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Polyoxyethylene polyoxypropylene-chitosan block copolymer, bone hemostatic material and preparation method thereof

A polyoxyethylene polyoxypropylene, block copolymer technology, applied in the field of medicine, can solve the problems of long-term retention of foreign matter in the body, prone to infection and pain, and inability to be absorbed by the body, so as to increase the molecular weight and high product quality rate , Improve the effect of biocompatibility

Active Publication Date: 2022-04-01
北京市创伤骨科研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bone wax is non-degradable and cannot be absorbed by the body, and has poor biocompatibility. It is easy to stay in the body as a foreign body for a long time, hindering bone repair, and is prone to foreign body reactions such as infection and pain.
[0003] In addition, the existing bone hemostatic material products are completely water-soluble components, and the surface quickly liquefies when it meets blood, resulting in a decrease in the sealing strength, so the hemostatic effect is not good. At the same time, the existing bone hemostatic materials are often in the form of sponge or powder. The hemostatic effect is remarkable in conventional soft tissue bleeding, but the hemostatic effect is often unsatisfactory when applied to spongy bone wounds

Method used

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  • Polyoxyethylene polyoxypropylene-chitosan block copolymer, bone hemostatic material and preparation method thereof
  • Polyoxyethylene polyoxypropylene-chitosan block copolymer, bone hemostatic material and preparation method thereof
  • Polyoxyethylene polyoxypropylene-chitosan block copolymer, bone hemostatic material and preparation method thereof

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preparation example Construction

[0048] According to a first aspect of the present invention, a kind of preparation method of polyoxyethylene polyoxypropylene-chitosan block copolymer is provided, comprising the steps:

[0049] (a) react polyoxyethylene polyoxypropylene block copolymer and activator in solvent, precipitate, solid-liquid separation, obtain activated polyoxyethylene polyoxypropylene block copolymer;

[0050] (b) Chitosan and the activated polyoxyethylene polyoxypropylene block copolymer obtained in step (a) carry out graft copolymerization reaction in acid solution, precipitate, and separate solid and liquid to obtain polyoxyethylene polyoxypropylene-shell Polysaccharide block copolymers;

[0051] Wherein, the activator includes N,N'-carbonyldiimidazole.

[0052] The present invention adopts a two-step method to synthesize polyoxyethylene polyoxypropylene-chitosan block copolymer, and first utilizes N,N'-carbonyldiimidazole to activate the polyoxyethylene polyoxypropylene block copolymer conta...

Embodiment 1

[0099] A kind of preparation method of polyoxyethylene polyoxypropylene-chitosan block copolymer, comprises the steps:

[0100] (1) Synthetic activated polyoxyethylene polyoxypropylene block copolymer:

[0101] Dissolve 30g of polyoxyethylene polyoxypropylene block copolymer, 5.89g of N,N'-carbonyldiimidazole in 150ml of 1,4-dioxane and dimethyl sulfoxide with a volume ratio of 2:1 In the reagent, the reaction was stirred for 12 h at a temperature of 37 °C. After the reaction, stir under ice-bath conditions and add anhydrous ether dropwise, filter to obtain a precipitate, wash three times with anhydrous ether, and vacuum-dry to obtain an activated polyoxyethylene polyoxypropylene block copolymer as a white precipitate.

[0102] (2) Synthetic polyoxyethylene polyoxypropylene-chitosan block copolymer:

[0103] Dissolve 4g of chitosan and 8g of activated polyoxyethylene polyoxypropylene block copolymer in 0.1mol / L hydrochloric acid solution, stir for 12h at a temperature of 37°...

Embodiment 2

[0107] A kind of preparation method of polyoxyethylene polyoxypropylene-chitosan block copolymer, comprises the steps:

[0108] (1) Synthetic activated polyoxyethylene polyoxypropylene block copolymer:

[0109] Dissolve 50g of polyoxyethylene polyoxypropylene block copolymer and 9.75g of N,N'-carbonyldiimidazole in 200ml of 1,4-dioxane and dimethyl sulfoxide mixed reagent with a volume ratio of 2:1 , the reaction was stirred at a temperature of 37° C. for 12 h. After the reaction, stir under ice-bath conditions and add anhydrous ether dropwise, filter to obtain a precipitate, wash three times with anhydrous ether, and vacuum-dry to obtain an activated polyoxyethylene polyoxypropylene block copolymer as a white precipitate.

[0110] (2) Synthetic polyoxyethylene polyoxypropylene-chitosan block copolymer:

[0111] Dissolve 6g of chitosan and 8g of activated polyoxyethylene-polyoxypropylene block copolymer in 0.1mol / L hydrochloric acid solution, stir for 12h at a temperature of...

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Abstract

The invention provides a polyoxyethylene-polyoxypropylene-chitosan block copolymer, a bone hemostatic material and a preparation method thereof, and relates to the field of medical technology. The preparation method of the invention adopts a two-step method to synthesize polyoxyethylene-polyoxypropylene ‑Chitosan block copolymer, first use N,N′‑carbonyldiimidazole to activate polyoxyethylene polyoxypropylene block copolymer with hydroxyl groups at both ends to obtain activated polyoxyethylene polyoxypropylene block copolymer, Carry out graft copolymerization reaction with chitosan again, obtain polyoxyethylene polyoxypropylene-chitosan block copolymer. The polyoxyethylene polyoxypropylene-chitosan block copolymer of the present invention can be used as a raw material for preparing bone hemostatic materials, can improve the biocompatibility and bacteriostasis of bone hemostatic materials, and can prolong the hemostatic time and reduce the dissolution rate and improve water absorption.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a polyoxyethylene polyoxypropylene-chitosan block copolymer, a bone hemostatic material and a preparation method thereof. Background technique [0002] Clinically, bone destruction is often involved in orthopedic, neurosurgery, and thoracic surgery procedures, resulting in bleeding from cancellous bone wounds. The cancellous bone structure is loose and the blood supply is rich, and the wound bleeding is mostly oozing. It is difficult to stop bleeding by vasoconstriction, and it is also difficult to stop bleeding by conventional methods such as hemostatic gauze, electrocoagulation, gelatin sponge packing, and forceps. Currently, bone wax is commonly used clinically for hemostasis of cancellous bone wounds. The components of traditional bone wax mainly include beeswax and petroleum jelly. It can stop bleeding on cancellous bone wounds through physical packing, and its hemostasis ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00A61L24/00A61L24/02A61L24/04A61L24/08A61L27/02A61L27/10A61L27/12A61L27/18A61L27/20A61L27/54A61L27/58
CPCC08G81/00A61L24/08A61L24/046A61L24/02A61L24/0015A61L24/0042A61L27/20A61L27/18A61L27/12A61L27/025A61L27/10A61L27/54A61L27/58A61L2400/04A61L2300/232A61L2300/404A61L2300/418A61L2300/254A61L2300/604A61L2430/02C08L87/005C08L71/02
Inventor 石锐薛芸
Owner 北京市创伤骨科研究所