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Production process of ethyl m-aminobenzoate

A kind of technology of ethyl aminobenzoate and production process, applied in the field of production technology of ethyl m-aminobenzoate, can solve problems such as equipment corrosion, low catalytic efficiency, unfavorable human health and the like

Inactive Publication Date: 2021-04-20
HANGZHOU JUNLING PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process route is relatively complicated, using concentrated hydrochloric acid as the catalyst, the catalytic efficiency is low and the equipment is easily corroded
Furthermore, this process route will produce a large amount of waste acid and hydrogen chloride gas, and hydrogen chloride gas has a pungent smell, which is not conducive to human health

Method used

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  • Production process of ethyl m-aminobenzoate
  • Production process of ethyl m-aminobenzoate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of production technique of ethyl m-aminobenzoate, comprises the steps:

[0028] Pre-treatment: After nitrogen gas is introduced to remove the air in the trickle bed reactor, carbon monoxide is passed into the trickle bed reactor, and the catalyst DCyPP·Pd(OAc)2 and potassium carbonate are mixed evenly and then loaded into the trickle bed reactor In; 3-chloroaniline and ethanol are mixed to obtain reaction raw material mixture A; wherein, by mass ratio 3-chloroaniline: ethanol: catalyst DCyPP Pd (OAc) 2 : potassium carbonate=13:20:1.0:28;

[0029] Continuous production: Add the reaction raw material mixture A into the trickle bed reactor, feed carbon monoxide, keep the pressure in the reactor at 0.2MPa, and react at 90°C for 1.5h; after the reaction, the mixture B is obtained;

[0030] Purification: pump the mixture B into the rectification tower, control the temperature of the distillation tower at 120°C, cool the low boiling point compound through the condenser...

Embodiment 2

[0032] A kind of production technique of ethyl m-aminobenzoate, comprises the steps:

[0033] Pre-treatment: After passing nitrogen to remove the air in the trickle bed reactor, carbon monoxide is passed into the trickle bed reactor, and the catalyst DCyPP·Pd(OAc) 2 Mix evenly with potassium carbonate and put it in a trickle bed reactor; mix 3-chloroaniline and ethanol to obtain reaction raw material mixture A; wherein, by mass ratio 3-chloroaniline: ethanol: catalyst DCyPP Pd(OAc) 2 : potassium carbonate=13:18:0.7:26.

[0034] Continuous production: Add the reaction raw material mixture A into the trickle bed reactor, feed carbon monoxide, keep the pressure in the reactor at 0.15MPa, and react at 90°C for 1.5h; after the reaction, the mixture B is obtained;

[0035] Purification: pump the mixture B into the rectification tower, control the temperature of the distillation tower at 120°C, cool the low boiling point compound through the condenser to obtain distillate C, and mea...

Embodiment 3

[0037] A kind of production technique of ethyl m-aminobenzoate, comprises the steps:

[0038] Pre-treatment: After passing nitrogen to remove the air in the trickle bed reactor, carbon monoxide is passed into the trickle bed reactor, and the catalyst DCyPP·Pd(OAc) 2 Mix evenly with potassium carbonate and put it in a trickle bed reactor; mix 3-chloroaniline and ethanol to obtain reaction raw material mixture A; wherein, by mass ratio 3-chloroaniline: ethanol: catalyst DCyPP Pd(OAc) 2 : potassium carbonate=13:18:0.6:26.

[0039] Continuous production: Add the reaction raw material mixture A into the trickle bed reactor according to the preset ratio, feed carbon monoxide, keep the pressure in the reactor at 0.12MPa, and react at 100°C for 1 hour; after the reaction, the mixture B is obtained;

[0040] Purification: pump the mixture B into the rectification tower, control the temperature of the rectification tower tank at 120°C, cool the low boiling point compound through the co...

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Abstract

The invention provides a production process of ethyl m-aminobenzoate, and the production process comprises the following steps: filling a trickle bed reactor with a catalyst DCyPP.Pd(OAc)2 and potassium carbonate, adding a mixture of 3-chloroaniline and ethanol, introducing carbon monoxide, keeping the pressure in the reactor at 0.1-0.2 MPa, carrying out carbonylation esterification reaction, and performing purifying by a rectifying tower to obtain the ethyl m-aminobenzoate with the molar yield of 97%, wherein the purity of the ethyl m-aminobenzoate is more than 98.5%. According to the method, ethyl m-aminobenzoate can be continuously produced, reaction raw materials are convenient and easy to obtain, the process is simple, reaction conditions are mild, reaction energy consumption is low, no waste acid is generated in the reaction process, and the method is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a production process of ethyl m-aminobenzoate. Background technique [0002] In recent years, with the development and progress of new energy chemical technologies such as coal chemical industry, shale gas chemical industry, and biomass chemical industry, the development of carbon-one (C1) chemical technology that replaces traditional petrochemical process routes to prepare organic basic chemical raw materials and fuels has received a lot of attention. The high attention of academia and industry has become an important research direction of energy chemistry and green chemistry. C1 resources have the characteristics of a wide range of sources, generally from carbon-containing resources such as petroleum, coal, natural gas, and biomass. In addition, CO is a cheap C1 resource, and its resource utilization is also of great practical significance. At present, th...

Claims

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Application Information

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IPC IPC(8): C07C227/02C07C227/40C07C229/60B01J31/24
Inventor 蒋敏
Owner HANGZHOU JUNLING PHARM TECH CO LTD