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Composition for relaxing bowels or regulating intestinal flora, preparation method, application and preparation thereof

A composition and plant technology, applied in the directions of drug combinations, medical preparations containing active ingredients, applications, etc., can solve the problem of high cost of raw materials, and achieve the effects of reasonable price, excellent taste, and regulation of intestinal flora

Inactive Publication Date: 2021-07-27
哈尔滨百世普康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved by the present invention is to overcome the problem of prevention and treatment of constipation in the prior art, as well as the problem that the products for regulating intestinal flora contain anthraquinone components that are prone to side effects or the cost of raw materials is high, thereby providing a general Composition for regulating intestinal flora, preparation method, application and preparation thereof

Method used

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  • Composition for relaxing bowels or regulating intestinal flora, preparation method, application and preparation thereof
  • Composition for relaxing bowels or regulating intestinal flora, preparation method, application and preparation thereof
  • Composition for relaxing bowels or regulating intestinal flora, preparation method, application and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Comparative experiment on the yield of stachyose extracted from raw rehmannia glutinosa at different temperatures

[0076] The raw material of rehmannia root (purchased from Hebei Kangpai Traditional Chinese Medicine Decoction Pieces Factory, batch number 181126-W) was pulverized into 10-40 meshes, and 6 parts of 20 g of rehmannia root powder were weighed, and 400 g of pure water was added, and one part was ultrasonically extracted at room temperature for 90 min, and the remaining 5 parts were Parts were stirred and extracted in a water bath at 40°C, 60°C, 80°C, and 100°C for 90min, and the extract was taken by HPLC-MS method (high performance liquid chromatography: Agilent 1290; detector: mass spectrometer Agilent6430; chromatographic column: Agilent H-Plex H Na (10μm, 7.7×300mm); HPLC conditions: mobile phase using ultrapure water; flow rate: 0.2mL / min; column temperature 85°C; mass spectrometry conditions: nebulizer pressure 40psi, capillary voltage (positi...

Embodiment 2

[0080] Example 2: Preparation of sample A by mixing plant extracts

[0081] The raw material of rehmannia root (purchased from Hebei Kangpai Traditional Chinese Medicine Decoction Pieces Factory, batch number 161126-W) was crushed (10-40 mesh), extracted twice with hot water at 80±5°C, and the first water-material ratio (water weight / raw material weight) 12, stirring extraction time 60min; the second water-material ratio 8, extraction time 30min, the extract was filtered (filter screen 200 mesh), after merging and filtering the extract, ceramic membrane (Hefei Fengyun Membrane Separation Technology Co., Ltd., zirconia Ceramic membrane (0.1μm) for secondary filtration, the filtrate is concentrated by RO membrane (polyamide membrane DOW FILMTECBW30LE-400, 0.1nm) at 20-45°C, and then vacuum concentrated at 50°C under reduced pressure (-0.089MPa) to an appropriate concentration (Brix (ATAGO PAL-1): 20-40%), after UHT sterilization, directly spray-dried to obtain the water extract ...

Embodiment 3

[0086] Example 3: Preparation of sample B from plant water extract compatibility with fructooligosaccharides

[0087] 4 kinds of water extracts prepared in Example 2, 15 parts of rehmannia root water extract, 10 parts of Eucommia leaf water extract, 10 parts of angelica root water extract, 10 parts of mulberry fruit water extract, 55 parts of compatible fructooligosaccharides, Mix evenly, and make tablet, granule, or oral liquid food according to the conventional preparation process in this field.

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Abstract

The invention discloses a composition for relaxing bowels or regulating intestinal flora, a preparation method, an application and a preparation thereof. The composition for relaxing bowels or regulating intestinal flora provided by the invention comprises the following components: 15-55 parts of a rehmannia root aqueous extract, 5-25 parts of a folium cortex eucommiae aqueous extract, 5-25 parts of an angelica root aqueous extract and 5-25 parts of a mulberry fruit aqueous extract. The composition does not contain anthraquinone components, is safe, free of toxic and side effects and reasonable in price, and can achieve excellent effects of relaxing bowel and regulating intestinal flora.

Description

technical field [0001] The invention provides a composition for defecating or regulating intestinal flora, a preparation method, application and preparation thereof. Background technique [0002] At present, epidemiological survey data show that the chronic constipation population in my country widely exists in various groups, such as children, college students and the elderly; and the constipation probability of women is 1.22 to 4.56 times that of men. [0003] Moreover, studies have shown that, compared with the healthy population, the beneficial bacteria such as Bifidobacterium, Bacteroides, and Lactobacillus in the stool of the constipation group were significantly reduced, while harmful bacteria such as Fusobacterium putrefacilis, Clostridium, Enterobacter, and conditional bacteria were significantly reduced. Bacteria increased significantly. [0004] Patients with long-term constipation all have serious intestinal flora disorder, and carcinogens such as nitrosamines, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P1/10A61P1/00A23L33/105A61K31/702A61K31/733
CPCA61K36/804A61K36/46A61K36/232A61K36/605A61K31/702A61K31/733A61P1/10A61P1/00A23L33/105A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/15A23V2002/00A61K2300/00A23V2200/32A23V2250/21
Inventor 李悦王康鸿
Owner 哈尔滨百世普康生物科技有限公司
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