Hydrogen sulfide colorimetric sensor for targeted induction of mimic enzyme inactivation based on mixed node metal organic framework material

A technology of hydrogen sulfide and simulated enzymes, which is applied in the direction of analyzing materials through chemical reactions, material analysis through observing the impact on chemical indicators, color/spectral characteristic measurement, etc., which can solve the limitations of colorimetric sensor applications, single The problem of unsatisfactory catalytic activity of component MOFs has achieved obvious selectivity, improved sensitivity and selectivity, and simple operation

Inactive Publication Date: 2021-06-04
SHANGQIU NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the unsatisfactory catalytic activity of single-component MOFs limits their application in colorimetric sensors.

Method used

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  • Hydrogen sulfide colorimetric sensor for targeted induction of mimic enzyme inactivation based on mixed node metal organic framework material
  • Hydrogen sulfide colorimetric sensor for targeted induction of mimic enzyme inactivation based on mixed node metal organic framework material
  • Hydrogen sulfide colorimetric sensor for targeted induction of mimic enzyme inactivation based on mixed node metal organic framework material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 Cu-Fe MOFs as the preparation method of artificial mimetic enzyme

[0027] Add 10 mg of organic ligand biphenyl-3,4,5-tricarboxylic acid (H 3 PTC) to dissolve, then add 0.14mL freshly prepared 0.2mol / L ferric nitrate nonahydrate (FeH 18 N 3 o 18 ) and 0.4mL 0.2mol / L copper nitrate trihydrate (Cu(NO 3 ) 2 ·3H 2 0), finally add glacial acetic acid 0.5mL. Seal the bottle (20mL) with a cap with a polytetrafluoroethylene gasket, sonicate until the solution is clear, put it in a blast drying oven preheated at 85°C for 19h, cool to room temperature, and wash with DMF and CH 2 Cl 2 The products were washed 2 to 3 times respectively, and finally dried naturally in the air to obtain the target product.

Embodiment 2

[0028] Morphology and structure analysis of embodiment 2Cu-Fe MOFs

[0029] In order to prove the successful preparation of Cu-Fe MOFs, a series of characterizations were carried out on their morphology and structure, such as figure 2 As shown, it can be seen from the scanning electron microscope (SEM) image that Cu-Fe MOFs are composed of petal-shaped elliptical aggregates, which are composed of cross-linked sheets with a size of 5-10 microns (μm); X-ray energy spectrum (EDS) analysis revealed that the atomic ratio of Cu / Fe in Cu-Fe MOFs was 2 / 1; X-ray diffraction (XRD) patterns showed that the as-prepared samples were crystalline. From these characterization results, it can be seen that Cu-FeMOFs have been successfully prepared.

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Abstract

The invention relates to a hydrogen sulfide colorimetric sensor for targeted induction of mimic enzyme inactivation based on a mixed node metal organic framework material, and belongs to the technical field of biosensor environment detection. The synthetic Cu-Fe MOFs with mixed nodes are used as an artificial mimic enzyme to catalyze H2O2 to oxidize 3,3,5,5-tetramethylbenzidine (TMB) to generate oxTMB, and the solution is changed from colorless to blue; when dissolved H2S is added, H2S and Cu 2+ have strong binding capacity under an acidic condition; therefore, the mimic enzyme is inactivated, so that the capability of oxidizing TMB by H2O2 is weakened. then, along with the increase of the H2S concentration, the catalytic activity of the mimic enzyme is gradually reduced, and the color is obviously and gradually lightened, so that the qualitative or quantitative detection of H2S can be realized through an ultraviolet spectrophotometer or the color change. Based on the concerted catalysis of Cu-Fe in the Cu-Fe MOFs, the sensitivity and selectivity of H2S determination are improved. The method has a good application prospect in water quality analysis and environmental protection.

Description

technical field [0001] The invention relates to the preparation of a novel functional nanocomposite material based on a mixed node copper-iron bimetallic organic framework material, which is used for the detection of hydrogen sulfide in the environment, and belongs to the technical field of biosensor environmental detection. Background technique [0002] As a class of highly porous crystalline materials, metal-organic frameworks (MOFs) are of great interest in target analysis due to their superior framework and structural properties (such as extremely high specific surface area, large functional sites, and porosity). play an important role in object sensing. For MOFs materials, the large number of coordination nodes and organic linkers can generate an infinite number of possible combinations. Their pore sizes range from a few angstroms to a few nanometers, and their structures can be tuned for different target molecules by choosing metal ions and organic linkers. Therefore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N21/33
CPCG01N21/78G01N21/33
Inventor 周艳丽周奋奋张建伟董辉徐茂田
Owner SHANGQIU NORMAL UNIVERSITY
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