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Dental implant with hydrophilic and antibacterial properties

A technology for dental implants and performance, applied in dental prosthesis, dentistry, dental implants, etc., can solve problems such as the hydrophilicity and antibacterial properties of dental implants that need to be improved

Active Publication Date: 2021-08-03
山东恒泰医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Referring to a dental implant disclosed in Chinese patent CN111728726A, a dental implant and a preparation method thereof, the implant is divided into two parts, the neck region and the body region along the axial direction, and the body region has osteogenic properties by controlling the surface microstructure. However, the hydrophilicity and antibacterial properties of dental implants prepared by the prior art still need to be improved.

Method used

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  • Dental implant with hydrophilic and antibacterial properties
  • Dental implant with hydrophilic and antibacterial properties
  • Dental implant with hydrophilic and antibacterial properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The antibacterial coating is made by the following steps:

[0043] Step S1, add 0.15mol hydroxyethyl methacrylate, 0.15mol triethanolamine and 200mL anhydrous tetrahydrofuran into the three-necked flask, stir well, add 100mL containing 0.15mol 2-chloro-2-oxo-1,3,2 - Tetrahydrofuran solution of dioxaphospholane, reflux at -20°C for 3 hours to obtain intermediate 1, raise the temperature to 60°C, add 20.45g of 70% trimethylamine solution to intermediate 1, and reflux 15h, obtain intermediate 2;

[0044] Step S2, add 3.89g of 2,2,5,5-tetramethyl-4-imidazolidinone into the flask, add 200mL of acetone, preheat the flask in an oil bath, wait until 2,2,5,5-tetramethyl After methyl-4-imidazolidinone is dissolved, add 15.6g of potassium carbonate, reflux for 40min, add 21.2g of 1,3-dichloropropane, continue to heat and reflux for 12h, distill off acetone under reduced pressure, add ethyl acetate, and then use deionized Washed twice with water to obtain intermediate 3;

[0045...

Embodiment 2

[0050] The antibacterial coating is made by the following steps:

[0051] Step S1, add 0.18mol hydroxyethyl methacrylate, 0.18mol triethanolamine and 210mL anhydrous tetrahydrofuran to the three-necked flask, stir well, add 100mL containing 0.18mol 2-chloro-2-oxo-1,3,2 - Tetrahydrofuran solution of dioxaphospholane, reflux reaction at -20°C for 4 hours to obtain intermediate 1, raise the temperature to 60°C, add 20.45g of 75% trimethylamine solution to intermediate 1, and reflux reaction 17h, intermediate 2 was obtained;

[0052] Step S2, add 3.95g of 2,2,5,5-tetramethyl-4-imidazolidinone into the flask, add 210mL of acetone, preheat the flask in an oil bath, wait for 2,2,5,5-tetra After methyl-4-imidazolidinone is dissolved, add 15.9g of potassium carbonate, reflux for 45min, add 21.8g of 1,3-dichloropropane, continue heating and reflux for 14h, distill off acetone under reduced pressure, add ethyl acetate, and then use deionized Washed 3 times with water to obtain Intermed...

Embodiment 3

[0058] The antibacterial coating is made by the following steps:

[0059] Step S1, add 0.22mol hydroxyethyl methacrylate, 0.22mol triethanolamine and 220mL anhydrous tetrahydrofuran to the three-necked flask, stir well, add 100mL containing 0.22mol 2-chloro-2-oxo-1,3,2 - Tetrahydrofuran solution of dioxaphospholane, reflux reaction at -20°C for 5 hours to obtain intermediate 1, raise the temperature to 60°C, add 20.45g of 80% trimethylamine solution to intermediate 1, and reflux reaction 20h, intermediate 2 was obtained;

[0060] Step S2, add 4.12g of 2,2,5,5-tetramethyl-4-imidazolidinone into the flask, add 220mL of acetone, preheat the flask in an oil bath, wait for 2,2,5,5-tetra After methyl-4-imidazolidinone is dissolved, add 16.2g of potassium carbonate, add 22.3g of 1,3-dichloropropane after reflux for 50min, continue heating and reflux for 16h, distill off acetone under reduced pressure, add ethyl acetate, and then use deionized Washed twice with water to obtain Inter...

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Abstract

The invention discloses a dental implant with hydrophilic and antibacterial properties, which comprises a titanium base material and an antibacterial coating, belongs to the technical field of dental implant materials, and aims to solve the problem that the hydrophilicity and antibacterial property of the dental implant still need to be improved. The preparation method comprises the following steps: ultrasonically cleaning a titanium substrate with acetone, absolute ethyl alcohol and deionized water in sequence, drying, carrying out anodic oxidation treatment and calcining, and coating the surface of the titanium substrate with an antibacterial coating to obtain the dental implant with hydrophilic and antibacterial properties. The antibacterial coating disclosed by the invention comprises a polymer and Ag-ZnO nanoparticles, the polymer is a polymer formed by copolymerizing phosphorylcholine lipids, polyacrylic acid, methoxy polyvinyl ether and trimethoxysilyl propyl methacrylate, and the phosphorylcholine lipids belong to zwitterionic lipids, so that the coating is endowed with biocompatibility and has bionic performance; the Ag-ZnO nano particles are more easily accepted by organisms, and the Ag-ZnO nano particles have excellent antibacterial performance.

Description

technical field [0001] The invention belongs to the technical field of dental implant materials, and relates to a dental implant with hydrophilic and antibacterial properties. Background technique [0002] Due to its good biocompatibility and excellent mechanical properties, titanium implants are more and more widely used in the field of dental and maxillofacial organ defect repair. Titanium-based biomaterials, mainly pure titanium or titanium alloys, have become the first choice for oral implants. Material. There are many factors that affect osseointegration, among which the surface properties of implants are particularly important, which has become the focus of research in recent years. Physical methods mainly refer to changes in the ultrastructure of the implant surface, including sandblasting and acid etching, electrolytic etching, laser treatment and surface treatment. ceramicization etc. The surface roughening technology of sandblasting and acid etching optimizes the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61C8/00A61C13/00
CPCA61C8/0013A61C13/0006A61C2008/0046
Inventor 崔竞铎王亚楠赵国蕾
Owner 山东恒泰医疗器械有限公司
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