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Oral bone regeneration and repair system and preparation method thereof

A repair system, bone regeneration technology, applied in tissue regeneration, additive manufacturing, manufacturing tools, etc., can solve the problems of insufficient soft tissue, lack of anti-infection ability, tissue healing, bacterial infection, etc.

Active Publication Date: 2020-10-13
苏州晶俊新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional absorbable collagen membrane or titanium membrane lacks certain anti-infection ability and the function of promoting tissue healing. Insufficient soft tissue and bacterial infection in the defect area often occur after bone augmentation surgery.
[0004] Therefore, in view of the problems of the above-mentioned barrier membranes, as well as the different forms of oral bone resorption damage, the disadvantages of long operation time for bone powder implantation, not easy to accumulate, complicated operation, and easy to cause infection, it is necessary to develop a new oral bone regeneration method. The repair system, which includes a barrier film that can meet the above requirements, and can achieve personalized customization, resist local bacterial growth in the oral cavity, quickly attract soft tissue healing, and promote in situ regeneration of bone tissue in bone defect areas

Method used

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  • Oral bone regeneration and repair system and preparation method thereof
  • Oral bone regeneration and repair system and preparation method thereof
  • Oral bone regeneration and repair system and preparation method thereof

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preparation example Construction

[0038] Such as figure 1 As shown, one aspect of the present invention provides a preparation method S100 of an oral bone regeneration repair system, which specifically includes the following steps S110-S140:

[0039] S110. Obtain three-dimensional shape data of the bone defect area of ​​the oral cavity to be repaired.

[0040] Specifically, combined with figure 2 As shown in Figure 1, cone beam computed tomography (CBCT) and intraoral optical scanning of the patient's oral cavity to be repaired were taken to obtain soft and hard tissue information in the defect area and the required image data of the lesion area (such as figure 2 a-2c), after that, using an image segmentation algorithm to separate the three-dimensional image data of the hard tissue, and reconstructing the three-dimensional image of the patient's oral bone defect through medical image processing software, and obtaining the three-dimensional shape data of the defect area after quantitative measurement, for ex...

Embodiment 1

[0062] This embodiment provides a preparation method of a composite oral regeneration restoration system. The specific preparation process includes the following steps:

[0063] S1. For patients with mild jaw fractures, perform full-mouth optical scanning, and based on the medical image data obtained by CBCT, use image segmentation algorithms to separate the three-dimensional image data of the defective jaw, and use Mimics Research21.0 medical image processing The software reconstructs the three-dimensional image of the jaw defect in the patient's mouth, and obtains the three-dimensional shape data of the jaw defect area after quantitative measurement.

[0064] S2. According to the three-dimensional morphological data of the jaw defect area, reconstruct the three-dimensional model of the bone bracket of the defective jaw, including the shape, size and position of the defect, and, on the basis of the three-dimensional model of the bone bracket in the jaw defect area, according t...

Embodiment 2

[0068] This embodiment provides a preparation method of a composite oral regeneration restoration system. The specific preparation process includes the following steps:

[0069] S1. For patients with mild alveolar osteonecrosis, perform full-mouth optical scanning, and based on the medical image data obtained by CBCT, use image segmentation algorithms to separate the three-dimensional image data of the defective alveolar bone, and use Mimics Research 21.0 medical The image processing software reconstructs the three-dimensional image of the alveolar bone defect in the patient's oral cavity, and obtains the three-dimensional shape data of the jaw defect area after quantitative measurement.

[0070] S2. According to the three-dimensional shape data of the jaw defect area, reconstruct the three-dimensional model of the bone scaffold of the defective bone, including the shape, size and position of the defect, and, on the basis of the three-dimensional model of the bone scaffold in t...

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Abstract

The invention provides an oral bone regeneration and repair system and a preparation method thereof, and belongs to the technical field of oral implantation. The preparation method comprises the following steps: acquiring three-dimensional morphological data of a bone defect area of an oral cavity to be repaired; separately establishing a barrier membrane three-dimensional model and a bone scaffold three-dimensional model according to the three-dimensional morphological data of the bone defect area; according to the barrier membrane three-dimensional model, forming a drug-loaded barrier membrane through printing, wherein the drug-loaded barrier membrane comprises a first arc-shaped surface and a second arc-shaped surface which are oppositely arranged in the thickness direction of the drug-loaded barrier membrane, and the first arc-shaped surface corresponds to the bone defect area of the oral cavity to be repaired; and according to the bone scaffold three-dimensional model, printing onthe first arc-shaped surface of the drug-loaded barrier membrane to form a drug-loaded porous bone scaffold so as to obtain the oral bone regeneration and repair system. According to the preparationmethod, the drug-loaded barrier membrane and the drug-loaded porous bone scaffold can be formed in batches by adopting a 3D printing technology, and the two-step forming method effectively avoids thermal decomposition of drugs with soft tissue healing promoting and antibacterial functions in the drug-loaded barrier membrane in the preparation process.

Description

technical field [0001] The invention belongs to the technical field of oral implantation, and in particular relates to a preparation method of an oral bone regeneration repair system and an oral bone regeneration repair system. Background technique [0002] Craniomaxillofacial bone is an important part of oral bone tissue. It not only serves as bony support, but also serves as the structural basis for mastication, swallowing and language. Various pathogenic factors such as tumors, trauma, osteoradionecrosis, osteomyelitis, periodontitis or congenital diseases can lead to bone defects and loss, and its incidence rate accounts for the first place in oral diseases. Severe craniomaxillofacial bone defects will further cause facial deformities and dysfunction, and at the same time increase the difficulty of subsequent oral restorative treatment, causing great physical and psychological pain to patients. Cranio-maxillofacial bone defect repair and reconstruction surgery is very d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61F2/30A61L27/54A61L27/56A61L27/58A61L27/50
CPCA61F2/28A61F2/30942A61L27/54A61L27/56A61L27/58A61L27/50A61F2/30771A61F2002/30948A61F2002/30985A61L2430/02A61L2300/404A61L2300/412A61F2002/30784
Inventor 白晶路萌萌王先丽程兆俊邵怡薛烽
Owner 苏州晶俊新材料科技有限公司
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