Silk anticoagulation intravascular stent coating and preparation method thereof

A vascular stent and silk technology, which is applied in the field of silk anticoagulant tube stent coating and its preparation, can solve the problems of lack of histocompatibility and hemocompatibility of synthetic polymers, immune rejection, serious diseases, etc., and achieve excellent results. Biomechanical properties, effect of durable anticoagulant activity

Active Publication Date: 2020-12-08
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The lack of histocompatibility and blood compatibility of synthetic polymers is an important cause of postoperative complications. The inner surface of the film is difficult to endothelialize, and immune rejection will occur after a period of time in the body. Long-term medication will induce other diseases. occurrence of more serious disease

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0029] The invention provides a method for preparing a silk anticoagulant stent coating, comprising:

[0030] Step 1, preparing degummed silkworm silk fibers and cooked silk threads:

[0031] Select 40-160D (preferably 80D-120D) silk threads and silk monofilaments, the silk threads are obtained by twisting and merging silkworm raw silk, and put the silk monofilaments and silk threads at a bath ratio of 1:50 (g / mL) Boil in deionized water for 7 hours at a temperature of 98-100°C, and replace the deionized water several times during the boiling period until the deionized water fully removes the sericin contained in the silk monofilament and silk thread clean, and then place the silk monofilament and silk thread in an oven with a temperature of 60° C. to dry to obtain degummed silkworm silk fiber and cooked silk thread.

[0032] Step 2, preparing silkworm silk fibroin aqueous solution:

[0033] The degummed silkworm silk fibers were dissolved in 9.3M lithium bromide aqueous sol...

Embodiment 1

[0049] This implementation case shows a preparation method of silk anticoagulant stent covering, including:

[0050] 1. Twist silkworm raw silk and combine to obtain 80-120D silk thread group, and the other group is silk monofilament group. Put silk monofilament and silk thread into deionized water at a bath ratio of 1:50 (g / mL), and dissolve them at 98 Boiling at ~100°C for 7 hours, changing the deionized water several times during this period, then fully cleaning the silk with deionized water, and drying in an oven at 60°C to obtain degummed silkworm silk fibers and cooked silk threads.

[0051] 2. Weigh the degummed silkworm silk fiber and dissolve it in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treat at 65°C until the silkworm silk fiber is completely dissolved to obtain silkworm silk fibroin solution. The silkworm fibroin solution is poured into the dialysis bag. The wall of the dialysis bag is a semipermeable membrane with a molecular weig...

Embodiment 2

[0059] This implementation case shows a preparation method of silk anticoagulant stent covering, including:

[0060] 1. Twist silkworm raw silk and combine to obtain 80-120D silk thread group, and the other group is silk monofilament group. Put silk monofilament and silk thread into deionized water at a bath ratio of 1:50 (g / mL), and dissolve them at 98 Boiling at ~100°C for 7 hours, changing the deionized water several times during this period, then fully cleaning the silk with deionized water, and drying in an oven at 60°C to obtain degummed silkworm silk fibers and cooked silk threads.

[0061] 2. Weigh the degummed silkworm silk fiber and dissolve it in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treat at 65°C until the silkworm silk fiber is completely dissolved to obtain silkworm silk fibroin solution. The silkworm fibroin solution is poured into the dialysis bag. The wall of the dialysis bag is a semi-permeable membrane with a molecular wei...

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Abstract

The invention discloses a silk anticoagulation intravascular stent coating and a preparation method thereof. The preparation method comprises the following steps: dividing silkworm silk into two groups, twisting and combining one group of silkworm silk to obtain a silk thread group, taking the other group of silkworm silk as a monofilament group, and then boiling with deionized water for degumming, wherein the silk thread group is woven into a tubular structure by adopting a braiding machine, silk of the monofilament group is dissolved in a lithium bromide neutral salt solution to prepare a silk fibroin dissolving solution, then the silk fibroin dissolving solution is poured into a dialysis bag, the dialysis bag poured with the silk fibroin dissolving solution is placed in a container containing deionized water, and continuous dialysis is performed to obtain a silk fibroin solution; and the silk fibroin aqueous solution is concentrated by adopting a rotary evaporator, a proper amount of a cross-linking agent is added to react, the silk fibroin tubular braided fabric with the coating is impregnated layer by layer, and the coating anticoagulant drug hirudin is subjected to alternately or mixedly impregnating for multiple times to obtain the silk anticoagulant intravascular stent coating. The coating has excellent biomechanical properties and lasting anticoagulant activity.

Description

technical field [0001] The invention relates to the technical field of preparation of vascular stent coatings, in particular to a silk anticoagulant vascular stent coating and a preparation method thereof. Background technique [0002] With the improvement of living standards and the acceleration of the aging process, the incidence of cardiovascular and cerebrovascular diseases is increasing significantly year by year. Cardiovascular and cerebrovascular diseases such as embolism, vascular stenosis, and vascular aneurysm seriously threaten human health and have become human mortality. highest etiology. With the development of medicine, minimally invasive endovascular isolation has gradually become the main treatment method for various arterial lesions due to the small surgical trauma. Vascular covered stent is the main body of endoluminal isolation, and its performance directly affects the clinical treatment effect. However, complications such as slippage of vascular covered...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16A61L27/34A61L27/54A61L27/58A61L33/12C07K14/435C07K1/107
CPCA61L31/10A61L31/16A61L31/14A61L31/148A61L33/128A61L27/34A61L27/54A61L27/58C07K14/43586A61L2300/252A61L2300/42A61L2300/412A61L2300/606A61L2420/06A61L2420/08C08L89/00
Inventor 宋广州王建南裔洪根许建梅
Owner SUZHOU UNIV
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