High-strength and high-antibacterial absorbable suture line

A kind of suture, high-strength technology, applied in the direction of conjugated synthetic polymer artificial filament, conjugated artificial filament, fiber chemical characteristics, etc., can solve the limitation of the use range of polyglycolic acid absorbable suture, incision redness, swelling, leakage Liquid and other problems, to achieve the effect of enhanced force, good biocompatibility, and firm knot

Inactive Publication Date: 2020-10-13
NEW MATERIAL INST OF SHANDONG ACADEMY OF SCI +1
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the strength of polyglycolic acid absorbable sutures is still not as strong as that of non-absorbable medical sutures, which limits the application range of polyglycolic acid absorbable sutures; at the same time, some patients will have rejection reactions to polyglycolic acid medical sutures, Cause incision redness, exudate, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High-strength and high-antibacterial absorbable suture line

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A high-strength and highly antibacterial absorbable suture is composed of the following components by mass: 90 parts of polyglycolic acid nanomaterials, 20 parts of chitosan, 4 parts of polyethylene glycol, 2.5 parts of cinnamon oil, and 2.5 parts of mannitol Wherein, the preparation method of polyglycolic acid nanomaterials is: (1) graphene oxide, polyethylene glycol and organic solvent are mixed homogeneously and ultrasonically dispersed to obtain graphene oxide dispersion liquid A, wherein graphene oxide kind is single-layer graphene oxide , the type of polyethylene glycol is polyethylene glycol 400, the organic solvent is acetone, the weight ratio of graphene oxide, polyethylene glycol and organic solvent is 0.02:2:50, the ultrasonic frequency is 49KHz, and the ultrasonic time is 3h; (2 ) adding the mixed solution A to the acetone solution of chloroacetic acid and stirring evenly to obtain the mixed solution B; (3) adding the acetone solution of triethylamine dropwis...

Embodiment 2

[0031] A high-strength and high-antibacterial absorbable suture is composed of the following components by mass: 80 parts of polyglycolic acid nanomaterials, 25 parts of chitosan, 3.5 parts of polyethylene glycol, 2 parts of cinnamon oil, and 2 parts of mannitol Wherein, the preparation method of polyglycolic acid nanomaterials is: (1) graphene oxide, polyethylene glycol and organic solvent are uniformly mixed and ultrasonically dispersed to obtain graphene oxide dispersion A, wherein the graphene oxide type is double-layer graphene oxide , the type of polyethylene glycol is polyethylene glycol 600, the organic solvent is methyl ethyl ketone, the weight ratio of graphene oxide, polyethylene glycol and organic solvent is 0.05:5:100, the ultrasonic frequency is 98KHz, and the ultrasonic time is 1.5h; ( 2) Add the mixed solution A to the methyl ethyl ketone solution of chloroacetic acid and stir evenly to obtain the mixed solution B; (3) Add the methyl ethyl ketone solution of tri...

Embodiment 3

[0036]A high-strength and highly antibacterial absorbable suture is composed of the following components by mass: 85 parts of polyglycolic acid nanomaterials, 25 parts of chitosan, 3.5 parts of polyethylene glycol, 2 parts of cinnamon oil, and 3 parts of mannitol Wherein, the preparation method of polyglycolic acid nanomaterials is: (1) graphene oxide, polyethylene glycol and organic solvent are mixed homogeneously and ultrasonically dispersed to obtain graphene oxide dispersion liquid A, wherein graphene oxide kind is three-layer graphene oxide , the type of polyethylene glycol is polyethylene glycol 1000, the organic solvent is acetonitrile, the weight ratio of graphene oxide, polyethylene glycol and organic solvent is 0.025:2.5:75, the ultrasonic frequency is 30KHz, and the ultrasonic time is 2.5h; ( 2) Add the mixed solution A to the methyl ethyl ketone solution of chloroacetic acid and stir evenly to obtain the mixed solution B; (3) Add the acetone solution of triethylamin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
glass transition temperatureaaaaaaaaaa
melting pointaaaaaaaaaa
strengthaaaaaaaaaa
Login to view more

Abstract

The invention relates to a high-strength and high-antibacterial absorbable suture line. The suture line is prepared from the following components in parts by mass: 80-100 parts of a polyglycolic acidnano material, 15-25 parts of chitosan, 3-5 parts of polyethylene glycol, 2-3 parts of cinnamon oil and 2-3 parts of mannitol. A preparation method of the polyglycolic acid nano material comprises thefollowing steps: uniformly mixing graphene oxide, polyethylene glycol and an organic solvent and carrying out ultrasonic dispersion to obtain a graphene oxide dispersion liquid A, adding the mixed solution A into an organic solvent of chloroacetic acid, performing uniform stirring to obtain a mixed solution B, dropwise adding an organic solvent of triethylamine into the mixed solution B at a lowtemperature, gradually performing heating until a reflux reaction is completed, performing concentrating to remove the solvent to obtain a mixture C, washing the mixture C with an alcohol compound toobtain a polyglycolic acid nano material crude product D, and carrying out forced air drying on the polyglycolic acid nano material crude product to obtain the polyglycolic acid nano material. The high-strength and high-antibacterial absorbable suture line prepared by the method disclosed by the invention has the advantages of high tensile strength, firm knotting, good biocompatibility, no adversereaction in a human body and lasting antibacterial performance.

Description

technical field [0001] The invention relates to a high-strength and high-antibacterial absorbable suture, which belongs to the technical field of polyglycolic acid nano-medical suture processing. Background technique [0002] Medical sutures are widely used in surgery and play an important role in promoting wound healing. The medical sutures used in the prior art can be divided into two categories, one is absorbable sutures and the other is non-absorbable sutures. For non-absorbable sutures, the process of removing them can be quite painful for the patient. Absorbable sutures have the obvious advantage of lessening the pain of stitch removal. After the patient's wound is healed, there is no need to remove the suture, and it can be left in the human body to absorb and degrade. However, absorbable sutures in the prior art have a high probability of allergic reactions in the human body, and some sutures require special antibacterial agents to be treated to achieve better ant...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/12A61L17/04A61L17/00D01F8/14D01F8/18D01F8/16D01F1/10
CPCA61L17/005A61L17/04A61L17/10A61L17/12A61L2400/12D01F1/10D01F8/14D01F8/16D01F8/18C08L5/08C08L71/02
Inventor 张硕张玉福石新华高宏宇王峰彭丹张方志牟秋红李金辉
Owner NEW MATERIAL INST OF SHANDONG ACADEMY OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap