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Sprayable hydrogel as well as preparation method and application thereof

A hydrogel and mannan technology, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, and pharmaceutical sciences, etc., can solve problems such as weak ductility, poor stability, and γ-polyglutamic acid cannot form gels. , to achieve the effect of stable performance, good ductility, simple and quick operation

Pending Publication Date: 2021-07-13
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the deficiencies and shortcomings of the prior art, the primary purpose of the present invention is to provide a preparation method of sprayable hydrogel, the preparation method by modifying gamma-polyglutamic acid to make its hydrazide group The aldehyde group with the oxidized konjac glucomannan is bonded by an acylhydrazone bond to form a uniform and stable hydrogel with a certain viscosity and rapid prototyping. This preparation method solves the problem of γ-polyglutamic acid It cannot be gelled by itself, and the gel formed by konjac glucomannan in water is not only poor in stability, but also has a technical problem of weak ductility

Method used

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  • Sprayable hydrogel as well as preparation method and application thereof
  • Sprayable hydrogel as well as preparation method and application thereof
  • Sprayable hydrogel as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1: Preparation of oxidized konjac glucomannan

[0042] Add 0.5g konjac glucomannan to 500ml deionized water, stir well, then add 0.2303g sodium periodate in the dark, react at room temperature for 6 hours, add 0.6ml ethylene glycol to terminate the oxidation reaction, and dialyze with a 3kDa cellulose dialysis bag , freeze-dried to obtain oxidized konjac glucomannan (OKGM) solid, and dried for storage.

[0043] The infrared spectrogram of the oxidized konjac glucomannan prepared in the present embodiment is as follows figure 2 shown, from figure 2 It can be seen that when the sugar ring main chain remains unchanged, the 1734cm -1 The characteristic peak consists of the 1737cm of konjac glucomannan (KGM) -1 The small shoulder peak becomes a wider peak, which is the symmetrical absorption peak of the aldehyde group and the vibration superposition peak of the acetyl group. At the same time, the 879cm -1 The absorption peak of the hemiacetal structure betwe...

Embodiment 2

[0044] Embodiment 2: Preparation of modified γ-polyglutamic acid

[0045] Pour 3% γ-sodium polyglutamate solution into a glass column equipped with 732 hydrogen-type strong acid cation exchange resin, adjust the piston of the glass column to control the liquid flow rate, and the control flow rate is 2s / drop to obtain acidified γ-polyglutamate solution. - Polyglutamic acid (γ-PGA) solution, lyophilized. Add 0.1 g of acidified γ-PGA solid to 100 mL of deionized water, adjust the pH of the reaction system to 5.5 with 5% sodium hydroxide solution, and react for 10 minutes, then add 0.0580 g of EDC and 0.0348 g of NHS to the reaction liquid in turn, and react at room temperature for 20 minutes Finally, after adjusting the pH to 8, add 0.27g of adipic acid dihydrazide, react for 24 hours, add 3% hydrochloric acid solution to adjust the pH of the system to 7, terminate the reaction, dialyze with a 3kDa cellulose dialysis bag for 3 days, and freeze-dry.

[0046] The infrared spectrog...

Embodiment 3

[0047] Embodiment 3: Hydrogel is gelled

[0048] Dissolve oxidized konjac glucomannan (OKGM) with a mass concentration of 2% in water, add methylene blue staining solution, and record it as tube A; configure a mass concentration of 5% modified γ-polyglutamic acid (P -NH 2 ) solution, denoted as tube B. At the same time, take the same volume of aqueous solution from tubes A and B into tube C, and let it stand for a while to form a sprayable hydrogel.

[0049] The sprayable hydrogel gel that present embodiment prepares is as Figure 5 As shown, it can be seen that the hydrogel is stable and mixed evenly.

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Abstract

The invention discloses sprayable hydrogel and a preparation method and application thereof. The preparation method comprises the steps that konjac glucomannan is subjected to oxidation modification with sodium periodate so as to prepare oxidized konjac glucomannan; then gamma-sodium polyglutamate is subjected to acidification and further treatment so as to obtain modified polyglutamic acid; and the sprayable hydrogel is prepared from the oxidized konjac glucomannan and the modified polyglutamic acid. The hydrogel obtained by the preparation method disclosed by the invention is stable in performance and good in ductility, and the technical problems that the gamma-polyglutamic acid cannot be gelatinized, and a gel formed by the konjac glucomannan in water is poor in stability and weak in ductility are solved. The sprayable hydrogel prepared by the preparation method disclosed by the invention can be widely applied to biomedical engineering.

Description

technical field [0001] The invention belongs to the field of biological functional materials, and in particular relates to a sprayable hydrogel and a preparation method and application thereof. Background technique [0002] Konjac glucomannan (KGM) can be extracted from natural herbs of the genus Konjac, and its sugar chains are composed of D-mannose and D-glucose linked by β-1,4 glycosidic bonds. KGM has the functions of lowering blood pressure, cholesterol, and promoting intestinal peristalsis, so it is often used to treat obesity; at the same time, it is used in the field of diabetes because it can improve the sensitivity of the pancreas to insulin; KGM can also promote macrophages to secrete anti-inflammatory factors It is used as a skin dressing to shorten the repair period of skin wounds. In addition, KGM has good biodegradability and tissue compatibility, and is widely used in biomedicine, food, agriculture and other fields. However, because KGM contains more hydrop...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L77/04C08L5/02C08B37/02C08G69/48A61L27/52A61L27/20A61L27/18A61K47/36A61K47/34A61K9/06
CPCC08J3/075C08B37/009C08G69/48A61K9/06A61K47/36A61K47/34A61L27/20A61L27/18A61L27/52C08J2377/04C08J2405/02
Inventor 毛萱祝玲汤顺清
Owner JINAN UNIVERSITY
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