Preparation method and application of biochemical sensor

A biochemical and sensor technology, applied in the field of new nano-functional materials, can solve the problems of limited application, low charge transfer ability, high recombination rate, etc., and achieve the effect of short response time, improved strength and stability, and good energy band matching

Inactive Publication Date: 2021-07-09
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the high recombination rate of photogenerated electron-hole pairs and low charge transfer ability limit its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation of antimony tungstate microspheres co-doped with cerium and silver:

[0038] Dissolve 0.3 g of sodium tungstate hydrate in 8 mL of ultrapure water, called solution A; dissolve 0.4 g of antimony trichloride in 8 mL of absolute ethanol, called solution B, slowly drop solution B into In solution A, a light yellow solution was obtained after stirring for 10 min. Add 0.03 mg of silver nitrate and 0.08 mg of cerium nitrate hydrate to the above solution. After stirring for 30 min, adjust the pH with 1 mol / L sodium hydroxide solution or nitric acid solution to 2. Continue stirring for 10 min, transfer the resulting solution to an autoclave, and react at 180 °C for 18 h. After the autoclave is gradually cooled to room temperature, take out the product, wash it with ethanol and ultrapure water for 3 times, and dry it in vacuum for 10 h. .

Embodiment 2

[0039] Example 2 Preparation of antimony tungstate microspheres co-doped with cerium and silver:

[0040] Dissolve 0.5 g of sodium tungstate hydrate in 8 mL of ultrapure water, called solution A; dissolve 0.6 g of antimony trichloride in 8 mL of absolute ethanol, called solution B, slowly drop solution B into In solution A, a light yellow solution was obtained after stirring for 10 min. Add 0.05 mg of silver nitrate and 0.12 mg of cerium nitrate hydrate to the above solution. After stirring for 30 min, adjust the pH with 1 mol / L sodium hydroxide solution or nitric acid solution to 2. Continue stirring for 10 min, transfer the resulting solution to an autoclave, and react at 180 °C for 24 hours. After the autoclave is gradually cooled to room temperature, take out the product, wash it with ethanol and ultrapure water for 4 times, and dry it in vacuum for 16 h. .

Embodiment 3

[0041] Embodiment 3 Preparation of indium sulfide:

[0042] Dissolve 0.2 g of indium nitrate hydrate in 80 mL of ultrapure water, add 0.10 g of thioacetamide to the above solution, stir for 30 min, transfer the resulting solution to an autoclave, and react at 120 °C for 10 h. After the kettle was gradually cooled to room temperature, the product was taken out, washed 3 times with ethanol, and dried in vacuum for 6 h.

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PUM

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Abstract

The invention relates to a preparation method and application of a biochemical sensor. The cerium and silver doped antimony tungstate is used as a substrate material, the large specific surface area of the cerium and silver doped antimony tungstate can increase capture of light and loading of biomolecules, doping of cerium and silver elements can provide an electronic path, a plasma effect is caused, and the separation efficiency of photo-generated charges is improved. Silver sulfide grows on cerium and silver doped antimony tungstate through in-situ consumption of part of silver ions by adopting a dipping method, and meanwhile, an energy band matching structure formed by modifying indium sulfide on cerium and silver doped antimony tungstate/silver sulfide has good photoelectric response. On the other hand, cadmium sulfide/polydopamine with excellent conductivity is used as a signal marker, polydopamine can be directly combined with biomolecules through Michael addition or Schiff base, cadmium sulfide can be better matched with cerium and silver doped antimony tungstate/silver sulfide/indium sulfide in energy bands, and the photoelectric conversion efficiency of the sensor is effectively improved. The biochemical sensor constructed based on the method has a wide linear range and high sensitivity, and has important significance on detection of a small cell lung cancer marker neuron-specific enolase.

Description

technical field [0001] The invention relates to the technical fields of novel nanometer functional materials, immune analysis and biochemical sensor detection, and provides a method for preparing a photoelectrochemical sensor based on cerium and silver co-doped antimony tungstate / silver sulfide / indium sulfide composite materials. Background technique [0002] Neuron-specific enolase (neuron specific enolase, NSE), also known as neuron enolase, is an isomer of enolase, which only exists in neurons and neuroendocrine cells. The positive detection of serum NSE in patients with small cell lung cancer (SCLC) can be as high as 65% to 100%. For healthy people, the serum NSE level is 5-12 ng / mL, and the cerebrospinal fluid is <20 ng / mL. In patients with lung cancer, NSE levels in the blood are altered. It has been recognized that NSE can be used as a highly specific and sensitive tumor marker for small cell lung cancer. Therefore, monitoring NSE is of great significance for the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/75G01N27/26G01N27/30G01N27/327
CPCG01N21/75G01N27/26G01N27/30G01N27/3278
Inventor 张勇刘德玲任祥马洪敏吴丹王欢范大伟李玉阳魏琴孙旭
Owner UNIV OF JINAN
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