Antibacterial chitosan-based hemostatic patch

Abstract

The invention discloses an antibacterial chitosan-based hemostatic patch, which comprises a back lining layer, a hemostatic layer and a protective layer which are sequentially arranged from bottom to top; the back lining layer is a base material prepared from polypropylene or polyethylene terephthalate, and an adhesive is coated on the back lining layer; the hemostatic layer comprises a non-woven fabric on the lower side and a composite hemostatic material on the upper side, and the composite hemostatic material is composite hydrogel prepared from modified chitosan, polyethylene glycol 2000, gelatin, xanthan gum, a tea polysaccharide-nano-selenium compound, dopamine modified nano-silica and oleamide; and the protective layer is a PET (Polyethylene Terephthalate) film. The antibacterial chitosan-based hemostatic patch provided by the invention is convenient to store, carry and use, does not stimulate wounds, has good antibacterial and anti-infection effects, can realize rapid blood coagulation through adhesion sealing and activation of a blood coagulation system, and can avoid the occurrence of side effects of vascular embolism.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an antibacterial chitosan-based hemostatic patch. Background technique [0002] Studies have shown that chitosan can adhere to and aggregate red blood cells and platelets, activate the coagulation pathway through the activation of platelets, accelerate the synthesis of fibrin glue, stimulate vasoconstriction, and finally seal the wound. At the same time, chitosan also has certain antibacterial, pain relieving, promoting wound healing and reducing scar effects, and is an ideal hemostatic material. However, pure chitosan materials, including gels and fibers, tend to have weak mechanical strength. Therefore, the research and development of chitosan-based composite hemostatic materials with stable properties, safety and non-toxicity, and good mechanical strength has become a hot spot. In the prior art, in order to improve the mechanical strength of the material when pr...

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Problems solved by technology

Nano-selenium has good antibacterial activity, but it is prone to aggregation and inactivation; nano-silicon dioxide has good hemostatic and water absorption properties, can activate the coagulation system, and is also a common component for preparing composite hemostatic materials, but the powder is unstable , it is easy to gather and cause the hemostatic effect to decline, and there is also the risk of powder falling off into blood vessels and causing vascular embolism. It can not only immobilize the powder to ensure its activity, so that it can fully exert the hemostatic and coagulation effect, but also avoid leakage. This is the research and development of composite hemostatic materials. problem

In order to improve the fit and adhesion of the composite hemostatic material and avoid the leakage of powdered minerals, researchers usually use the method of increasing the viscosity of the material or improving the compactness of the material, which in turn causes the hemostatic material to be difficult to separate from the wound, causing serious damage when it is removed. Problems with secondary damage or deterioration of material comfort

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