Recombinant receptor binding protein and recombinant receptor protein for detecting new coronavirus neutralizing antibody

A receptor binding and receptor protein technology, applied in the field of biomedicine, can solve problems such as insufficient binding stability, false negatives, and restrictions on the continuous detection of neutralizing antibodies against the new coronavirus, and meet the needs of tracking and detection of neutralizing antibodies. The effect of simple operation and low detection cost
CN112707968AActive Publication Date: 2021-04-27SUZHOU CUREMED BIOMEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU CUREMED BIOMEDICAL TECH CO LTD
Publication Date
2021-04-27

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Abstract

The invention belongs to the field of biological medicines, and relates to a recombinant receptor binding protein and a recombinant receptor protein for detecting a new coronavirus neutralizing antibody, in particular to the recombinant receptor binding protein, the recombinant receptor protein, a nucleic acid molecule, a recombinant expression vector, a recombinant host cell, a reagent composition, a kit and application. The recombinant receptor binding protein is an RBD trimer protein, the RBD trimer protein has an optimized spatial structure and higher immunogenicity, the recombinant receptor protein is an ACE2 dimer protein, the ACE2 dimer protein has a natural protein conformation capable of simulating ACE2, after the recombinant receptor binding protein and the recombinant receptor protein are combined, the new coronavirus neutralizing antibody can be detected through the principle of enzyme linked immunosorbent assay, the sensitivity, specificity and stability are remarkably improved, and the requirement for tracking detection of the new coronavirus neutralizing antibody on the market can be greatly met.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to a recombinant receptor-binding protein and a recombinant receptor protein for detecting neutralizing antibodies against the new coronavirus; specifically, the disclosure relates to a recombinant receptor-binding protein, a recombinant Receptor protein, nucleic acid molecule, recombinant expression vector, recombinant host cell, reagent composition, kit and application. Background technique

[0002] Novel coronavirus disease 2019 (COVID-19), referred to as "new coronary pneumonia", is a pneumonia caused by severe acute respiratory syndrome coronavirus 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2). SARS-CoV-2 is a single-stranded RNA (ssRNA) virus, following the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (Middle East respiratory syndrome coronavirus, MERS- CoV), the third outbreak of coronavirus among peo...

Claims

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