Universal oral bandage and preparation method thereof

Abstract

The invention provides an oral bandage. The oral bandage comprises a fixing layer and an isolating layer which are sequentially attached, wherein the fixing layer comprises a hydrophobic surface and an adhesive surface, the hydrophobic surface is located on the outer side of the bandage, and the adhesive surface is located on the inner side; and a drug carrier is arranged on the isolating layer. The oral bandage can directly act on an ulcer affected part, can relieve pain, promote wound healing and shorten the disease course, has no side effects, is high in adhesive force, can firmly and durably act on the oral ulcer affected part, cannot fall off easily when a patient eats or drinks water, and reduces stimulation to the oral ulcer affected part when the patient eats or drinks water.

Description

Technical field[0001]The invention belongs to the technical field of medicine, and specifically relates to a universal oral bandage and a preparation method thereof.Background technique[0002]The oral cavity is the environment outside the teeth, and its main functions are saliva secretion and as a place to stay, chew and swallow food from outside. At the same time, there are microorganisms that live in symbiosis with the host in the oral cavity and form a tiny ecosystem with the oral environment. Under normal physiological conditions, the micro-ecosystem in the oral cavity is stable and can resist external influences on the environment. However, when there are oral mucosal lesions in the oral cavity, the invasion of the wound by external microorganisms can affect and slow down the healing of the lesion, and even aggravate the inflammation and deterioration of the wound, affecting daily life.[0003]Oral mucosal disease refers to a disease in which the normal color, appearance, integrit...

AI Technical Summary

Problems solved by technology

However, there are the following disadvantages: 1) low local drug concentration; 2) narrow drug selection: many dermatological drugs that are proven to be effective for oral mucosal diseases currently only have dosage forms that are suitable for oral or skin topical drug use; 3) systemic drug side effects are large

(1) The existing oral film is composed of hypromellose. This dosage form can temporarily adhere to the oral lesion, but it is water-soluble, easily dissolved by saliva and easily affected by oral movement. Strong, not long-lasting

(2) Although the existing oral patch can firmly adhere to the affected part of the oral cavity, after the patch absorbs water and swells, the foreign body in the oral cavity is obviously raised, which is easily affected by oral movement, drinking water and eating; in addition, the market The area of ​​the oral patch sold is small, and it cannot effectively protect large-area lesions

(3) Although the existing oral membrane glue can effectively protect the oral cavity wound surface, has a large area of ​​action, and can adapt to more complicated oral cavity wounds, it needs the assistance of ethanol solution during its use, and the ethanol solution of the oral membrane glue needs to be added during use. Adhering to the wound surface, it is easy to irritate the wound surface of the patient and reduce the adaptability of the patient

(4) The above preparations on the market are all developed for the single lesion of "oral ulcer". There is no therapeutic effect, and it does not really solve the problem of difficulty in local oral administration; and there are problems such as poor fixation, narrow selection of drugs, and inability to adjust the area of ​​action according to the wound surface.

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