and Escherichia coli multiply quickly on the wound. Wounds can be seen everywhere in life, often causing damage to the skin and soft tissues. Once caused, it will bring a lot of inconven...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/50A61L27/58A61L27/60A61L31/06A61L31/14A61L17/10D04H1/435D04H1/728D04H3/011D04H3/02
CPCA61L27/18A61L27/60A61L27/50A61L27/58A61L31/06A61L31/14A61L31/148A61L17/105D04H1/728D04H3/02D04H3/011D04H1/435A61L2430/32C08L67/04
Inventor 李志波周现锋
Owner QINGDAO UNIV OF SCI & TECH
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