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Efficient anticoagulant functional molecule, chelate, application of chelate, bionic functional material and preparation method of bionic functional material

A functional molecule and chelate technology, applied in the field of biomimetic materials, can solve the problems of short-term, single anticoagulation method, complicated steps, and complicated process, so as to reduce the formation of thrombus, improve the anticoagulation effect, and improve the effect of anticoagulation effect.

Active Publication Date: 2021-06-08
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current anticoagulant methods in blood-contact materials are usually relatively single, and generally block the coagulation pathway through drug release, thereby inhibiting coagulation.
In addition, some anticoagulant methods dissolve the formed early thrombus by constructing a coating with fibrinolytic function on the surface of the material. This method can only temporarily eliminate the formed thrombus, but cannot inhibit the formation of thrombus.
However, in the prior art, there are very few materials that can simultaneously inhibit coagulation and dissolve early thrombus, and there are several reasons for this: 1. To achieve simultaneous inhibition of coagulation and fibrinolysis usually requires the simultaneous action of multiple functional molecules or drugs; 2. The encapsulation process is complicated, and the steps and processes are cumbersome; 3. The stability of the formed functional coating and the controlled drug release are unstable; 4. The effect of the anticoagulant material is single

Method used

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  • Efficient anticoagulant functional molecule, chelate, application of chelate, bionic functional material and preparation method of bionic functional material
  • Efficient anticoagulant functional molecule, chelate, application of chelate, bionic functional material and preparation method of bionic functional material
  • Efficient anticoagulant functional molecule, chelate, application of chelate, bionic functional material and preparation method of bionic functional material

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preparation example Construction

[0052] The functional molecules provided in the examples of the present invention are prepared by conventional synthesis methods in the prior art, and will not be described in detail here.

[0053] Further, the embodiment of the present invention also provides a high-efficiency anticoagulant chelate, the chelate contains metal ions and the above-mentioned high-efficiency anticoagulant functional molecules, and the ring of the metal ion and the high-efficiency anticoagulant functional molecule Chelated nuclei. And the chelation between the metal ion and the ring-shaped mother nucleus is performed by using the metal ion to chelate with the nitrogen atom of the ring-shaped mother nucleus. The metal ions are chelated with the above-mentioned high-efficiency anticoagulant functional molecules, so that the chelate can not only actively inhibit coagulation by promoting the release of NO, but also passively inhibit coagulation through fibrinolysis and improve the anticoagulant effect....

Embodiment 1

[0068] This embodiment provides a highly efficient anticoagulant functional molecule whose structural formula is as follows:

[0069]

[0070] The characterization results of the highly effective anticoagulant functional molecules provided in this example can be found in figure 1 and figure 2 According to the results of NMR and mass spectrometry, the functional molecules were successfully synthesized according to the design.

[0071] This embodiment also provides that the aforementioned highly effective anticoagulant functional molecule was synthesized and provided by Suzhou Qiangyao Biotechnology Co., Ltd.

Embodiment 2

[0073] The present embodiment provides a kind of high-efficiency anticoagulant chelate, and its structural formula is as follows:

[0074]

[0075] The present embodiment provides a kind of preparation method of above-mentioned chelate, comprises the following steps:

[0076] Mix ultrapure water with the functional molecules provided in Example 1 to form a solution with a concentration of 0.1 mg / mL, and then configure CuCL with DI water 2 .2H 2 O solution is added to the above solution, so that the concentration of copper ions in the final solution is 0.01mg / mL (the concentration of copper ions in the final solution here refers to the concentration of copper ions when they are not chelated, that is, adding CuCl 2 .2H 2 O solution moment, when chelation reaction does not take place yet, the concentration of copper ion in this mixed solution), make it react 2h under the condition of slight shock, prepare the solution that contains chelate.

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Abstract

The invention relates to the field of biomimetic materials, in particular to an efficient anticoagulant functional molecule, a chelate, application of the chelate, a biomimetic functional material and a preparation method of the biomimetic functional material. The functional molecule has a cyclic nucleus that can chelate metal ions that promote the release of NO, can specifically bind to an amino acid group of plasminogen and a reactive group that can react with a carrier material so that the functional molecule is grafted to the carrier material; and the amino acid group and the reaction group are respectively bonded with the cyclic parent nucleus through chemical bonds. The efficient anticoagulant functional molecule can effectively chelate metal ions so as to catalyze NO release and inhibit thrombus formation, meanwhile, the chelate can effectively capture plasminogen and dissolve formed thrombus so as to achieve efficient anticoagulation, and meanwhile, through reaction, the functional molecule can be rapidly and efficiently grafted to the surfaces of various materials without side effects, and can stably exert an anticoagulant function.

Description

technical field [0001] The invention relates to the field of bionic materials, in particular to a highly efficient anticoagulant functional molecule, a chelate compound and its application, a bionic functional material and a preparation method thereof. Background technique [0002] Biomimetic vascular endothelium has always been an important research content of tissue engineering. Immobilizing biomolecules on the surface of biomaterials is a relatively common and effective means. The surface of materials can be modified or modified by immobilizing a variety of molecules with specific biological functions. However, the current anticoagulant methods in blood-contact materials are usually relatively single, and generally release drugs to block the coagulation pathway, thereby inhibiting coagulation. In addition, some anticoagulant methods dissolve the formed early thrombus by constructing a coating with fibrinolytic function on the surface of the material. This method can only ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/062C07D257/02A61K38/05A61P7/02A61L33/12A61L33/00
CPCC07K5/06026C07D257/02A61P7/02A61L33/128A61L33/0041A61K38/00Y02A50/30
Inventor 杨志禄肖雨黄楠涂秋芬熊开琴
Owner SOUTHWEST JIAOTONG UNIV
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