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Joint implant with cartilage tissue formation promoting functional coating and preparation method of joint implant

A cartilage tissue and implant technology, applied in the field of medical supplies, can solve problems such as poor bonding of surrounding tissues, tissue wear, bone loss, etc., and achieve the effect of improving coating strength and promoting spreading

Active Publication Date: 2021-03-12
广东广纳安疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are two methods of implantation and repair of joint injuries: 1. Autogenous bone marrow stimulates proliferation and differentiation and direct transplantation of autologous bone tissue. This method will cause secondary damage to the patient, and bone tissue deactivation and infection are also faced during the transplantation process. At the same time, due to the limited source of autologous bone, the cost of proliferation and differentiation culture is very high; 2. Biomaterials such as metal (titanium alloy) and ceramics (hydroxyapatite) are used for replacement, but conventional metals, ceramic materials and human tissue In the process of direct contact, due to the mismatch of elastic modulus, it will have poor bonding force with the surrounding tissue, which may cause tissue wear at the implant site, resulting in bone loss and bone wear, and these implants can only replace part of the function of the hard bone. It cannot replace the function of cartilage, nor can it induce the growth of chondrocytes and promote the formation of cartilage tissue

Method used

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  • Joint implant with cartilage tissue formation promoting functional coating and preparation method of joint implant
  • Joint implant with cartilage tissue formation promoting functional coating and preparation method of joint implant
  • Joint implant with cartilage tissue formation promoting functional coating and preparation method of joint implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for preparing a joint implant with a cartilage tissue-promoting functional coating, which comprises the following steps: immersing the base of the joint implant made of titanium in a silane coupling agent for 3 hours, taking it out, drying it, and then The coating solution that will be dissolved with functional coating (pure water is made solvent, and functional coating concentration is 5wt% in the coating solution, and the mass ratio of functional coating and photoinitiator in the coating solution is 1000:2, and photoinitiator can be Irgacure2959) was evenly spread on the surface of the modified joint implant matrix, and after the functional solution was cured under ultraviolet light to form a functional coating, New Zealand white rabbit chondrocytes were co-cultured with the joint implant matrix to form a functional coating. Cartilage tissue is grown in the medium, that is, a joint implant with a coating that promotes the formation of cartilage tissue is obtai...

Embodiment 2

[0039]A method for preparing a joint implant with a cartilage tissue-promoting functional coating, the preparation comprising the following steps: immersing the base of the joint implant made of ceramics in a silane coupling agent for 4 hours, taking it out, drying it, and then The coating solution that will be dissolved with functional coating (pure water is made solvent, and functional coating concentration is 7wt% in the coating solution, and the mass ratio of functional coating and photoinitiator in the coating solution is 1000:3, and photoinitiator can be Irgacure2959) was evenly applied on the surface of the modified joint implant matrix, and after the functional solution was cured under ultraviolet light to form a functional coating, the chondrocytes (patient-derived chondrocytes were used in practical applications) and the joint implant matrix were collected. Carrying out co-cultivation to grow cartilage tissue in the functional coating, that is, to obtain a joint impla...

Embodiment 3

[0042] A method for preparing a joint implant with a cartilage tissue-promoting functional coating, which comprises the following steps: immersing a joint implant matrix made of titanium alloy in a silane coupling agent for 5 hours, taking it out, drying it, and then Then the coating solution (water for injection) that is dissolved with functional coating is made solvent, and functional coating concentration is 10wt% in the coating solution, and the mass ratio of functional coating and photoinitiator is 1000:4 in the coating solution, and photoinitiator can be Irgacure2959) was evenly applied on the surface of the modified joint implant matrix, and after the functional solution was cured under ultraviolet light to form a functional coating, rat bone marrow rechargeable stem cells were co-cultured with the joint implant matrix (co-cultivation process Inducing stem cells to differentiate to form chondrocytes) to grow in the functional coating to obtain cartilage tissue, that is, ...

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PUM

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Abstract

The invention relates to a joint implant with a cartilage tissue formation promoting functional coating and a preparation method thereof. The preparation method comprises the following steps that a joint implant matrix is subjected to surface modification treatment, and then the surface of the modified joint implant matrix is evenly coated with a coating solution dissolved with a functional coating; after the functional solution is cured to form a functional coating, mature cartilage tissue or stem cells capable of being differentiated into cartilage cells are taken to be co-cultured with thejoint implant matrix, so that the cartilage tissue grows in the functional coating, and the joint implant with the function coating for promoting the cartilage tissue to form is obtained. Experimentsshow that a stable cartilage tissue block can be formed within one week after the joint implant with the formed functional coating and rabbit cartilage cells are co-cultured and then implanted into aNew Zealand white rabbit hind limb tibia knee joint injury model, a stable cartilage tissue block can be formed within one week, and the implanted joint implant can enable the cartilage cells to rapidly proliferate to generate secreta; therefore, an extracellular matrix which can wrap cartilage cells and provide a place for anaerobic glycolysis of the cartilage cells is formed.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a joint implant with a cartilage tissue-promoting functional coating and a preparation method thereof. Background technique [0002] The joint structure is composed of hard bone, articular cartilage, joint capsule, joint synovium, and joint synovial fluid. Therefore, the joint structure has the characteristics of no nerve tissue, no blood vessel distribution, and no lymphatic tissue. For self-repair, only artificial implants (including autologous grafts and artificially synthesized foreign substances) can be used for intervention and repair. [0003] At present, there are two methods of implantation and repair of joint injuries: 1. Autogenous bone marrow stimulates proliferation and differentiation and direct transplantation of autologous bone tissue. This method will cause secondary damage to the patient, and the transplantation process also faces bone tissue deactivati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/30A61L27/06A61L27/10A61L27/34A61L27/38A61L27/50A61F2/32A61F2/42A61F2/40A61F2/38
CPCA61F2/30767A61F2/30942A61L27/06A61L27/10A61L27/34A61L27/3817A61L27/3834A61L27/50A61F2/32A61F2/4202A61F2/4261A61F2/40A61F2/3804A61L2420/02A61L2430/24A61L2430/06C08L5/08
Inventor 何佳鹏李涵刘宏孙海霞袁冰寒李青凯李妍刘爽顾静飞唐骆沈礼峰
Owner 广东广纳安疗科技有限公司