Degradable medical elastomer material and application thereof
A technology of elastomer material and composite material, used in stent for pancreatic duct drainage, degradable elastomer material and its application in the fields of ureter, bile duct, and biomedical materials, which can solve the limitation, the degradation speed of the elastomer is fast, and the drainage time cannot be reached. and other problems to achieve the effect of ensuring no breakage, reliable fixing effect and stable size
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[0044] Example 1 Preparation of L-lactide / ε-caprolactone copolymer
[0045] 500 g of crystalline purification treatment of L-lactide (LLA) and vacuum dehydration purification treatment was placed in a 5000 ml reactor, and 0.015% tin catalyst was added. The polymerization of nitrogen and 150 ° C was concentrated for 24 hours to obtain a L-lactide / ε-caprolactone copolymer. The copolymer was dissolved in dichloromethane, precipitated with ethanol, and the precipitate was dried in a vacuum dryer at 60 ° C for 48 hours to obtain L-lactide / ε-caprolactone copolymer 1 (PLC1). The product was filled with 0.1% by weight of the concentration of chloroform solution, and the viscosity of its characteristic was tested at 30 ° C with a ubus viscometer; the deuterated chloroform is a solvent, using a nuclear magnetic 1 H spectrum was measured in which the ratio of L-lactide and ε-caprolactone segment; with a hot press molding method, on the flat vulcanizer, 140 ° C-170 ° C, the above materi...
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[0050] Example 2 Preparation of a glycoside / ε-caprolactone copolymer
[0051] 540 g of a crystalline purified azimide (Ga) and a vacuum dehydrated purification treatment 480 g ε-caprolactone monomer (CL) were placed in a 3000 ml reactor, and 0.02% octoate catalyst was added. Under nitrogen protection, the system temperature was raised to 150 ° C, and the reaction was 1 hour, and the temperature was raised to 180 ° C for 12 hours, and the polymer was transferred out of the reactor, further pulverized into particles of less than 3 mm, and put it in 90 The unreacted monomer was removed in a vacuum oven in a vacuum oven at ° C to give a hydrazine / ε-caprolactone copolymer 1 (PGC1). The product was filled with 0.1% by weight of hexafluoropropyl alcohol solution, and the viscosity of its characteristic was tested at 30 ° C with a ubus viscometer; the hexafluoropropyl alcohol is a solvent, using a nuclear magnetic 1 H spectrum was measured in which a proportion of hydraulic and ε-capr...
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[0056] Example 3 Preparation of L-lactide / ε-caprolactone copolymer and a hydrazine / ε-caprolactone copolymer composite (PLC / PGC)
[0057] 300 g of the above L-lactide / ε-caprolactone copolymer 1 (PLC1) and 100 g of a hydrazine / ε-caprolactone copolymer (PGC1) were dissolved in the dichloromethane solution, and mixed mixed well after stirring Further, the blended polymer solution was mixed with the precipitant ethanol, and the precipitated polymer was washed, and the PLC / PGC composite 1 of the present invention was obtained in vacuo to dryness at 60 ° C for 48 hours. The above material is made of a dumbbell piece on a flat plate vulcanizing machine with a hot pressing method, 140 ° C-170 ° C. According to Example 1, the tensile strength of the composite is tested, the elongation at break, the Shaw's hardness a value and the intensity maintenance time are tested. The preparation of PLC / PGC composites can also be achieved in the following method.
[0058] The L-lactide / ε...
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