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Preparation method of functional coating material for biological tissue scaffold or catheter

A technology of biological tissue and coating materials, applied in the direction of catheters, coatings, prostheses, etc., can solve the problems of obvious defects, poor effects, and long-term effects, etc., achieve simple operation process, reduce the probability of intimal hyperplasia, The effect of inhibiting the proliferation of smooth muscle cells

Active Publication Date: 2021-08-27
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But simply mixing the drug in the coating, the effect cannot last long, the defect is obvious, and the effect is still not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A method for preparing a functional coating material for a biological tissue scaffold, the specific steps are as follows:

[0036] (1) PEG-bis(4-nitrophenyl)carbonate (the number average molecular weight Mn of PEG is 800) and chitosan (the weight average molecular weight Mw is 50,000 with a mass ratio of 0.7:1, deacetylation degree 85%) react in the acetic acid solution whose concentration is 1.5% (v / v), then obtain PEG-grafted chitosan through freeze-drying and ethanol washing to remove impurities; wherein, the concentration of chitosan after being dissolved in acetic acid solution is 1.0wt%;

[0037] The degree of PEG grafting of the prepared PEG-grafted chitosan is 5%;

[0038] (2) After dissolving PEG-grafted chitosan in an acetic acid solution with a concentration of 20% (v / v), adding a NaOH solution with a concentration of 3mol / L to adjust the pH to 6, and then adding heparin sodium and FGF to obtain a mixed solution , stirred at 25°C for 1 hour to self-assemble...

Embodiment 2

[0056] A method for preparing a functional coating material for a biological tissue scaffold, the specific steps are as follows:

[0057] (1) PEG-bis(4-nitrophenyl)carbonate (the number-average molecular weight Mn of PEG is 1000) and chitosan (the weight-average molecular weight Mw is 80,000 with a mass ratio of 1:1, the degree of deacetylation 90%) react in the acetic acid solution whose concentration is 1.8% (v / v), then obtain PEG-grafted chitosan through freeze-drying and washing with ethanol to remove impurities; wherein, the concentration of chitosan after being dissolved in acetic acid solution is 2wt%;

[0058] The degree of PEG grafting of the prepared PEG-grafted chitosan is 7%;

[0059] (2) After dissolving the PEG-grafted chitosan in an acetic acid solution with a concentration of 20% (v / v), add a NaOH solution with a concentration of 3mol / L to adjust the pH to 6, and then add sodium tanshinone IIA sulfonate and VEGF Obtain the mixed solution, stir at 25 ℃ for 1.7...

Embodiment 3

[0064] A preparation method for a functional coating material for catheters, the specific steps are as follows:

[0065] (1) PEG-bis(4-nitrophenyl)carbonate (the number-average molecular weight Mn of PEG is 1500) and chitosan (the weight-average molecular weight Mw is 50,000 with a mass ratio of 1.4:1, deacetylation degree 90%) react in the acetic acid solution whose concentration is 1.9% (v / v), then obtain PEG-grafted chitosan through freeze-drying and ethanol washing to remove impurities; wherein, the concentration of chitosan after being dissolved in acetic acid solution is 2.3 wt%;

[0066] The degree of PEG grafting of the prepared PEG-grafted chitosan is 10%;

[0067] (2) After dissolving the PEG-grafted chitosan in the acetic acid solution with a concentration of 20% (v / v), adding a NaOH solution with a concentration of 3mol / L to adjust the pH to 6, and then adding sodium tanshinone IIA sulfonate to obtain a mixture Solution, stirred at 25 ℃ for 1.8 hours to self-asse...

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Abstract

The invention relates to a preparation method of a functional coating material for biological tissue scaffolds or catheters, which comprises the following steps of: self-assembling PEG (polyethylene glycol) grafted chitosan and one or more of a functional compound and a growth factor in a solution state to obtain a functional composite material solution; and coating a substrate and then carrying out crosslinking treatment to obtain a functional coating material, wherein the substrate is a biological tissue scaffold or catheter, and the functional compound is a compound with a sulfonic acid group. The functional coating material prepared by the preparation method can regulate and control the antithrombotic performance of an intravascular stent, and meanwhile, functional compounds / growth factors and the like can also induce stem cells and endothelial cells / progenitor cells in blood to gather on the material, so that endothelialization is accelerated.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a preparation method of a functional coating material used for biological tissue brackets or catheters. Background technique [0002] At present, vascular grafting is widely used in the treatment of cardiovascular diseases, including coronary artery bypass grafting, hemodialysis, and diabetic lower extremity vascular disease. At present, large-diameter (diameter ≥ 6mm) artificial blood vessels made of polyethylene phthalate (PET), expanded polytetrafluoroethylene (ePTFE) and other materials have been widely used in the treatment of aortic diseases. However, small-diameter blood vessels (caliber <6mm) are in a special state of high tension and low blood flow, and the use of small-diameter artificial blood vessels made of the above two materials (referred to as: vascular stents) has a high failure rate after transplantation, mainly It is characterized by thrombosis a...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/48A61L27/22A61L27/54A61L29/04A61L29/12A61L29/08C08B37/08
CPCA61L27/34A61L27/54A61L27/227A61L27/48A61L29/085A61L29/126A61L29/048C08B37/003A61L2300/414A61L2300/42A61L2300/606C08L5/08
Inventor 尹岸林樊勇勇李雲环颜志勇詹建朝许志
Owner JIAXING UNIV
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