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Hard tissue repair composition and hard tissue repair kit

A technology of hard tissue and composition, applied in the direction of tissue regeneration, application, drug delivery, etc., can solve the problems of tissue damage and fever in the affected part

Active Publication Date: 2020-10-30
MITSUI CHEM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such a composition generates a lot of heat during curing, and there is a high risk of causing damage to the affected tissue.

Method used

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  • Hard tissue repair composition and hard tissue repair kit
  • Hard tissue repair composition and hard tissue repair kit
  • Hard tissue repair composition and hard tissue repair kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6 and comparative example 1～3

[0223] In embodiment 1,3,4,6 and comparative example 1,3, use methyl methacrylate as monomer (A), use the partial tributyl boron oxide of 85 mass % and the ethanol mixture of 15 mass % ( Mitsui Chemicals Co., Ltd., model BC-S1i) (the total of the polymerization initiators (C) is 100% by mass) was used as the polymerization initiator (C), and barium sulfate (manufactured by Sakai Chemical Industry Co., Ltd.) was used as the contrast agent (X) .

[0224] In Examples 2, 5, and Comparative Example 2, a mixture of 99.5% by mass of methyl methacrylate and 0.5% by mass of reagent grade N,N-dimethyl-p-toluidine (manufactured by Wako Pure Chemical Industries, Ltd.) was used (The total of the monomers (A) is defined as 100 mass %) As the monomer (A), benzoyl peroxide (BPO) (manufactured by Aldrich, trade name Luperox (registered trademark) A75) was used as a polymerization initiator ( C) Barium sulfate (manufactured by Sakai Chemical Industry Co., Ltd.) was used as a contrast medium (X...

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Abstract

Disclosed is a hard tissue repair composition which comprises a monomer (A), a polymer powder (B), and a polymerization initiator (C), wherein the polymer powder (B) comprises a polymer powder (B-x) with an aspect ratio of at least 1.10; and among all of the powder particles in the components included in the hard tissue repair composition, the cumulative percentage of powder particles having an aspect ratio of 1.00 to less than 1.10 is at most 75 cumulative %. Also disclosed is a hard tissue repair kit having a member that divides the monomer (A), the polymer powder (B), and the polymerizationinitiator (C) included in the hard tissue repair composition into at least three in a given combination and stores the same.

Description

technical field [0001] The present invention relates to various characteristics required for compositions for hard tissue repair (for example, adhesiveness to adherends such as artificial joints, invasiveness to adherends such as cancellous bone, and reduction in the amount of eluted monomers) An excellent composition for hard tissue repair and a kit for hard tissue repair. Background technique [0002] Conventionally, as bone cements for fixing hard tissues such as bone and cartilage to artificial joints, or as bone fillers and artificial bone materials used in the treatment of osteoporosis, etc., for various hard tissues Repair compositions were studied. For example, compositions containing polymethyl methacrylate, methyl methacrylate, and benzoyl peroxide (polymerization initiator), inorganic fillers such as (meth)acrylate, calcium phosphate, and organic peroxide The composition of the compound has been studied (for example, Patent Document 1). However, such a composit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00A61L27/16A61L27/40A61L27/50
CPCA61L27/16A61L27/54A61L2300/404A61L2430/02A61L2400/06A61L24/06A61L2300/44A61L24/02C08L33/12A61L24/0015A61K31/7036A61K49/0404A61L24/001A61L2300/102A61L2300/232
Inventor 青木伸也杨晶晶中川亚弥后藤贤吾三浦高坂东绫子
Owner MITSUI CHEM INC