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Water-soluble isoorientin-zinc complex as well as preparation method and application thereof

A technology of isoorientin and zinc complexes, which is applied to zinc organic compounds, pharmaceutical formulations, 2/12 groups of organic compounds without C-metal bonds, etc., can solve the problem of poor water solubility and insufficient physiological efficacy of isoorientin It can achieve the effect of good bacteriostatic effect, easy operation and good biosafety

Active Publication Date: 2020-10-30
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, isoorientin has poor water solubility and low bioavailability, which limits its physiological efficacy and its application in food and pharmaceutical industries.

Method used

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  • Water-soluble isoorientin-zinc complex as well as preparation method and application thereof
  • Water-soluble isoorientin-zinc complex as well as preparation method and application thereof
  • Water-soluble isoorientin-zinc complex as well as preparation method and application thereof

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preparation example Construction

[0033] A preparation method of water-soluble isoorientin-zinc complex, comprising the following steps:

[0034] 1) adding absolute ethanol to isoorientin, heating and dissolving in the dark, then adding zinc acetate, and adjusting the pH to 7.5-8.5 with NaOH-ethanol solution to obtain a mixed solution;

[0035] 2) The above-mentioned mixed solution is refluxed in a water bath, magnetically stirred, cooled, aged, precipitated and centrifuged to obtain a precipitate and a supernatant;

[0036] 3) The precipitate was washed with absolute ethanol and vacuum freeze-dried, and the obtained yellow solid powder was an isoorientin-zinc complex.

[0037] Further, in the step 1) the mass ratio of isorientin to zinc acetate is 2:3-4:6 (a range is best given), and the mass concentration of the NaOH-ethanol mixed solution is 2%.

[0038] Further, in the step 2), the temperature of the water bath is 50-65° C., and the stirring time is 6-10 hours.

[0039] An isorientin-zinc complex prepare...

Embodiment 1

[0046] A preparation method of water-soluble isoorientin-zinc complex, comprising the following steps:

[0047] 1) adding absolute ethanol to isoorientin, heating and dissolving in the dark, then adding zinc acetate, and adjusting the pH to 8 with NaOH-ethanol solution to obtain a mixed solution;

[0048] 2) The above-mentioned mixed solution is refluxed in a water bath, magnetically stirred, cooled, aged, precipitated and centrifuged to obtain the lower sediment and supernatant;

[0049] 3) The lower precipitate was washed with absolute ethanol, vacuum freeze-dried, and the obtained yellow solid powder was isoorientin-zinc complex.

[0050] In this embodiment, step 1) the mass ratio of isorientin to zinc acetate is 2:3, and the mass concentration of NaOH-ethanol mixed solution is 2%. The NaOH-ethanol mixed solution is that 2g of sodium hydroxide is dissolved in 98g of ethanol solution, and the mass concentration of the NaOH-ethanol mixed solution is 2%.

[0051] In this emb...

Embodiment 2

[0054] A preparation method of water-soluble isoorientin-zinc complex, comprising the following steps:

[0055] 1) adding absolute ethanol to isoorientin, heating and dissolving in the dark, then adding zinc acetate, and adjusting the pH to 8.5 with NaOH-ethanol solution to obtain a mixed solution;

[0056] 2) The above-mentioned mixed solution is refluxed in a water bath, magnetically stirred, cooled, aged, precipitated and centrifuged to obtain the lower sediment and supernatant;

[0057] 3) The lower precipitate was washed with absolute ethanol, vacuum freeze-dried, and the obtained yellow solid powder was isoorientin-zinc complex.

[0058] In this embodiment, step 1) the mass ratio of isorientin to zinc acetate is 3:4, and the mass concentration of NaOH-ethanol mixed solution is 2%. The NaOH-ethanol mixed solution is that 2g of sodium hydroxide is dissolved in 98g of ethanol solution, and the mass concentration of the NaOH-ethanol mixed solution is 2%.

[0059] In this e...

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Abstract

The invention belongs to the technical field of organic complex preparation, and relates to a water-soluble isoorientin-zinc complex and a preparation method and application thereof. The preparation method includes the steps: 1), adding absolute ethyl alcohol into isoorientin, then adding zinc acetate after isoorientin is dissolved, and adjusting the pH to 7.5-8.5 with a NaOH-ethyl alcohol mixed solution; 2) carrying out water bath reflux magnetic stirring, cooling, aging, and carrying out precipitation centrifugal separation to obtain a precipitate and a supernatant; 3) washing the precipitate with absolute ethyl alcohol, and carrying out vacuum freeze drying to obtain the isoorientin-zinc complex, wherein the water contact angle of the isoorientin-zinc complex is 17.4 degrees, and the isoorientin-zinc complex is applied to inhibition of escherichia coli and staphylococcus aureus. The isoorientin-zinc complex is good in water solubility and biological activity, good in biological safety and high in oxidation resistance, has a good inhibition effect on staphylococcus aureus and escherichia coli, and can be widely applied to the food and medicine industries.

Description

technical field [0001] The invention belongs to the technical field of organic complex preparation, and relates to a water-soluble isorientin-zinc complex and a preparation method and application thereof. Background technique [0002] Isorientin, a tetrahydroxyflavone compound, is also known as 3',4',5,7-tetrahydroxyflavone-6-O-β-D-glucopyranoside or luteolin 6- C-glucoside, the molecular formula is C21H2OO11, the molecular weight is 448.38, and its chemical structure is as follows figure 1 (a) shown. The solid isoorientin is a light yellow powder with a vapor density of 15.48 and a melting / freezing point of 237-239°C. It is a natural flavonoid that is slightly soluble in water and soluble in solvents such as ethanol and methanol. It is widely found in cucumber, buckwheat, passion fruit and other foods, and has the functions of anti-oxidation, anti-inflammation, antibacterial, liver protection, and regulation of intestinal flora. However, isoorientin has poor water solubi...

Claims

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Application Information

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IPC IPC(8): C07D407/04C07F3/06A61P31/04A61P39/06A61K31/555
CPCA61K31/555A61P31/04A61P39/06C07D407/04C07F3/003Y02A50/30
Inventor 袁莉何沈源李学毅
Owner SHAANXI NORMAL UNIV
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