Gene editing microneedle for treating inflammatory skin diseases and application thereof

An inflammatory skin disease, gene editing technology, applied in skin diseases, microneedling, gene therapy, etc., can solve problems such as difficulty in reaching the epidermis and dermis
CN112807273AActive Publication Date: 2021-05-18ZHEJIANG UNIV
5 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2021-05-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a gene editing microneedle for treating inflammatory skin diseases and application thereof. The gene editing microneedle comprises a needle tip part and a base part, wherein the needle tip part comprises two nano compounds and a needle tip matrix, and the base part is a base matrix. The gene editing microneedle can improve the gene editing efficiency, deliver the retention of glucocorticoid drugs and gene editing ribonucleoprotein compounds in the skin, and synergistically improve the skin inflammation environment. The microneedle has the skin barrier function of repairing skin lesion tissues, thereby achieving the inflammatory process of relieving psoriasis and atopic dermatitis. The invention also provides the application of the gene editing microneedle in the preparation of drugs for treating inflammatory skin diseases.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the fields of pharmacy, biotechnology, polymer chemistry, cell biology, etc., and specifically relates to a gene editing microneedle for treating inflammatory skin diseases and its application. It is a new type of microneedle patch to deliver gene-edited ribonucleoprotein complexes, as well as the application of drugs for the preparation of inflammatory skin diseases. Background technique

[0002] Inflammatory skin diseases (ISDs) are a group of common diseases in life, and their pathological features are the activation of innate and adaptive immune responses through the production of pro-inflammatory cytokines. Among various inflammatory skin diseases, psoriasis and atopic dermatitis are increasingly becoming the main problems that threaten public health, and the course of the disease lasts for a long time, making it difficult to be completely cured. Psoriasis is an immune-mediated inflammatory skin disease characterized clin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More