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Effect test
Embodiment 1
[0036] The preparation method of the polyetheretherketone bone repair material with antibacterial properties specifically includes the following steps:
[0037] Step 1: Ti 3 C 2 Preparation
[0038] First, add 1g of LiF (lithiumfluoride) to 20mL of 9mol / L hydrochloric acid solution and stir evenly, and then add 1g of Ti to the LiF / HCl solution 3 AlC 2 A mixture was obtained, and the mixture was stirred and reacted in an ice bath for 30 minutes and at a temperature of 35° C. for 24 hours, and then washed with deionized water to obtain Ti. 3 C 2 Tx suspension, will obtain Ti 3 C 2 Centrifuge the Tx suspension and wash it to a pH of 6 to obtain multilayer Ti 3 C 2 Tx. Ti to be obtained 3 C 2 Tx is re-dispersed in deionized water to obtain Ti 3 C 2 The dispersion liquid of Tx, then the dispersion liquid is placed in an ice bath and sonicated for 1 hour, and then the dispersion liquid after the ultrasonic treatment is centrifuged and the supernatant liquid is removed to obtain a monolay...
Embodiment 2
[0048] The polyether etherketone bone repair material with antibacterial properties was prepared according to the preparation method described in Example 1, except that:
[0049] In the step 1, the concentration of hydrochloric acid is 10mol / L, the mixture is stirred at 35°C for 48h, and the reaction time is 48h. 3 C 2 The Tx suspension is centrifuged and washed to a pH value of 5-6.
[0050] In the step 2, add N to the reaction solution 2 H 4 ·H 2 O, H 2 PtCl·6H 2 The amount of O is 650 μL and 300 μL, respectively.
[0051] In the step 3, Ti 3 C 2 The molarconcentration ratio of the suspension and the CoNWs suspension is 1:0.75, and the ultrasonic time of the mixed solution is 30 min.
[0052] In the step 4, the ultrasonic time of the polyetheretherketone substrate (PEEK) in concentrated sulfuric acid is 15 minutes.
[0053] In the step 5, the drying temperature of SPEEK after immersion is 55° C., and the number of cycles of immersion and drying is 4.
Embodiment 3
[0055] The polyether ether ketone bone repair material with antibacterial properties was prepared according to the preparation method described in Example 1, except that:
[0056] In the step 1, the concentration of hydrochloric acid is 9.5 mol / L, the mixture is stirred at 35°C for a reaction time of 36 hours, and Ti 3 C 2 The Tx suspension was centrifuged and washed to a pH of 5.5.
[0057] In the step 2, NaOH adjusts the pH value of the raw material liquid to 13, and adds N to the reaction liquid 2 H 4 ·H 2 O, H 2 PtCl·6H 2 The amount of O is 620 μL and 240 μL, respectively.
[0058] In the step 3, Ti 3 C 2 The molarconcentration ratio of the suspension and the CoNWs suspension is 1:1.
[0059] In the step 4, the ultrasonic time of the polyetheretherketone substrate (PEEK) in concentrated sulfuric acid is 15 minutes.
[0060] In the step 5, the drying temperature of SPEEK after dripping is 50° C., and the number of repeated dripping and drying cycles is 3.
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Abstract
The present invention discloses a polyether ether ketone bone repair material with antibacterial properties and a preparation method of the polyether ether ketone bone repair material. Cobalt nanowires and Ti<3>C<2> are compounded to delay combination of electrons and holes in Ti<3>C<2> energy bands and increase the transferred electrons to form singlet oxygen to solve a limiting problem of an antibacterial effect of the Ti<3>C<2>, thereby preventing SPEEK implants from infecting bacteria and inhibiting production of drug-resistant bacteria. In addition, polyether ether ketone is placed in concentrated sulfuric acid for sulfonation to obtain sulfonated polyether etherketone with rough and porous surface and sulfonic acid groups, which increases contact areas of a Ti<3>C<2>-CoNWs compositematerial and SPEEK and improving a binding force between the Ti<3>C<2>-CoNWs composite material and the SPEEK; and sulfonic acid groups on the surface of the SPEEK react with hydroxyl groups on the surface of the Ti<3>C<2> to form sulfonate, so that a chemical bond connection also exists between the SPEEK and Ti<3>C<2>-CoNWs composite material, so as to further strengthen the bonding force between the Ti<3>C<2>-CoNWs composite material and the SPEEK and avoid a problem of Ti<3>C<2>-CoNWs composite material falling off from the SPEEK during use.
Description
Technical field [0001] The invention relates to the field of biological materials, in particular to a polyetheretherketone bone repair material with antibacterial properties and a preparation method thereof. Background technique [0002] It is difficult to heal bone defects caused by various tumors, traumas, congenital deformities and other diseases. Therefore, how to improve bone defect healing is still a thorny problem faced by researchers and clinicians today. [0003] Special engineering plastic polyether etherketone (PEEK) has become the most promising hard tissue repair material that can replace traditional metal implants due to its excellent thermal stability, mechanical properties, radio permeability and biocompatibility. However, PEEK implantation surgery will inevitably encounter bacterial infections during the surgical process and postoperative recovery. In order to avoid bacterial infections, antibiotics are usually used to prevent bacterial infections and reduce the c...
Claims
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