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Gel for scrotum, gel patch as well as preparation method of gel and application of gel patch

A technology of gel and scrotum, which is applied in the field of medicine, can solve the problems of limited effect, poor effect, and low drug concentration, and achieve the effects of convenient and comfortable use, improved bioavailability, and good biocompatibility

Pending Publication Date: 2021-01-22
段有才
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After oral administration, after liver transformation and systemic metabolism, the local drug concentration in the testis is low, the effect is limited, and the effect is often not good

Method used

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  • Gel for scrotum, gel patch as well as preparation method of gel and application of gel patch
  • Gel for scrotum, gel patch as well as preparation method of gel and application of gel patch
  • Gel for scrotum, gel patch as well as preparation method of gel and application of gel patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment discloses the preparation method of the gel for scrotum of the present invention, and its raw material prescription is:

[0036] Hydroxymethylcellulose sodium 2g, L-carnitine 1000mg, zinc gluconate 70mg, triethanolamine 1.5g, propylene glycol 2.5mL, polyethylene glycol 50mL, polysorbate 800.5g, sodium sulfite 0.2g, ethylparaben 0.1g, Sodium glutamate 2g, add distilled water to make 100mL.

[0037] Preparation:

[0038] Take sodium hydroxymethyl cellulose and add appropriate amount of distilled water to stir, fully swell, and use it as matrix solution for later use;

[0039] Dissolve L-carnitine, zinc gluconate and polyethylene glycol to obtain a polyethylene glycol solution; add triethanolamine, propylene glycol, polysorbate 80, sodium sulfite, ethylparaben, and sodium glutamate to polyethylene glycol Mix evenly, and then add to the swollen sodium hydroxymethylcellulose matrix solution, mix evenly, and add distilled water to make 100mL.

Embodiment 2

[0041] This embodiment discloses the preparation method of the gel for scrotum of the present invention, and its raw material prescription is:

[0042] Xanthan gum 0.5g, L-carnitine 500mg, zinc gluconate 50mg, triethanolamine 1.5g, propylene glycol 15mL, polyethylene glycol 60mL, polysorbate 800.3g, sodium sulfite 0.2g, ethylparaben 0.1g, urea 3g, Add distilled water to make 100mL.

[0043] Preparation:

[0044] Take xanthan gum and add an appropriate amount of distilled water to stir, and after fully swelling, use it as a matrix solution for later use;

[0045] Take urea and add an appropriate amount of distilled water to dissolve it, and set aside;

[0046] Take L-carnitine, zinc gluconate and add polyethylene glycol to dissolve to obtain a polyethylene glycol solution; add triethanolamine, propylene glycol, polysorbate 80, sodium sulfite, and ethylparaben to polyethylene glycol and mix evenly, and then Then add it to the swollen xanthan gum matrix solution, add urea solu...

Embodiment 3

[0048] This embodiment discloses the preparation method of the gel for scrotum of the present invention, and its raw material prescription is:

[0049] Carboxymethylcellulose sodium 2g, L-carnitine 1500mg, zinc gluconate 100mg, triethanolamine 2g, propylene glycol 7mL, polyethylene glycol 30mL, polysorbate 800.8g, sodium sulfite 0.4g, ethylparaben 0.2g, oleic acid 2mL, add distilled water to make 100mL.

[0050] Preparation:

[0051] Take sodium carboxymethyl cellulose and add appropriate amount of distilled water to stir, fully swell, and use it as matrix solution for later use;

[0052] Dissolve L-carnitine, zinc gluconate and polyethylene glycol to obtain a polyethylene glycol solution; add triethanolamine, propylene glycol, polysorbate 80, sodium sulfite, ethylparaben, and oleic acid to the polyethylene glycol solution Mix evenly, and then add it into the swollen sodium carboxymethylcellulose matrix solution, mix evenly, and then add distilled water to make 100mL.

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Abstract

The invention discloses a gel for scrotum, a gel patch as well as a preparation method of the gel and an application of the gel patch. The problem of low bioavailability of oral medicines in the priorart can be solved. According to the gel for the scrotum, every 100 mL of the gel comprises 0.5-2 g of a gel matrix, 0.5-1.1 g of active ingredients, 3-8 mL of a penetration enhancer or 3-8 g of a penetration enhancer; and the active ingredients comprise the following substances of, in parts by weight, 500-1500 parts of L-carnitine and 50-100 parts of zinc gluconate. The gel patch for the scrotumcomprises a backing layer, a gel layer and a protective layer. The invention also discloses the application of the scrotum gel and the gel patch in preparation of drugs for treating oligospermia or / and asthenozoospermia. The gel and the gel patch are scientific in design and reasonable in formula, creatively treat oligospermia or / and asthenozoospermia in a gel external administration mode, effectively avoid the first-pass effect of the medicine, and improve the bioavailability.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a gel for the scrotum, a gel patch and a preparation method and application thereof. Background technique [0002] Oligospermia is a condition in which the number of sperm in the semen of a fertile man is lower than normal. The International Health Organization stipulates that the sperm per milliliter of a man should not be less than 15×10 9 / L, if lower than 15×10 9 / L is classified as oligospermia, which will have a great impact on fertility. Asthenospermia (asthenospermia) refers to a disease in which the forward moving sperm (grades a and b) in semen parameters are less than 32%. Asthenospermia is also called low sperm motility. In recent years, the incidence of male oligoasthenospermia has been increasing year by year. [0003] In the prior art, the treatment of male oligoasthenospermia is mainly through oral or intravenous supplementation of drugs, nutrien...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/70A61K47/38A61K47/10A61K47/18A61K31/205A61K31/315A61P15/00
CPCA61K9/0034A61K9/06A61K9/7023A61K31/205A61K31/315A61K47/10A61K47/18A61K47/38A61P15/00A61K2300/00
Inventor 段有才
Owner 段有才
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