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Application of lamiophlomis rotata preparation in preparation of bortezomib synergist
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A bortezomib, a unique technology, applied in the field of pharmacokinetics, can solve problems such as adverse reactions that have not been investigated, and achieve the effects of improving in vivo exposure, relieving peripheral neuropathy, and improving blood drug concentration
Pending Publication Date: 2020-11-24
SHANGHAI CHANGZHENG HOSPITAL
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However, the effect of Duyiwei preparations on the exposure level of bortezomib in vivo and the adverse reactions of bortezomib-induced BIPN have not yet been investigated
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Embodiment 1
[0035] Example 1: The influence of unique preparation on the exposure level of bortezomib in vivo
[0036] 1.1 Experimental instruments and materials
[0037] Agilent 1290 ultra-high performance liquid chromatography connected in series with Agilent G6460 triple quadrupole tandem massspectrometer (Agilent, USA), BP110S one-hundred-thousandth balance (Sartorius, Germany), VX-200 vortex mixer (labnet, USA) , micro-volume adjustable pipette (Eppendorf, Germany), 5810R low-temperature high-speed centrifuge (Eppendorf, Germany), etc.
[0080] Example 2: Effect of Duyiwei preparation on adverse reactions of BIPN caused by bortezomib
[0081] 2.1 Instruments and reagents
[0082] Ceftriaxone for injection, trade name Rochefen, Shanghai Roche Pharmaceuticals; Duyiwei Capsules, Kangxian Duyiwei Biopharmaceutical Co., Ltd.; Sodium Glutamate Injection, Shanghai Xudong Haipu Pharmaceutical; Medical sterile water and normal saline, Shanghai Changzheng Hospital; sodium carboxymethylcellulose (CMC-Na, Sinopharm Chemical Reagent Co., Ltd.).
[0083] 2.2 Experimental method
[0084] Rocephine was prepared with NS to make 33.33mg / mL injection; the powder of Duyiwei preparation was suspended in 0.5% CMC-Na solution to make 12.5mg / mL suspension; sodium glutamate was diluted to 37.5 mg / mL with sterile water mg solution.
[0085] A total of 30 male SD rats with a body weight of 240-260 g were selected and randomly divided into 5 groups. The first group was the negative control group, which was injected with NS; the secon...
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Abstract
The invention relates to the field of pharmacokinetics, in particular to application of a lamiophlomis rotata preparation in preparation of a bortezomib synergist. The influence of the lamiophlomis rotata preparation on BIPN adverse reaction and in-vivo exposure level caused by bortezomib is investigated, and animal experiment results show that when the lamiophlomis rotata preparation and bortezomib are synchronously combined for application, the in-vivo metabolic process of bortezomib can be inhibited, the plasma concentration of bortezomib in vivo is remarkably increased, the in-vivo exposure level of the bortezomib is improved, the peripheral neuropathy (BIPN) caused by the bortezomib can be relieved, and a new research idea is provided for clinical bortezomib treatment.
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