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Intestinal tract fecal microbe microcapsule and preparation method thereof

A technology of microcapsules and fecal bacteria, applied in the directions of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of inconvenience of use and short storage time at room temperature, and achieve the effects of convenient administration, long storage time and good tolerance.

Pending Publication Date: 2021-09-07
成都仕康美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the modern fecal and bacterial transplantation technology is mainly a method of instrument intervention, and the patient has a certain degree of pain.
In addition, fecal bacteria cannot be stored at room temperature for a short period of time. For long-term storage, sterile glycerin must be added and then frozen at -80°C, which is inconvenient to use.

Method used

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  • Intestinal tract fecal microbe microcapsule and preparation method thereof
  • Intestinal tract fecal microbe microcapsule and preparation method thereof
  • Intestinal tract fecal microbe microcapsule and preparation method thereof

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preparation example Construction

[0047] The present invention also discloses a preparation method of the above intestinal fecal microcapsules, comprising the following steps:

[0048] Preparation of S1 Fecal Bacteria Precipitate

[0049] S11 Collect stool samples from healthy people and add them to sterile saline;

[0050] S12 Use a magnetic stirrer to stir the sample evenly until there are no obvious large particles to make a feces suspension;

[0051] S13 filter the feces suspension once using sieves with different pore sizes, and collect the filtrate;

[0052] S14 filters the filtrate collected in the previous step with a filter membrane once, and collects the filtrate;

[0053] S15 Centrifuge the filtrate collected in the previous step, remove the supernatant, and obtain the fecal bacteria precipitate;

[0054] Preparation of S2 inner embedding layer

[0055]Preparation of S21 embedding agent: 1-10 parts of glycerin, 5-15 parts of lactose, 5-20 parts of skimmed milk powder, 1-5 parts of sodium glutama...

Embodiment 1

[0070] The intestinal fecal microcapsules of this embodiment have an inner embedding layer and an outer embedding layer, and the inner embedding layer includes an embedding agent and fecal bacteria sediment; the embedding agent includes: 1 part of glycerin in parts by mass , 5 parts of lactose, 5 parts of skim milk powder, 1 part of sodium glutamate, 1 part of vitamin E, 1 part of sucrose fatty acid ester, 1 part of fructooligosaccharide, 1 part of mannitol, 1 part of peptone, 1 part of yeast extract, 1 part of glutathione; the mass ratio of fecal bacteria sediment to embedding agent is 10:90;

[0071] The outer embedding layer comprises, in parts by mass: 0.5 part of polyoxyethylene xylitol anhydride monostearate, 1 part of sodium alginate, 1 part of edible gelatin, and 0.5 part of polyamide.

[0072] The preparation method of the above-mentioned intestinal fecal bacteria microcapsules comprises the following steps:

[0073] Preparation of S1 Fecal Bacteria Precipitate

[0...

Embodiment 2

[0086] The intestinal fecal bacteria microcapsules of this embodiment have an inner embedding layer and an outer embedding layer, and the inner embedding layer includes embedding agent and fecal bacteria sediment; the embedding agent includes by mass parts: 10 parts of glycerin , 15 parts of lactose, 20 parts of skimmed milk powder, 5 parts of sodium glutamate, 5 parts of vitamin E, 10 parts of sucrose fatty acid ester, 10 parts of fructooligosaccharide, 10 parts of mannitol, 5 parts of peptone, 5 parts of yeast extract, 5 parts of glutathione; the mass ratio of fecal bacteria sediment to embedding agent is 1:99;

[0087] The outer embedding layer comprises, in parts by mass: 2 parts of polyoxyethylene xylitol anhydride monostearate, 5 parts of sodium alginate, 3 parts of edible gelatin, and 1 part of polyamide.

[0088] The preparation method of the above-mentioned intestinal fecal bacteria microcapsules comprises the following steps:

[0089] Preparation of S1 Fecal Bacteri...

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Abstract

The invention discloses an intestinal tract fecal microbe microcapsule and a preparation method thereof. The intestinal tract fecal microbe microcapsule comprises an inner embedding layer and an outer embedding layer, and the inner embedding layer comprises an embedding medium and fecal microbe sediment; the embedding medium is prepared from the following components in parts by mass: 1-10 parts of glycerol, 5-15 parts of lactose, 5-20 parts of skim milk powder, 1-5 parts of sodium glutamate, 1-5 parts of vitamin E, 1-10 parts of sucrose fatty acid ester, 1-10 parts of fructo-oligosaccharide, 1-10 parts of mannitol, 1-5 parts of peptone, 1-5 parts of a yeast extract and 1-5 parts of glutathione; and the mass ratio of the fecal microbe sediment to the embedding medium is (1-10): (90-99).The intestinal tract fecal microbe microcapsule has good tolerance to gastric acid, cholate and various digestive enzymes in the digestive tract, and is long in preservation time, convenient to take and suitable for being taken by various patients.

Description

technical field [0001] The invention relates to the field of fecal bacteria transplantation, in particular to an intestinal fecal bacteria microcapsule and a preparation method thereof. Background technique [0002] Fecal microbiota transplantation therapy refers to the transplantation of functional flora in the feces of healthy people into the intestinal tract of patients with functional constipation, helping patients to re-establish the normal balance of intestinal flora, which can effectively treat or improve a variety of intestinal-related diseases. clinical disease. Fecal microbiota transplantation is a generalized probiotic treatment method, which can rebuild the intestinal functional flora of patients with constipation, and transplant the intestinal flora of healthy people into the intestinal tract of patients, so as to make the dominant bacteria multiply and reduce the risk of disease. The number of bacteria accounted for, thereby improving the flora of the gastroin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K9/50A61K47/10A61K47/42A61K47/36A61P1/10
CPCA61K35/74A61K9/5015A61K9/5036A61K9/5052A61P1/10
Inventor 魏亮
Owner 成都仕康美生物科技有限公司
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