Visual monodisperse embolism microsphere with internal radiotherapy performance and preparation method of visual monodisperse embolism microsphere

A technology for radiotherapy and embolization of microspheres, applied in the field of biomedicine, can solve the problems of invisible size, non-uniformity, non-degradability, etc., and achieve the effects of uniform shape, low production cost, and uniform and controllable size.

Active Publication Date: 2021-08-03
四川迈可隆生物科技有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

[0005] In view of the non-degradable, invisible and non-uniform size problems of the existing radioactive embolization microspheres, one of the purposes of the present invention is to provide a visualized monodisperse embolization microspheres with internal radiotherapy performance, so as to realize the embolization microspheres at the same time Degradable and visual...

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  • Visual monodisperse embolism microsphere with internal radiotherapy performance and preparation method of visual monodisperse embolism microsphere
  • Visual monodisperse embolism microsphere with internal radiotherapy performance and preparation method of visual monodisperse embolism microsphere
  • Visual monodisperse embolism microsphere with internal radiotherapy performance and preparation method of visual monodisperse embolism microsphere

Examples

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Embodiment 1

[0047] In this example, visualized monodisperse embolic microspheres with internal radiotherapy properties ( 131 1-poly GelMA microspheres), the steps are as follows:

[0048] (1) Preparation of internal phase, external phase fluid and collection solution

[0049] Prepare the internal phase fluid: Add the photoinitiator phenyl 2,4,6-trimethylbenzoyl lithium phosphonate (LAP) into deionized water, dissolve it in a water bath at 50°C to obtain a photoinitiator solution, add formazan Acrylylated gelatin (GelMA, double bond substitution degree is 90%) was added to the photoinitiator solution, dissolved uniformly in a water bath at 50°C, and filtered to obtain the internal phase fluid; in the internal phase fluid, deionized water, GelMA, LAP The mass ratio is 1:0.05:0.0025.

[0050] Prepare the external phase fluid: dissolving polyglycerin ricinoleate (PGPR) in soybean oil to obtain the external phase fluid; the mass ratio of soybean oil to PGPR in the external phase fluid is 1:0...

Embodiment 2

[0061] In this example, the preparation 131 I-poly GelMA microspheres, the steps are as follows:

[0062] (1) Preparation of internal phase, external phase fluid and collection solution

[0063] Prepare the internal phase fluid: add the photoinitiator LAP to deionized water, dissolve it uniformly in a water bath at 50°C to obtain a photoinitiator solution, add GelMA (the degree of substitution of the double bond is 90%) to the photoinitiator solution, and heat it at 50°C Dissolve evenly in a water bath, filter to obtain the internal phase fluid; the mass ratio of deionized water, GelMA, and LAP in the internal phase fluid is 1:0.05:0.0025.

[0064] Prepare the external phase fluid: dissolve PGPR in soybean oil to obtain the external phase fluid; the mass ratio of soybean oil to PGPR in the external phase fluid is 1:0.05.

[0065] Prepare the collection solution: the collection solution is the same as the external phase fluid.

[0066] (2) Preparation of monodisperse poly Ge...

Embodiment 3

[0075] In this example, the preparation 131 I-poly GelMA microspheres, the steps are as follows:

[0076] (1) Preparation of internal phase, external phase fluid and collection solution

[0077] Prepare the internal phase fluid: add the photoinitiator LAP to deionized water, dissolve it uniformly in a water bath at 50°C to obtain a photoinitiator solution, add GelMA (the degree of substitution of the double bond is 90%) to the photoinitiator solution, and heat it at 50°C Dissolve evenly in a water bath, filter to obtain the internal phase fluid; the mass ratio of deionized water, GelMA, and LAP in the internal phase fluid is 1:0.1:0.0025.

[0078] Prepare the external phase fluid: dissolve PGPR in soybean oil to obtain the external phase fluid; the mass ratio of soybean oil to PGPR in the external phase fluid is 1:0.05.

[0079] Prepare the collection solution: the collection solution is the same as the external phase fluid.

[0080] (2) Preparation of monodisperse poly Gel...

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Abstract

The invention provides a visual monodisperse embolism microsphere with internal radiation therapy performance, the embolism microsphere is composed of a polymer microsphere and radionuclide, the radionuclide is connected to the polymer microsphere through a chemical bond, and the base material of the polymer microsphere is a photo-initiated polymerization degradable polymer. The radionuclide is iodine-131, iodine-129, iodine-125, holmium-166, lutetium-177, rhenium-188 or indium-111. The particle size of the embolism microsphere is 20-100 [mu] m, and the variable coefficient of the particle size of the embolism microsphere does not exceed 5%. Degradability and visualization of the embolism microspheres in vivo are achieved at the same time, the monodispersity of the embolism microspheres is improved, the possibility of mistaken embolism can be reduced, and postoperative monitoring and evaluation are facilitated. The invention also provides a preparation method of the embolism microsphere. The method can simplify the preparation process, reduce the production cost and improve the production efficiency.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a visualized monodisperse embolic microsphere with internal radiotherapy performance and a preparation method thereof. Background technique [0002] When solid tumors develop into middle and advanced stages, they are often unresectable by surgery. Embolization therapy has become an alternative palliative treatment method. Embolization therapy injects embolic materials into blood vessels near the tumor through minimally invasive surgery, blocking the blood supply of the tumor, and embolization simultaneously. The material can also release chemotherapy drugs or irradiate radiation to kill surrounding tumor cells. Compared with ordinary chemotherapy or radiotherapy, embolization therapy can reduce side effects, improve patient compliance, and improve treatment efficiency. [0003] At present, most of the embolic materials used clinically are non-degradable, which is not conducive...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10A61L24/00A61K51/06A61K51/08A61K51/12A61K101/02A61K103/20A61K103/30
CPCA61L24/104A61L24/08A61L24/108A61L24/0042A61L24/001A61L24/0015A61K51/1251A61K51/08A61K51/06A61L2430/36
Inventor 巨晓洁蒋清蓉褚良银汪伟刘壮谢锐张文杰
Owner 四川迈可隆生物科技有限公司
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