Preparation method of flexible brain nerve electrode coating and electrode assembled by flexible brain nerve electrode coating

An electrode coating and brain technology, applied in coatings, sensors, diagnosis, etc., can solve the problems of increasing the impedance of metal electrode sites, the coating is fragile, and it takes hours or even days to achieve Reducing chronic inflammatory response, reducing acute inflammatory response, good structural regularity

Active Publication Date: 2021-06-22
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method still has serious flaws
First, most coating materials are polymers, which are difficult to dissolve in non-toxic and harmless solvents such as deionized water and normal saline; second, the complete evaporation of solvents takes hours or even days, which greatly reduces the production cost. Efficiency; third, because the coating material is diluted by solvent, the processed coat...

Method used

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  • Preparation method of flexible brain nerve electrode coating and electrode assembled by flexible brain nerve electrode coating
  • Preparation method of flexible brain nerve electrode coating and electrode assembled by flexible brain nerve electrode coating
  • Preparation method of flexible brain nerve electrode coating and electrode assembled by flexible brain nerve electrode coating

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Embodiment 1

[0047] Such as figure 1 As shown in the flowchart, it operates in an operating room environment. The analytically pure polyethylene glycol with a viscosity average molecular weight of 10000g / mol, pharmaceutical grade dexamethasone, and polylactic acid-glycolic acid copolymer loaded pharmaceutical grade dexamethasone nanoparticles were mixed in a mass ratio of 7:2:1 inside the beaker. Subsequently, the mixture was heated on a hot plate at a temperature of 120° C. for 5 minutes, and after the polyethylene glycol component was melted, the mixture was stirred at a constant temperature for 10 minutes to uniformly mix the components. Subsequently, the mixture was left to cool at room temperature for 3 min. Subsequently, place the cooled mixture in a mortar and grind it into fine particles, and use a microscope to observe to ensure that the particle size is controlled between 0.2mm-0.5mm (too coarse particles are difficult to embed into polydimethylsiloxane mold needle-shaped in...

Embodiment 2

[0051] Such as figure 1 As shown in the flowchart, it operates in an operating room environment. The analytically pure polyethylene glycol with a viscosity average molecular weight of 20000g / mol, pharmaceutical grade dexamethasone, and polylactic acid-glycolic acid copolymer loaded pharmaceutical grade dexamethasone nanoparticles were mixed in a mass ratio of 8:1:1 inside the beaker. Subsequently, the mixture was heated on a hot plate at a temperature of 120° C. for 5 minutes, and after the polyethylene glycol component was melted, the mixture was stirred at a constant temperature for 10 minutes to uniformly mix the components. Subsequently, the mixture was left to cool at room temperature for 3 min. Subsequently, the cooled mixture is ground into fine particles in a mortar and observed with a microscope to ensure that the particle size is controlled between 0.2 mm and 0.5 mm. Use tweezers to embed the granular mixture as figure 2 The needle-shaped flow channel 2 of the...

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Abstract

The invention discloses a preparation method of a flexible brain nerve electrode coating and an electrode assembled by the flexible brain nerve electrode coating, and relates to the field of implantable medical device. Polyethylene glycol, medicinal dexamethasone and polylactic acid-glycolic acid copolymer loaded medicinal dexamethasone nanoparticles are mixed in a beaker to form a mixture, and a composite coating is prepared in a specific mold and is connected with the flexible brain nerve electrode through polyvinyl alcohol. The flexible brain nerve electrode composite coating which has relatively high mechanical hardness and strength and can continuously release anti-inflammatory drugs can be rapidly, simply and conveniently prepared, and implantation of the flexible brain nerve electrode is assisted. Polyvinyl alcohol can be completely hydrolyzed within 1 min, the composite coating can be rapidly separated from the neural electrode after implantation, no polymer adheres to the metal electrode site of the neural electrode, normal recording of the electrode on the bio-electricity signal is not affected, and the slow-release anti-inflammatory drug can relieve the inflammatory response of tissue.

Description

technical field [0001] The invention relates to the field of implantable medical devices, in particular to a preparation method of a flexible brain nerve electrode coating and assembled electrodes. Background technique [0002] Currently, implantable brain nerve electrodes have been widely used in the clinical treatment of neurological diseases. The structure of traditional silicon-based electrodes is hard, and after implantation, there will be a mechanical mismatch with the soft cerebral cortex tissue, which will cause rejection reactions such as irritating trauma, tissue wrapping, and chronic inflammation. In order to solve the above problems, flexible brain nerve electrodes based on soft materials (such as polyimide, parylene, SU8 photoresist) have emerged. Compared with silicon-based electrodes, the Young's modulus of flexible brain nerve electrodes is closer to that of cerebral cortex tissue, which greatly improves the mechanical adaptability between electrodes and tis...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16A61L31/14A61B5/293
CPCA61L31/10A61L31/16A61L31/148A61L2300/41A61L2300/222C08L29/04C08L67/04C08L71/02
Inventor 张文光周旭晖许李悦贺雨欣
Owner SHANGHAI JIAO TONG UNIV
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