Preparation method of electrostatic spinning functional nanofiber film for epidermis repair

Abstract

The invention discloses a preparation method of an electrostatic spinning functional nanofiber film for epidermis repair, and belongs to the field of medical cosmetology. The preparation method comprises the following steps that: a nanofiber film with polylactic acid caprolactone as a shell layer and polyethylene glycol as a core layer is prepared through coaxial electrostatic spinning; stress is applied to the two ends of the nanofiber film, then unloading is conducted, heated absolute ethyl alcohol is evenly sprayed to the surface of the sample, low-temperature airflow is used for rapidly cooling the nanofiber film, and a winding fiber film is formed; and recombinant human epidermal growth factors are mixed into a sodium polystyrenesulfonate solution to form a negative electricity layer, the winding fiber film is immersed into a polyallylamine hydrochloride solution to form a positive electricity layer, layer-by-layer assembly is carried out, and the multi-layer composite fiber film is formed. The polylactic acid and polycaprolactone copolymer polylactic acid caprolactone serve as the shell layer of the coaxial electrostatically-spun nanofibers, the mechanical property of the fiber film is improved; and the polyethylene glycol serves as the core layer of the fibers, and the hydrophilicity and moisture permeability of the fiber film are improved.

Description

Technical field [0001] The present invention relates to the field of medical beauty, and more particularly to the preparation method of electrospinning functional nanofibers for epidermal repair. Background technique [0002] Solution electrospinning is a fiber having a smaller diameter (from nanometers to micrometers) (from nanometers to micrometers) and larger than conventional spinning processes from polymer solution or melt. The specific surface area. The electrospinning process is carried out by applying a voltage in a hundred tens of thousands of days, which is primarily based on the principle of a weaker surface tension in the charged polymer liquids based on the mutual repulsive force. Currently, there are two standard electrostatic spinning mode: vertical and horizontal. With the development of this technology, more complex nanofibers can be manufactured in a more controllable and more efficient manner. The electrospinning system consists of three main components: high v...

AI Technical Summary

Problems solved by technology

Some studies have improved its fabrication process by using parallel electrodes, rotating mandrels, or sacrificial materials, but the control over fiber geometry is still limited, especially in three-dimensional structures.

Fusion electroprinting is an effective method to achieve controllable deposition of highly ordered 3D scaffolds with non-linear fibers, but the influence of residual charge on fiber printing is not conducive to the control of fiber stacking. The process is limited by charge kinetics.

At the same time, the efficiency of preparing a certain thickness of film by electrospinning is low, and the loading process of functional materials such as the process of preparing microspheres for controlled release is also complicated and time-consuming.

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