Mesoporous polydopamine nanoparticles for tumor T1-T2 magnetic resonance imaging

A mesoporous polydopamine and nanoparticle technology, applied in the field of biomedical materials, can solve the problems of not having T1-T2 dual-mode imaging effect and limiting the application of tumor diagnosis and treatment, and achieve good photothermal conversion ability, accurate MRI results, good dispersion effect
CN112759762AActive Publication Date: 2021-05-07SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2021-05-07

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Abstract

The invention belongs to the technical field of biomedical materials, particularly relates to mesoporous polydopamine (MPDA) nanoparticles for tumor T1-T2 magnetic resonance imaging, and aims to prepare mesoporous polydopamine nanoparticles which are internally doped with metal and have a T1-T2 bimodal imaging effect. The manganese-mesoporous polydopamine nanoparticles are prepared by taking dopamine hydrochloride and an Mn precursor as basic raw materials and taking F127 and TMB as templates, and the nanoparticles are polydopamine nanoparticles which are internally doped with metal manganese and have a mesoporous structure, and have tumor microenvironment responsiveness, good photothermal conversion capability and good photothermal stability; the nanoparticles have good biocompatibility, and can be used as a T1 contrast agent and a T2 contrast agent for magnetic resonance imaging of tumors at the same time.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a mesoporous polydopamine nanoparticle used for tumor T1-T2 magnetic resonance imaging. Background technique

[0002] Magnetic resonance imaging (MRI) has attracted extensive attention due to its advantages of high temporal and spatial resolution, no limitation of penetration depth, and no radiation damage. Magnetic resonance contrast agents can enhance MRI signal by reducing the relaxation time of T1 or T2 water protons. T1 is called the longitudinal relaxation time, which is usually used to increase the visualization saturation and suppress the magnetic resonance signal intensity or imaging intensity. Since tissues usually have a long longitudinal relaxation time, T1-weighted images are suitable for observing adipose tissue or anatomical structures. T2 is called the transverse relaxation time, and the proton spin in the lesion usually has a longer rela...

Claims

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