Preparation method of flexible brain nerve electrode coating and electrode assembled by flexible brain nerve electrode coating

Abstract

The invention discloses a preparation method of a flexible brain nerve electrode coating and an electrode assembled by the flexible brain nerve electrode coating, and relates to the field of implantable medical device. Polyethylene glycol, medicinal dexamethasone and polylactic acid-glycolic acid copolymer loaded medicinal dexamethasone nanoparticles are mixed in a beaker to form a mixture, and a composite coating is prepared in a specific mold and is connected with the flexible brain nerve electrode through polyvinyl alcohol. The flexible brain nerve electrode composite coating which has relatively high mechanical hardness and strength and can continuously release anti-inflammatory drugs can be rapidly, simply and conveniently prepared, and implantation of the flexible brain nerve electrode is assisted. Polyvinyl alcohol can be completely hydrolyzed within 1 min, the composite coating can be rapidly separated from the neural electrode after implantation, no polymer adheres to the metal electrode site of the neural electrode, normal recording of the electrode on the bio-electricity signal is not affected, and the slow-release anti-inflammatory drug can relieve the inflammatory response of tissue.

Description

technical field [0001] The invention relates to the field of implantable medical devices, in particular to a preparation method of a flexible brain nerve electrode coating and assembled electrodes. Background technique [0002] Currently, implantable brain nerve electrodes have been widely used in the clinical treatment of neurological diseases. The structure of traditional silicon-based electrodes is hard, and after implantation, there will be a mechanical mismatch with the soft cerebral cortex tissue, which will cause rejection reactions such as irritating trauma, tissue wrapping, and chronic inflammation. In order to solve the above problems, flexible brain nerve electrodes based on soft materials (such as polyimide, parylene, SU8 photoresist) have emerged. Compared with silicon-based electrodes, the Young's modulus of flexible brain nerve electrodes is closer to that of cerebral cortex tissue, which greatly improves the mechanical adaptability between electrodes and tis...

AI Technical Summary

Problems solved by technology

However, this method still has serious flaws

First, most coating materials are polymers, which are difficult to dissolve in non-toxic and harmless solvents such as deionized water and normal saline; second, the complete evaporation of solvents takes hours or even days, which greatly reduces the production cost. Efficiency; third, because the coating material is diluted by solvent, the processed coating is extremely fragile and very inconvenient to handle; fourth, the injection molding method will make the metal sites of the flexible brain nerve electrodes adhere to the polymer, This will have an extremely adverse effect on the electrical characteristics of the electrode (such as increasing the impedance of the metal electrode site, weakening the spatial signal resolution of the metal electrode site)

Images