Locally administered kudzuvine root related pharmaceutical composition

Abstract

The invention provides preparation of an effective dose of puerarin or pharmaceutically acceptable salts thereof and the like and an effective dose of brimonidine or pharmaceutically acceptable salts thereof or / and an effective dose of anti-xerophthalmia pharmaceutical composition. The invention also relates to an application of the compound in preparation of ophthalmic medicines for preventing or treating intraocular pressure of human or mammals or treating intraocular pressure rise, glaucoma, fundus diseases, xerophthalmia or dry eye diseases or dry eye syndromes, and local medicines for acne rosacea, erythema rosacea and the like. The medicine provided by the invention has better curative effect or lower side effect or better treatment compliance or better treatment mode.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular provides effective doses of brimonidine for the prevention or treatment of increased intraocular pressure, glaucoma, fundus diseases, such as retinal arteriovenous occlusion, optic atrophy, inflammatory skin diseases, etc. The pharmaceutical composition and application of puerarin or its pharmaceutically acceptable salt and effective dosage of puerarin or its pharmaceutically acceptable salt or its solvate or hydrate. Background technique [0002] Glaucoma (glaucoma) is a group of optic nerve diseases, including the loss of retinal ganglion cells. It is the second most blind eye disease in the world. If it is not treated in time, it will cause visual field defect or complete loss, leading to blindness. It is the most important cause of irreversible blindness. reason. The onset of glaucoma is rapid and harmful. Increased pathological intraocular pressure (IOP) is the most i...

AI Technical Summary

Problems solved by technology

However, this treatment modality poses some difficulties, such as having to give one drug, wait a few minutes, and then give the second drug

Also, since brimonidine needs to be dosed three times a day while puerarin only needs to be taken twice, this may cause some additional difficulties for the patient, either remembering a single brimonidine dose or administering puerarin by chance

In the long-term medication process, there will be problems with the compliance of the treatment medication. Once the patient has this problem, the intraocular pressure may suddenly rise due to the inability or inaccuracy of the medication or the interruption of the treatment, resulting in head or Physical discomfort or serious consequences, or severe blindness of the patient, or even death, In addition, studies have also shown that adverse events may increase as a result of this combination concurrent therapy

[0011] However, due to factors such as the long course of glaucoma and complicated treatment, some glaucoma patients may not be able to strictly follow the doctor's prescription for medication, and the medication compliance is poor, which directly affects the treatment effect and prolongs the treatment time, which is not conducive to the rapid recovery of the disease.

The above two drugs still have insufficient effects in the treatment of glaucoma, and literature reports that up to 75% of glaucoma patients need to combine two or more drugs for IOP to drop to the expected value

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